TNFAIP3 ELISA Kit for Human(Homo sapiens) | EIAab.comTNFAIP3 ELISA Kit for Human(Homo sapiens) | EIAab.com

Language:

[Sign in] [Register]

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > TNFAIP3(Gene name) > Human

Add your favorite

TNFAIP3 (Gene name),

Tumor necrosis factor alpha-induced protein 3 (Protein name ), TNAP3_HUMAN from NCBI database.

top

Come back to page head.

|

General Annotation

|

Antigen Annotation

|

3D

|

Predicted Eptitope

|

Vaild Sequence

|

Related Databases

|

Feedback

Gene name:

TNFAIP3(OTUD7C);

Protein name:

Tumor necrosis factor alpha-induced protein 3(TNF alpha-induced protein 3);

Alternative:

Putative DNA-binding protein A20;OTU domain-containing protein 7C;Zinc finger protein A20;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF.

Function:

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

790

Sequence:

50:

MAEQVLPQAL | YLSNMRKAVK | IRERTPEDIF | KPTNGIIHHF | KTMHRYTLEM |

100:

FRTCQFCPQF | REIIHKALID | RNIQATLESQ | KKLNWCREVR | KLVALKTNGD |

150:

GNCLMHATSQ | YMWGVQDTDL | VLRKALFSTL | KETDTRNFKF | RWQLESLKSQ |

200:

EFVETGLCYD | TRNWNDEWDN | LIKMASTDTP | MARSGLQYNS | LEEIHIFVLC |

250:

NILRRPIIVI | SDKMLRSLES | GSNFAPLKVG | GIYLPLHWPA | QECYRYPIVL |

300:

GYDSHHFVPL | VTLKDSGPEI | RAVPLVNRDR | GRFEDLKVHF | LTDPENEMKE |

350:

KLLKEYLMVI | EIPVQGWDHG | TTHLINAAKL | DEANLPKEIN | LVDDYFELVQ |

400:

HEYKKWQENS | EQGRREGHAQ | NPMEPSVPQL | SLMDVKCETP | NCPFFMSVNT |

450:

QPLCHECSER | RQKNQNKLPK | LNSKPGPEGL | PGMALGASRG | EAYEPLAWNP |

500:

EESTGGPHSA | PPTAPSPFLF | SETTAMKCRS | PGCPFTLNVQ | HNGFCERCHN |

550:

ARQLHASHAP | DHTRHLDPGK | CQACLQDVTR | TFNGICSTCF | KRTTAEASSS |

600:

LSTSLPPSCH | QRSKSDPSRL | VRSPSPHSCH | RAGNDAPAGC | LSQAARTPGD |

650:

RTGTSKCRKA | GCVYFGTPEN | KGFCTLCFIE | YRENKHFAAA | SGKVSPTASR |

700:

FQNTIPCLGR | ECGTLGSTMF | EGYCQKCFIE | AQNQRFHEAK | RTEEQLRSSQ |

750:

RRDVPRTTQS | TSRPKCARAS | CKNILACRSE | ELCMECQHPN | QRMGPGAHRG |

790:

EPAPEDPPKQ | RCRAPACDHF | GNAKCNGYCN | ECFQFKQMYG |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

String:

SMR:

STRING:

9606.ENSP00000237289

KEGG:

UniGene:

MIM:

Uniprot:

FOR

ELISA Kit for Human TNF alpha-induced protein 3

Cat.:

E9843h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human TNF alpha-induced protein 3

Cat.:

E9843m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human TNF alpha-induced protein 3

Cat.:

U9843h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human TNF alpha-induced protein 3

Cat.:

U9843m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human TNF alpha-induced protein 3

Cat.:

P9843Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human TNF alpha-induced protein 3

Cat.:

P9843Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human TNF alpha-induced protein 3

Monoclonal Antibody for Human TNF alpha-induced protein 3

Protein for Human TNF alpha-induced protein 3

Protein for Human TNF alpha-induced protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

s

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤8.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.2%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of TNAP3 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	98	90-104
Plasma	99	91-107

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TNAP3 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	90-105%	93-102%	95-100%	92-106%
Saliva(n=3)	92-106%	91-108%	90-107%	90-110%
heparin plasma(n=5)	93-104%	94-102%	96-103%	95-101%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
Saliva(n=3)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein."
Opipari A.W. Jr. , Boguski M.S. , Dixit V.M.
J. Biol. Chem.265:14705-14708(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Trachea.
3.

