Protein name:
Toll-like receptor 4 (Toll4) ;
Alternative:
CD:
CD284 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
Function:
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MMPLLHLAGT | LIMALFLSCL | RPGSLNPCIE | VLPNITYQCM | DQNLSKIPHD |
100:
IPYSTKNLDL | SFNPLKILRS | YSFTNFSQLQ | WLDLSRCEIE | TIEDKAWHGL |
150:
NQLSTLVLTG | NPIKSFSPGS | FSGLTNLENL | VAVETKMTSL | EGFHIGQLIS |
200:
LKKLNVAHNL | IHSFKLPEYF | SNLTNLEHVD | LSYNYIQTIS | VKDLQFLREN |
250:
PQVNLSLDLS | LNPIDSIQAQ | AFQGIRLHEL | TLRSNFNSSN | VLKMCLQNMT |
300:
GLHVHRLILG | EFKNERNLES | FDRSVMEGLC | NVSIDEFRLT | YINHFSDDIY |
350:
NLNCLANISA | MSFTGVHIKH | IADVPRHFKW | QSLSIIRCHL | KPFPKLSLPF |
400:
LKSWTLTTNR | EDISFGQLAL | PSLRYLDLSR | NAMSFRGCCS | YSDFGTNNLK |
450:
YLDLSFNGVI | LMSANFMGLE | ELEYLDFQHS | TLKKVTEFSV | FLSLEKLLYL |
500:
DISYTNTKID | FDGIFLGLIS | LNTLKMAGNS | FKDNTLSNVF | TNTTNLTFLD |
550:
LSKCQLEQIS | RGVFDTLYRL | QLLNMSHNNL | LFLDPSHYKQ | LYSLRTLDCS |
600:
FNRIETSKGI | LQHFPKSLAV | FNLTNNSVAC | ICEYQNFLQW | VKDQKMFLVN |
650:
VEQMKCASPI | DMKASLVLDF | TNSTCYIYKT | IISVSVVSVL | VVATVAFLIY |
700:
HFYFHLILIA | GCKKYSRGES | IYDAFVIYSS | QNEDWVRNEL | VKNLEEGVPR |
750:
FQLCLHYRDF | IPGVAIAANI | IQEGFHKSRK | VIVVVSRHFI | QSRWCIFEYE |
800:
IAQTWQFLSS | RSGIIFIVLE | KVEKSLLRQQ | VELYRLLSRN | TYLEWEDNAL |
835:
GRHIFWRRLK | KALLDGKALN | PDETSEEEQE | ATTLT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Polyclonal Antibody for Rat Toll4
Polyclonal Antibody for Rat Toll4
Polyclonal Antibody for Rat Toll4
Polyclonal Antibody for Rat Toll4
Polyclonal Antibody for Rat Toll4
Monoclonal Antibody for Rat Toll4
Monoclonal Antibody for Rat Toll4
Monoclonal Antibody for Rat Toll4
Monoclonal Antibody for Rat Toll4
Monoclonal Antibody for Rat Toll4
R&D Technical Data
12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Heart .