Protein name:
Toll-like receptor 4 ;
Alternative:
CD:
CD284 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
Function:
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MMPPWLLART | LIMALFFSCL | TPGSLNPCIE | VVPNITYQCM | DQKLSKVPDD |
100:
IPSSTKNIDL | SFNPLKILKS | YSFSNFSELQ | WLDLSRCEIE | TIEDKAWHGL |
150:
HHLSNLILTG | NPIQSFSPGS | FSGLTSLENL | VAVETKLASL | ESFPIGQLIT |
200:
LKKLNVAHNF | IHSCKLPAYF | SNLTNLVHVD | LSYNYIQTIT | VNDLQFLREN |
250:
PQVNLSLDMS | LNPIDFIQDQ | AFQGIKLHEL | TLRGNFNSSN | IMKTCLQNLA |
300:
GLHVHRLILG | EFKDERNLEI | FEPSIMEGLC | DVTIDEFRLT | YTNDFSDDIV |
350:
KFHCLANVSA | MSLAGVSIKY | LEDVPKHFKW | QSLSIIRCQL | KQFPTLDLPF |
400:
LKSLTLTMNK | GSISFKKVAL | PSLSYLDLSR | NALSFSGCCS | YSDLGTNSLR |
450:
HLDLSFNGAI | IMSANFMGLE | ELQHLDFQHS | TLKRVTEFSA | FLSLEKLLYL |
500:
DISYTNTKID | FDGIFLGLTS | LNTLKMAGNS | FKDNTLSNVF | ANTTNLTFLD |
550:
LSKCQLEQIS | WGVFDTLHRL | QLLNMSHNNL | LFLDSSHYNQ | LYSLSTLDCS |
600:
FNRIETSKGI | LQHFPKSLAF | FNLTNNSVAC | ICEHQKFLQW | VKEQKQFLVN |
650:
VEQMTCATPV | EMNTSLVLDF | NNSTCYMYKT | IISVSVVSVI | VVSTVAFLIY |
700:
HFYFHLILIA | GCKKYSRGES | IYDAFVIYSS | QNEDWVRNEL | VKNLEEGVPR |
750:
FHLCLHYRDF | IPGVAIAANI | IQEGFHKSRK | VIVVVSRHFI | QSRWCIFEYE |
800:
IAQTWQFLSS | RSGIIFIVLE | KVEKSLLRQQ | VELYRLLSRN | TYLEWEDNPL |
835:
GRHIFWRRLK | NALLDGKASN | PEQTAEEEQE | TATWT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
ELISA Kit for Mouse Toll-like receptor 4
ELISA Kit for Mouse Toll-like receptor 4
ELISA Kit for Mouse Toll-like receptor 4
ELISA Kit for Mouse Toll-like receptor 4
ELISA Kit for Mouse Toll-like receptor 4
CLIA Kit for Mouse Toll-like receptor 4
CLIA Kit for Mouse Toll-like receptor 4
CLIA Kit for Mouse Toll-like receptor 4
CLIA Kit for Mouse Toll-like receptor 4
CLIA Kit for Mouse Toll-like receptor 4
Polyclonal Antibody for Mouse Toll-like receptor 4
Polyclonal Antibody for Mouse Toll-like receptor 4
Polyclonal Antibody for Mouse Toll-like receptor 4
Polyclonal Antibody for Mouse Toll-like receptor 4
Polyclonal Antibody for Mouse Toll-like receptor 4
Monoclonal Antibody for Mouse Toll-like receptor 4
Monoclonal Antibody for Mouse Toll-like receptor 4
Monoclonal Antibody for Mouse Toll-like receptor 4
Monoclonal Antibody for Mouse Toll-like receptor 4
Monoclonal Antibody for Mouse Toll-like receptor 4
Protein for Mouse Toll-like receptor 4
Protein for Mouse Toll-like receptor 4
Protein for Mouse Toll-like receptor 4
Protein for Mouse Toll-like receptor 4
Protein for Mouse Toll-like receptor 4
R&D Technical Data
12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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References
1.
"Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region."
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
C3H/HeJ .
2.
"Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene."
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Science282:2085-2088(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT LPS-TOLERANT HIS-712
strain :
C3H/HeJ .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT LPS-TOLERANT HIS-712
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Macrophage .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-94; ILE-209; GLY-219; ILE-254; LEU-423; SER-477; ALA-516; ASP-593; ILE-600; VAL-607; ILE-637; HIS-761 AND LYS-811
strain :
Various strains .
6.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-154
strain :
C57BL/6J .
tissue :
Skin .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CNPY3
10.
"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B.
,
Yang Y.
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Qiu Z.
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Li Z.
Nat. Commun.1:79-79(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HSP90B1
11.
Liu B.
,
Yang Y.
,
Qiu Z.
,
Staron M.
,
Hong F.
,
Li Y.
,
Wu S.
,
Li Y.
,
Hao B.
,
Bona R.
,
Han D.
,
Li Z.
Nat. Commun.3:653-653(2012)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
12.
"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Stewart C.R.
,
Stuart L.M.
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Deng J.
,
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Nat. Immunol.11:155-161(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."
Kim H.M.
,
Park B.S.
,
Kim J.-I.
,
Kim S.E.
,
Lee J.
,
Oh S.C.
,
Enkhbayar P.
,
Matsushima N.
,
Lee H.
,
Yoo O.J.
,
Lee J.-O.
Cell130:906-917(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.84 ANGSTROMS) OF 27-625 IN COMPLEX WITH LY96;GLYCOSYLATION AT ASN-34; ASN-75; ASN-172; ASN-204; ASN-237; ASN-307; ASN-492; ASN-524 AND ASN-572