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Index > Protein center > Tlr4(Gene name) > Mouse
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  • Tlr4 (Gene name),
  • Toll-like receptor 4 (Protein name ),  TLR4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Tlr4(Lps);
    Protein name:
    Toll-like receptor 4;
    Alternative:

    CD:
    CD284;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
    Function:
    Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    835
    Sequence:
    50:
    MMPPWLLART | LIMALFFSCL | TPGSLNPCIE | VVPNITYQCM | DQKLSKVPDD | 
    100:
    IPSSTKNIDL | SFNPLKILKS | YSFSNFSELQ | WLDLSRCEIE | TIEDKAWHGL | 
    150:
    HHLSNLILTG | NPIQSFSPGS | FSGLTSLENL | VAVETKLASL | ESFPIGQLIT | 
    200:
    LKKLNVAHNF | IHSCKLPAYF | SNLTNLVHVD | LSYNYIQTIT | VNDLQFLREN | 
    250:
    PQVNLSLDMS | LNPIDFIQDQ | AFQGIKLHEL | TLRGNFNSSN | IMKTCLQNLA | 
    300:
    GLHVHRLILG | EFKDERNLEI | FEPSIMEGLC | DVTIDEFRLT | YTNDFSDDIV | 
    350:
    KFHCLANVSA | MSLAGVSIKY | LEDVPKHFKW | QSLSIIRCQL | KQFPTLDLPF | 
    400:
    LKSLTLTMNK | GSISFKKVAL | PSLSYLDLSR | NALSFSGCCS | YSDLGTNSLR | 
    450:
    HLDLSFNGAI | IMSANFMGLE | ELQHLDFQHS | TLKRVTEFSA | FLSLEKLLYL | 
    500:
    DISYTNTKID | FDGIFLGLTS | LNTLKMAGNS | FKDNTLSNVF | ANTTNLTFLD | 
    550:
    LSKCQLEQIS | WGVFDTLHRL | QLLNMSHNNL | LFLDSSHYNQ | LYSLSTLDCS | 
    600:
    FNRIETSKGI | LQHFPKSLAF | FNLTNNSVAC | ICEHQKFLQW | VKEQKQFLVN | 
    650:
    VEQMTCATPV | EMNTSLVLDF | NNSTCYMYKT | IISVSVVSVI | VVSTVAFLIY | 
    700:
    HFYFHLILIA | GCKKYSRGES | IYDAFVIYSS | QNEDWVRNEL | VKNLEEGVPR | 
    750:
    FHLCLHYRDF | IPGVAIAANI | IQEGFHKSRK | VIVVVSRHFI | QSRWCIFEYE | 
    800:
    IAQTWQFLSS | RSGIIFIVLE | KVEKSLLRQQ | VELYRLLSRN | TYLEWEDNPL | 
    835:
    GRHIFWRRLK | NALLDGKASN | PEQTAEEEQE | TATWT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    SMR:
    KEGG:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Toll-like receptor 4
    Cat.:
    E0753h
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    Packing:
    96T
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    ELISA Kit for Mouse Toll-like receptor 4
    Cat.:
    E0753m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Toll-like receptor 4
    Cat.:
    E0753r
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    96T
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    ELISA Kit for Mouse Toll-like receptor 4
    Cat.:
    E0753p
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    96T
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    ELISA Kit for Mouse Toll-like receptor 4
    Cat.:
    E0753b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Toll-like receptor 4
    Cat.:
    U0753b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Toll-like receptor 4
    Cat.:
    U0753h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Toll-like receptor 4
    Cat.:
    U0753p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Toll-like receptor 4
    Cat.:
    U0753r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse Toll-like receptor 4
    Cat.:
    U0753m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Mouse Toll-like receptor 4
    Cat.:
    P0753Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Toll-like receptor 4
    Polyclonal Antibody for Mouse Toll-like receptor 4
    Cat.:
    P0753Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Toll-like receptor 4
    Polyclonal Antibody for Mouse Toll-like receptor 4
    Cat.:
    P0753Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Toll-like receptor 4
    Monoclonal Antibody for Mouse Toll-like receptor 4
    Monoclonal Antibody for Mouse Toll-like receptor 4
    Monoclonal Antibody for Mouse Toll-like receptor 4
    Cat.:
    M0753h
    Price:
    Please sign in first.
    Packing:
    40ug
    Monoclonal Antibody for Mouse Toll-like receptor 4
    Protein for Mouse Toll-like receptor 4
    Protein for Mouse Toll-like receptor 4
    Cat.:
    R0753h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse Toll-like receptor 4
    Protein for Mouse Toll-like receptor 4
    Protein for Mouse Toll-like receptor 4

