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Index > Protein center > TLR8(Gene name) > Human
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  • TLR8 (Gene name),
  • Toll-like receptor 8 (Protein name ),  TLR8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    TLR8(UNQ249/PRO286);
    Protein name:
    Toll-like receptor 8;
    Alternative:

    CD:
    CD288;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Interacts with BTK.
    Function:
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1041
    Sequence:
    50:
    MENMFLQSSM | LTCIFLLISG | SCELCAEENF | SRSYPCDEKK | QNDSVIAECS | 
    100:
    NRRLQEVPQT | VGKYVTELDL | SDNFITHITN | ESFQGLQNLT | KINLNHNPNV | 
    150:
    QHQNGNPGIQ | SNGLNITDGA | FLNLKNLREL | LLEDNQLPQI | PSGLPESLTE | 
    200:
    LSLIQNNIYN | ITKEGISRLI | NLKNLYLAWN | CYFNKVCEKT | NIEDGVFETL | 
    250:
    TNLELLSLSF | NSLSHVPPKL | PSSLRKLFLS | NTQIKYISEE | DFKGLINLTL | 
    300:
    LDLSGNCPRC | FNAPFPCVPC | DGGASINIDR | FAFQNLTQLR | YLNLSSTSLR | 
    350:
    KINAAWFKNM | PHLKVLDLEF | NYLVGEIASG | AFLTMLPRLE | ILDLSFNYIK | 
    400:
    GSYPQHINIS | RNFSKLLSLR | ALHLRGYVFQ | ELREDDFQPL | MQLPNLSTIN | 
    450:
    LGINFIKQID | FKLFQNFSNL | EIIYLSENRI | SPLVKDTRQS | YANSSSFQRH | 
    500:
    IRKRRSTDFE | FDPHSNFYHF | TRPLIKPQCA | AYGKALDLSL | NSIFFIGPNQ | 
    550:
    FENLPDIACL | NLSANSNAQV | LSGTEFSAIP | HVKYLDLTNN | RLDFDNASAL | 
    600:
    TELSDLEVLD | LSYNSHYFRI | AGVTHHLEFI | QNFTNLKVLN | LSHNNIYTLT | 
    650:
    DKYNLESKSL | VELVFSGNRL | DILWNDDDNR | YISIFKGLKN | LTRLDLSLNR | 
    700:
    LKHIPNEAFL | NLPASLTELH | INDNMLKFFN | WTLLQQFPRL | ELLDLRGNKL | 
    750:
    LFLTDSLSDF | TSSLRTLLLS | HNRISHLPSG | FLSEVSSLKH | LDLSSNLLKT | 
    800:
    INKSALETKT | TTKLSMLELH | GNPFECTCDI | GDFRRWMDEH | LNVKIPRLVD | 
    850:
    VICASPGDQR | GKSIVSLELT | TCVSDVTAVI | LFFFTFFITT | MVMLAALAHH | 
    900:
    LFYWDVWFIY | NVCLAKVKGY | RSLSTSQTFY | DAYISYDTKD | ASVTDWVINE | 
    950:
    LRYHLEESRD | KNVLLCLEER | DWDPGLAIID | NLMQSINQSK | KTVFVLTKKY | 
    1000:
    AKSWNFKTAF | YLALQRLMDE | NMDVIIFILL | EPVLQHSQYL | RLRQRICKSS | 
    1041:
    ILQWPDNPKA | EGLFWQTLRN | VVLTENDSRY | NNMYVDSIKQ | Y
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    KEGG:
    MIM:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
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    MSDS:
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Human Toll-like receptor 8
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    Packing:
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    Polyclonal Antibody for Human Toll-like receptor 8
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    Packing:
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    Monoclonal Antibody for Human Toll-like receptor 8
    Monoclonal Antibody for Human Toll-like receptor 8
    Protein for Human Toll-like receptor 8
    Protein for Human Toll-like receptor 8

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
      Du X. , Poltorak A. , Wei Y. , Beutler B.
      Eur. Cytokine Netw.11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Placenta.
    2. 2.
      "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
      Chuang T.-H. , Ulevitch R.J.
      Eur. Cytokine Netw.11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
      Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P. , Macquin C. , Bahram S.
      PLoS ONE4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."
      Doyle S.L. , Jefferies C.A. , Feighery C. , O'Neill L.A.
      J. Biol. Chem.282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BTK
    10. 10.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-88
      tissue: Liver.
    11. 11.
      "Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands."
      Tanji H. , Ohto U. , Shibata T. , Miyake K. , Shimizu T.
      Science339:1426-1429(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 27-827 IN COMPLEXES WITH RESIQUIMOD AND OTHER SYNTHETIC AGONISTS;FUNCTION;SUBUNIT;LEUCINE-RICH REPEATS;MUTAGENESIS OF TYR-348; VAL-378; PHE-405 AND ASP-543;GLYCOSYLATION AT ASN-293; ASN-395; ASN-511; VAL-520; ASN-546; THR-574; ASN-590; ASN-640 AND ASN-680;DISULFIDE BONDS
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