Protein name:
Toll-like receptor 9 ;
Alternative:
CD:
CD289 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts with CNPY3. Interacts (via transmembrane domain) with UNC93B1.
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Endosome
Lysosome
Cytoplasmic vesicle
phagosome
Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Protein Attributes:
50:
MVLRRRTLHP | LSLLVQAAVL | AETLALGTLP | AFLPCELKPH | GLVDCNWLFL |
100:
KSVPRFSAAA | SCSNITRLSL | ISNRIHHLHN | SDFVHLSNLR | QLNLKWNCPP |
150:
TGLSPLHFSC | HMTIEPRTFL | AMRTLEELNL | SYNGITTVPR | LPSSLVNLSL |
200:
SHTNILVLDA | NSLAGLYSLR | VLFMDGNCYY | KNPCTGAVKV | TPGALLGLSN |
250:
LTHLSLKYNN | LTKVPRQLPP | SLEYLLVSYN | LIVKLGPEDL | ANLTSLRVLD |
300:
VGGNCRRCDH | APNPCIECGQ | KSLHLHPETF | HHLSHLEGLV | LKDSSLHTLN |
350:
SSWFQGLVNL | SVLDLSENFL | YESINHTNAF | QNLTRLRKLN | LSFNYRKKVS |
400:
FARLHLASSF | KNLVSLQELN | MNGIFFRSLN | KYTLRWLADL | PKLHTLHLQM |
450:
NFINQAQLSI | FGTFRALRFV | DLSDNRISGP | STLSEATPEE | ADDAEQEELL |
500:
SADPHPAPLS | TPASKNFMDR | CKNFKFTMDL | SRNNLVTIKP | EMFVNLSRLQ |
550:
CLSLSHNSIA | QAVNGSQFLP | LTNLQVLDLS | HNKLDLYHWK | SFSELPQLQA |
600:
LDLSYNSQPF | SMKGIGHNFS | FVAHLSMLHS | LSLAHNDIHT | RVSSHLNSNS |
650:
VRFLDFSGNG | MGRMWDEGGL | YLHFFQGLSG | LLKLDLSQNN | LHILRPQNLD |
700:
NLPKSLKLLS | LRDNYLSFFN | WTSLSFLPNL | EVLDLAGNQL | KALTNGTLPN |
750:
GTLLQKLDVS | SNSIVSVVPA | FFALAVELKE | VNLSHNILKT | VDRSWFGPIV |
800:
MNLTVLDVRS | NPLHCACGAA | FVDLLLEVQT | KVPGLANGVK | CGSPGQLQGR |
850:
SIFAQDLRLC | LDEVLSWDCF | GLSLLAVAVG | MVVPILHHLC | GWDVWYCFHL |
900:
CLAWLPLLAR | SRRSAQALPY | DAFVVFDKAQ | SAVADWVYNE | LRVRLEERRG |
950:
RRALRLCLED | RDWLPGQTLF | ENLWASIYGS | RKTLFVLAHT | DRVSGLLRTS |
1000:
FLLAQQRLLE | DRKDVVVLVI | LRPDAHRSRY | VRLRQRLCRQ | SVLFWPQQPN |
1032:
GQGGFWAQLS | TALTRDNRHF | YNQNFCRGPT | AE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Dog
Mouse
Bovine
ELISA Kit for Mouse Toll-like receptor 9
ELISA Kit for Mouse Toll-like receptor 9
ELISA Kit for Mouse Toll-like receptor 9
ELISA Kit for Mouse Toll-like receptor 9
ELISA Kit for Mouse Toll-like receptor 9
CLIA Kit for Mouse Toll-like receptor 9
CLIA Kit for Mouse Toll-like receptor 9
CLIA Kit for Mouse Toll-like receptor 9
CLIA Kit for Mouse Toll-like receptor 9
CLIA Kit for Mouse Toll-like receptor 9
Polyclonal Antibody for Mouse Toll-like receptor 9
Polyclonal Antibody for Mouse Toll-like receptor 9
Polyclonal Antibody for Mouse Toll-like receptor 9
Polyclonal Antibody for Mouse Toll-like receptor 9
Polyclonal Antibody for Mouse Toll-like receptor 9
Monoclonal Antibody for Mouse Toll-like receptor 9
Monoclonal Antibody for Mouse Toll-like receptor 9
Monoclonal Antibody for Mouse Toll-like receptor 9
Monoclonal Antibody for Mouse Toll-like receptor 9
Monoclonal Antibody for Mouse Toll-like receptor 9
Protein for Mouse Toll-like receptor 9
Protein for Mouse Toll-like receptor 9
Protein for Mouse Toll-like receptor 9
Protein for Mouse Toll-like receptor 9
Protein for Mouse Toll-like receptor 9
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A Toll-like receptor recognizes bacterial DNA."
Hemmi H.
,
Takeuchi O.
,
Kawai T.
,
Kaisho T.
,
Sato S.
,
Sanjo H.
,
Matsumoto M.
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Wagner H.
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Akira S.
Nature408:740-745(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Macrophage .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
4.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
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Agarwala R.
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Cherry J.L.
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DiCuccio M.
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Hlavina W.
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Kapustin Y.
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Meric P.
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Maglott D.
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Birtle Z.
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Marques A.C.
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Graves T.
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Zhou S.
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Teague B.
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Potamousis K.
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Churas C.
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Place M.
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Herschleb J.
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Runnheim R.
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Forrest D.
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Amos-Landgraf J.
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Schwartz D.C.
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Cheng Z.
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Eichler E.E.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-964;FUNCTION;TISSUE SPECIFICITY;INDUCTION;DISRUPTION PHENOTYPE
strain :
BALB/c .
strain :
C57BL/6 .
6.
"Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection."
Tabeta K.
,
Georgel P.
,
Janssen E.
,
Du X.
,
Hoebe K.
,
Crozat K.
,
Mudd S.
,
Shamel L.
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Sovath S.
,
Goode J.
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Alexopoulou L.
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Flavell R.A.
,
Beutler B.
Proc. Natl. Acad. Sci. U.S.A.101:3516-3521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CYTOMEGALOVIRUS INFECTION;MUTAGENESIS OF LEU-499
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH UNC93B1
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CNPY3
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
10.
"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B.
,
Yang Y.
,
Qiu Z.
,
Staron M.
,
Hong F.
,
Li Y.
,
Wu S.
,
Li Y.
,
Hao B.
,
Bona R.
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Han D.
,
Li Z.
Nat. Commun.1:79-79(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CNPY3 AND HSP90B1
11.
Liu B.
,
Yang Y.
,
Qiu Z.
,
Staron M.
,
Hong F.
,
Li Y.
,
Wu S.
,
Li Y.
,
Hao B.
,
Bona R.
,
Han D.
,
Li Z.
Nat. Commun.3:653-653(2012)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CD300LH