    R&D Technical Data

    12% SDS-PAGE analysis

    12% SDS-PAGE analysis

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    Precision
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    Linearity
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    References
    1. 1.
      "Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region."
      Poltorak A. , Smirnova I. , He X. , Liu M.-Y. , Van Huffel C. , Birdwell D. , Alejos E. , Silva M. , Du X. , Thompson P. , Chan E.K.L. , Ledesma J. , Roe B. , Clifton S. , Vogel S.N. , Beutler B.
      Blood Cells Mol. Dis.24:340-355(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: C3H/HeJ.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LPS-TOLERANT HIS-712
      strain: C3H/HeJ.
    3. 3.
      "Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)."
      Qureshi S.T. , Lariviere L. , Leveque G. , Clermont S. , Moore K.J. , Gros P. , Malo D.
      J. Exp. Med.189:615-625(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LPS-TOLERANT HIS-712
      strain: C57BL/6J.
    4. 4.
      "The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens."
      Underhill D.M. , Ozinsky A. , Hajjar A.M. , Stevens A. , Wilson C.B. , Bassetti M. , Aderem A.
      Nature401:811-815(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Macrophage.
    5. 5.
      "Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)."
      Smirnova I. , Poltorak A. , Chan E.K.L. , McBride C. , Beutler B.
      Genome Biol.1:RESEARCH002.1-RESEARCH002.10(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-94; ILE-209; GLY-219; ILE-254; LEU-423; SER-477; ALA-516; ASP-593; ILE-600; VAL-607; ILE-637; HIS-761 AND LYS-811
      strain: Various strains.
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-154
      strain: C57BL/6J.
      tissue: Skin.
    7. 7.
      "Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase."
      Rhee S.H. , Hwang D.
      J. Biol. Chem.275:34035-34040(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity."
      Kim F. , Pham M. , Luttrell I. , Bannerman D.D. , Tupper J. , Thaler J. , Hawn T.R. , Raines E.W. , Schwartz M.W.
      Circ. Res.100:1589-1596(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors."
      Kiyokawa T. , Akashi-Takamura S. , Shibata T. , Matsumoto F. , Nishitani C. , Kuroki Y. , Seto Y. , Miyake K.
      Int. Immunol.20:1407-1415(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNPY3
    10. 10.
      "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
      Liu B. , Yang Y. , Qiu Z. , Staron M. , Hong F. , Li Y. , Wu S. , Li Y. , Hao B. , Bona R. , Han D. , Li Z.
      Nat. Commun.1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSP90B1
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    12. 12.
      "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
      Stewart C.R. , Stuart L.M. , Wilkinson K. , van Gils J.M. , Deng J. , Halle A. , Rayner K.J. , Boyer L. , Zhong R. , Frazier W.A. , Lacy-Hulbert A. , El Khoury J. , Golenbock D.T. , Moore K.J.
      Nat. Immunol.11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."
      Kim H.M. , Park B.S. , Kim J.-I. , Kim S.E. , Lee J. , Oh S.C. , Enkhbayar P. , Matsushima N. , Lee H. , Yoo O.J. , Lee J.-O.
      Cell130:906-917(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.84 ANGSTROMS) OF 27-625 IN COMPLEX WITH LY96;GLYCOSYLATION AT ASN-34; ASN-75; ASN-172; ASN-204; ASN-237; ASN-307; ASN-492; ASN-524 AND ASN-572
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