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Index > Protein center > Tlr4(Gene name) > Rat
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  • Tlr4 (Gene name),
  • Toll-like receptor 4 (Protein name ),  TLR4_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Tlr4;
    Protein name:
    Toll-like receptor 4(Toll4);
    Alternative:

    CD:
    CD284;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
    Function:
    Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    835
    Sequence:
    50:
    MMPLLHLAGT | LIMALFLSCL | RPGSLNPCIE | VLPNITYQCM | DQNLSKIPHD | 
    100:
    IPYSTKNLDL | SFNPLKILRS | YSFTNFSQLQ | WLDLSRCEIE | TIEDKAWHGL | 
    150:
    NQLSTLVLTG | NPIKSFSPGS | FSGLTNLENL | VAVETKMTSL | EGFHIGQLIS | 
    200:
    LKKLNVAHNL | IHSFKLPEYF | SNLTNLEHVD | LSYNYIQTIS | VKDLQFLREN | 
    250:
    PQVNLSLDLS | LNPIDSIQAQ | AFQGIRLHEL | TLRSNFNSSN | VLKMCLQNMT | 
    300:
    GLHVHRLILG | EFKNERNLES | FDRSVMEGLC | NVSIDEFRLT | YINHFSDDIY | 
    350:
    NLNCLANISA | MSFTGVHIKH | IADVPRHFKW | QSLSIIRCHL | KPFPKLSLPF | 
    400:
    LKSWTLTTNR | EDISFGQLAL | PSLRYLDLSR | NAMSFRGCCS | YSDFGTNNLK | 
    450:
    YLDLSFNGVI | LMSANFMGLE | ELEYLDFQHS | TLKKVTEFSV | FLSLEKLLYL | 
    500:
    DISYTNTKID | FDGIFLGLIS | LNTLKMAGNS | FKDNTLSNVF | TNTTNLTFLD | 
    550:
    LSKCQLEQIS | RGVFDTLYRL | QLLNMSHNNL | LFLDPSHYKQ | LYSLRTLDCS | 
    600:
    FNRIETSKGI | LQHFPKSLAV | FNLTNNSVAC | ICEYQNFLQW | VKDQKMFLVN | 
    650:
    VEQMKCASPI | DMKASLVLDF | TNSTCYIYKT | IISVSVVSVL | VVATVAFLIY | 
    700:
    HFYFHLILIA | GCKKYSRGES | IYDAFVIYSS | QNEDWVRNEL | VKNLEEGVPR | 
    750:
    FQLCLHYRDF | IPGVAIAANI | IQEGFHKSRK | VIVVVSRHFI | QSRWCIFEYE | 
    800:
    IAQTWQFLSS | RSGIIFIVLE | KVEKSLLRQQ | VELYRLLSRN | TYLEWEDNAL | 
    835:
    GRHIFWRRLK | KALLDGKALN | PDETSEEEQE | ATTLT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    KEGG:
    SMR:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Toll4
    Cat.:
    E0753h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Toll4
    Cat.:
    E0753m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Toll4
    Cat.:
    E0753r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Toll4
    Cat.:
    E0753p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Toll4
    Cat.:
    E0753b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Toll4
    Cat.:
    U0753b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Toll4
    Cat.:
    U0753h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Toll4
    Cat.:
    U0753p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Toll4
    Cat.:
    U0753r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Toll4
    Cat.:
    U0753m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Toll4
    Cat.:
    P0753Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Toll4
    Polyclonal Antibody for Rat Toll4
    Cat.:
    P0753Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Toll4
    Polyclonal Antibody for Rat Toll4
    Cat.:
    P0753Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Toll4
    Monoclonal Antibody for Rat Toll4
    Monoclonal Antibody for Rat Toll4
    Monoclonal Antibody for Rat Toll4
    Cat.:
    M0753h
    Price:
    Please sign in first.
    Packing:
    40ug
    Monoclonal Antibody for Rat Toll4
    Protein for Rat Toll4
    Protein for Rat Toll4
    Cat.:
    R0753h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat Toll4
    Protein for Rat Toll4
    Protein for Rat Toll4

    R&D Technical Data

    12% SDS-PAGE analysis

    12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium."
      Frantz S. , Kobzik L. , Kim Y.-D. , Fukazawa R. , Medzhitov R. , Lee R.T. , Kelly R.A.
      J. Clin. Invest.104:271-280(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Heart.
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