Gene name:
TLR8 (UNQ249/PRO286) ;
Protein name:
Toll-like receptor 8 ;
Alternative:
CD:
CD288 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Interacts with BTK.
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MENMFLQSSM | LTCIFLLISG | SCELCAEENF | SRSYPCDEKK | QNDSVIAECS |
100:
NRRLQEVPQT | VGKYVTELDL | SDNFITHITN | ESFQGLQNLT | KINLNHNPNV |
150:
QHQNGNPGIQ | SNGLNITDGA | FLNLKNLREL | LLEDNQLPQI | PSGLPESLTE |
200:
LSLIQNNIYN | ITKEGISRLI | NLKNLYLAWN | CYFNKVCEKT | NIEDGVFETL |
250:
TNLELLSLSF | NSLSHVPPKL | PSSLRKLFLS | NTQIKYISEE | DFKGLINLTL |
300:
LDLSGNCPRC | FNAPFPCVPC | DGGASINIDR | FAFQNLTQLR | YLNLSSTSLR |
350:
KINAAWFKNM | PHLKVLDLEF | NYLVGEIASG | AFLTMLPRLE | ILDLSFNYIK |
400:
GSYPQHINIS | RNFSKLLSLR | ALHLRGYVFQ | ELREDDFQPL | MQLPNLSTIN |
450:
LGINFIKQID | FKLFQNFSNL | EIIYLSENRI | SPLVKDTRQS | YANSSSFQRH |
500:
IRKRRSTDFE | FDPHSNFYHF | TRPLIKPQCA | AYGKALDLSL | NSIFFIGPNQ |
550:
FENLPDIACL | NLSANSNAQV | LSGTEFSAIP | HVKYLDLTNN | RLDFDNASAL |
600:
TELSDLEVLD | LSYNSHYFRI | AGVTHHLEFI | QNFTNLKVLN | LSHNNIYTLT |
650:
DKYNLESKSL | VELVFSGNRL | DILWNDDDNR | YISIFKGLKN | LTRLDLSLNR |
700:
LKHIPNEAFL | NLPASLTELH | INDNMLKFFN | WTLLQQFPRL | ELLDLRGNKL |
750:
LFLTDSLSDF | TSSLRTLLLS | HNRISHLPSG | FLSEVSSLKH | LDLSSNLLKT |
800:
INKSALETKT | TTKLSMLELH | GNPFECTCDI | GDFRRWMDEH | LNVKIPRLVD |
850:
VICASPGDQR | GKSIVSLELT | TCVSDVTAVI | LFFFTFFITT | MVMLAALAHH |
900:
LFYWDVWFIY | NVCLAKVKGY | RSLSTSQTFY | DAYISYDTKD | ASVTDWVINE |
950:
LRYHLEESRD | KNVLLCLEER | DWDPGLAIID | NLMQSINQSK | KTVFVLTKKY |
1000:
AKSWNFKTAF | YLALQRLMDE | NMDVIIFILL | EPVLQHSQYL | RLRQRICKSS |
1041:
ILQWPDNPKA | EGLFWQTLRN | VVLTENDSRY | NNMYVDSIKQ | Y
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Toll-like receptor 8
ELISA Kit for Human Toll-like receptor 8
CLIA Kit for Human Toll-like receptor 8
CLIA Kit for Human Toll-like receptor 8
Polyclonal Antibody for Human Toll-like receptor 8
Polyclonal Antibody for Human Toll-like receptor 8
Monoclonal Antibody for Human Toll-like receptor 8
Monoclonal Antibody for Human Toll-like receptor 8
Protein for Human Toll-like receptor 8
Protein for Human Toll-like receptor 8
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.
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Cited for : FUNCTION;INTERACTION WITH BTK
10.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-88
tissue :
Liver .
11.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 27-827 IN COMPLEXES WITH RESIQUIMOD AND OTHER SYNTHETIC AGONISTS;FUNCTION;SUBUNIT;LEUCINE-RICH REPEATS;MUTAGENESIS OF TYR-348; VAL-378; PHE-405 AND ASP-543;GLYCOSYLATION AT ASN-293; ASN-395; ASN-511; VAL-520; ASN-546; THR-574; ASN-590; ASN-640 AND ASN-680;DISULFIDE BONDS