Tlr9 ELISA Kit for Mouse(Mus musculus) | EIAab.comTlr9 ELISA Kit for Mouse(Mus musculus)

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Tlr9 (Gene name),

Toll-like receptor 9 (Protein name ), TLR9_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tlr9;

Protein name:

Toll-like receptor 9;

Alternative:

CD:

CD289;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts with CNPY3. Interacts (via transmembrane domain) with UNC93B1.

Function:

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle phagosome Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Protein Attributes:

Sequence length:

1032

Sequence:

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1032:

GQGGFWAQLS | TALTRDNRHF | YNQNFCRGPT | AE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000082207

KEGG:

mmu:81897

SMR:

Q9EQU3

UniGene:

Mm.44889

String:

Q9EQU3

Pfam:

PF00560

Uniprot:

Q9EQU3

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ELISA Kit for Mouse Toll-like receptor 9

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E0709h

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96T

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ELISA Kit for Mouse Toll-like receptor 9

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E0709p

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96T

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ELISA Kit for Mouse Toll-like receptor 9

Cat.:

E0709d

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96T

ELISA Kit for Mouse Toll-like receptor 9

Cat.:

E0709m

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96T

ELISA Kit for Mouse Toll-like receptor 9

Cat.:

E0709b

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96T

CLIA Kit for Mouse Toll-like receptor 9

Cat.:

U0709p

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96T

CLIA Kit for Mouse Toll-like receptor 9

Cat.:

U0709h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Toll-like receptor 9

Cat.:

U0709b

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96T

CLIA Kit for Mouse Toll-like receptor 9

Cat.:

U0709d

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Packing:

96T

CLIA Kit for Mouse Toll-like receptor 9

Cat.:

U0709m

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Packing:

96T

Polyclonal Antibody for Mouse Toll-like receptor 9

Cat.:

P0709Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Toll-like receptor 9

Cat.:

P0709Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Toll-like receptor 9

Monoclonal Antibody for Mouse Toll-like receptor 9

Protein for Mouse Toll-like receptor 9

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A Toll-like receptor recognizes bacterial DNA."
Hemmi H. , Takeuchi O. , Kawai T. , Kaisho T. , Sato S. , Sanjo H. , Matsumoto M. , Hoshino K. , Wagner H. , Takeda K. , Akira S.
Nature408:740-745(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition."
Bauer S.M. , Kirschning C.J. , Hacker H. , Redecke V. , Hausmann S. , Akira S. , Wagner H. , Lipford G.B.
Proc. Natl. Acad. Sci. U.S.A.98:9237-9242(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Macrophage.
3.

"Toll-like receptor 9 mediates CpG-DNA signaling."
Chuang T.-H. , Lee J. , Kline L. , Mathison J.C. , Ulevitch R.J.
J. Leukoc. Biol.71:538-544(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan."
Anderson A.E. , Worku M.L. , Khamri W. , Bamford K.B. , Walker M.M. , Thursz M.R.
Eur. J. Immunol.37:1548-1561(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-964;FUNCTION;TISSUE SPECIFICITY;INDUCTION;DISRUPTION PHENOTYPE
strain: BALB/c.
strain: C57BL/6.
6.

"Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection."
Tabeta K. , Georgel P. , Janssen E. , Du X. , Hoebe K. , Crozat K. , Mudd S. , Shamel L. , Sovath S. , Goode J. , Alexopoulou L. , Flavell R.A. , Beutler B.
Proc. Natl. Acad. Sci. U.S.A.101:3516-3521(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOMEGALOVIRUS INFECTION;MUTAGENESIS OF LEU-499
7.

"The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling."
Brinkmann M.M. , Spooner E. , Hoebe K. , Beutler B. , Ploegh H.L. , Kim Y.M.
J. Cell Biol.177:265-275(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH UNC93B1
8.

"A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors."
Kiyokawa T. , Akashi-Takamura S. , Shibata T. , Matsumoto F. , Nishitani C. , Kuroki Y. , Seto Y. , Miyake K.
Int. Immunol.20:1407-1415(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNPY3
9.

"UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes."
Kim Y.M. , Brinkmann M.M. , Paquet M.E. , Ploegh H.L.
Nature452:234-238(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
10.

"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B. , Yang Y. , Qiu Z. , Staron M. , Hong F. , Li Y. , Wu S. , Li Y. , Hao B. , Bona R. , Han D. , Li Z.
Nat. Commun.1:79-79(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNPY3 AND HSP90B1
11.

Liu B. , Yang Y. , Qiu Z. , Staron M. , Hong F. , Li Y. , Wu S. , Li Y. , Hao B. , Bona R. , Han D. , Li Z.
Nat. Commun.3:653-653(2012)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
12.

"CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination."
Wu Y. , Zhu X. , Li N. , Chen T. , Yang M. , Yao M. , Liu X. , Jin B. , Wang X. , Cao X.
J. Immunol.187:4881-4889(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD300LH

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