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Index > Protein center > TLR7(Gene name) > Human
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  • TLR7 (Gene name),
  • Toll-like receptor 7 (Protein name ),  TLR7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TLR7(UNQ248/PRO285);
    Protein name:
    Toll-like receptor 7;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.
    Function:
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle phagosome Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
    Protein Attributes:
    Sequence length:
    1049
    Sequence:
    50:
    MVFPMWTLKR | QILILFNIIL | ISKLLGARWF | PKTLPCDVTL | DVPKNHVIVD | 
    100:
    CTDKHLTEIP | GGIPTNTTNL | TLTINHIPDI | SPASFHRLDH | LVEIDFRCNC | 
    150:
    VPIPLGSKNN | MCIKRLQIKP | RSFSGLTYLK | SLYLDGNQLL | EIPQGLPPSL | 
    200:
    QLLSLEANNI | FSIRKENLTE | LANIEILYLG | QNCYYRNPCY | VSYSIEKDAF | 
    250:
    LNLTKLKVLS | LKDNNVTAVP | TVLPSTLTEL | YLYNNMIAKI | QEDDFNNLNQ | 
    300:
    LQILDLSGNC | PRCYNAPFPC | APCKNNSPLQ | IPVNAFDALT | ELKVLRLHSN | 
    350:
    SLQHVPPRWF | KNINKLQELD | LSQNFLAKEI | GDAKFLHFLP | SLIQLDLSFN | 
    400:
    FELQVYRASM | NLSQAFSSLK | SLKILRIRGY | VFKELKSFNL | SPLHNLQNLE | 
    450:
    VLDLGTNFIK | IANLSMFKQF | KRLKVIDLSV | NKISPSGDSS | EVGFCSNART | 
    500:
    SVESYEPQVL | EQLHYFRYDK | YARSCRFKNK | EASFMSVNES | CYKYGQTLDL | 
    550:
    SKNSIFFVKS | SDFQHLSFLK | CLNLSGNLIS | QTLNGSEFQP | LAELRYLDFS | 
    600:
    NNRLDLLHST | AFEELHKLEV | LDISSNSHYF | QSEGITHMLN | FTKNLKVLQK | 
    650:
    LMMNDNDISS | STSRTMESES | LRTLEFRGNH | LDVLWREGDN | RYLQLFKNLL | 
    700:
    KLEELDISKN | SLSFLPSGVF | DGMPPNLKNL | SLAKNGLKSF | SWKKLQCLKN | 
    750:
    LETLDLSHNQ | LTTVPERLSN | CSRSLKNLIL | KNNQIRSLTK | YFLQDAFQLR | 
    800:
    YLDLSSNKIQ | MIQKTSFPEN | VLNNLKMLLL | HHNRFLCTCD | AVWFVWWVNH | 
    850:
    TEVTIPYLAT | DVTCVGPGAH | KGQSVISLDL | YTCELDLTNL | ILFSLSISVS | 
    900:
    LFLMVMMTAS | HLYFWDVWYI | YHFCKAKIKG | YQRLISPDCC | YDAFIVYDTK | 
    950:
    DPAVTEWVLA | ELVAKLEDPR | EKHFNLCLEE | RDWLPGQPVL | ENLSQSIQLS | 
    1000:
    KKTVFVMTDK | YAKTENFKIA | FYLSHQRLMD | EKVDVIILIF | LEKPFQKSKF | 
    1049:
    LQLRKRLCGS | SVLEWPTNPQ | AHPYFWQCLK | NALATDNHVA | YSQVFKETV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Toll-like receptor 7
    Cat.:
    E1950h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Toll-like receptor 7
    Cat.:
    E1950m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Toll-like receptor 7
    Cat.:
    U1950h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Toll-like receptor 7
    Cat.:
    U1950m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Toll-like receptor 7
    Cat.:
    P1950Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Toll-like receptor 7
    Cat.:
    P1950Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Toll-like receptor 7
    Monoclonal Antibody for Human Toll-like receptor 7
    Protein for Human Toll-like receptor 7
    Protein for Human Toll-like receptor 7

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
      Du X. , Poltorak A. , Wei Y. , Beutler B.
      Eur. Cytokine Netw.11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    2. 2.
      "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
      Chuang T.-H. , Ulevitch R.J.
      Eur. Cytokine Netw.11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    3. 3.
      "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P. , Macquin C. , Bahram S.
      PLoS ONE4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-11
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    6. 6.
      "TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages."
      Gantier M.P. , Tong S. , Behlke M.A. , Xu D. , Phipps S. , Foster P.S. , Williams B.R.
      J. Immunol.180:2117-2124(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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