SeattleSNPs variation discovery resource
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-125; CYS-127 AND PRO-766
4.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-790
tissue: Testis.
8.

"The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation."
Song H.Y. , Rothe M. , Goeddel D.V.
Proc. Natl. Acad. Sci. U.S.A.93:6721-6725(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRAF1 AND TRAF2
9.

"A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins."
De Valck D. , Heyninck K. , Van Criekinge W. , Vandenabeele P. , Fiers W. , Beyaert R.
Biochem. Biophys. Res. Commun.238:590-594(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH YWHAZ AND YWHAH;MUTAGENESIS OF ARG-562 AND SER-565
10.

"Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C-terminus via a mechanism involving TRADD and TRAF2."
Eliopoulos A.G. , Blake S.M. , Floettmann J.E. , Rowe M. , Young L.S.
J. Virol.73:1023-1035(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRAF2
11.

"The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases."
de Valck D. , Jin D.-Y. , Heyninck K. , van de Craen M. , Contreras R. , Fiers W. , Jeang K.-T. , Beyaert R.
Oncogene18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAX1BP1
12.

"Isolation and characterization of two novel A20-like proteins."
Evans P.C. , Taylor E.R. , Coadwell J. , Heyninck K. , Beyaert R. , Kilshaw P.J.
Biochem. J.357:617-623(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
13.

"Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity."
Evans P.C. , Ovaa H. , Hamon M. , Kilshaw P.J. , Hamm S. , Bauer S. , Ploegh H.L. , Smith T.S.
Biochem. J.378:727-734(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-103
14.

"De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling."
Wertz I.E. , O'Rourke K.M. , Zhou H. , Eby M. , Aravind L. , Seshagiri S. , Wu P. , Wiesmann C. , Baker R. , Boone D.L. , Ma A. , Koonin E.V. , Dixit V.M.
Nature430:694-699(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN OTU;DOMAIN A20-TYPE ZINC-FINGER;MUTAGENESIS OF CYS-103; CYS-521; CYS-524; CYS-624 AND CYS-627
15.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB."
Mauro C. , Pacifico F. , Lavorgna A. , Mellone S. , Iannetti A. , Acquaviva R. , Formisano S. , Vito P. , Leonardi A.
J. Biol. Chem.281:18482-18488(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IKBKG AND TNIP1
17.

"T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20."
Coornaert B. , Baens M. , Heyninck K. , Bekaert T. , Haegman M. , Staal J. , Sun L. , Chen Z.J. , Marynen P. , Beyaert R.
Nat. Immunol.9:263-271(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation."
Li L. , Soetandyo N. , Wang Q. , Ye Y.
Biochim. Biophys. Acta1793:346-353(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
20.

"The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."
Shembade N. , Parvatiyar K. , Harhaj N.S. , Harhaj E.W.
EMBO J.28:513-522(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAX1BP1; RNF11 AND RIPK1
21.

"A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains."
Duwel M. , Welteke V. , Oeckinghaus A. , Baens M. , Kloo B. , Ferch U. , Darnay B.G. , Ruland J. , Marynen P. , Krappmann D.
J. Immunol.182:7718-7728(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-459;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
23.

"Cleavage by MALT1 induces cytosolic release of A20."
Malinverni C. , Unterreiner A. , Staal J. , Demeyer A. , Galaup M. , Luyten M. , Beyaert R. , Bornancin F.
Biochem. Biophys. Res. Commun.400:543-547(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION
24.

"Direct, noncatalytic mechanism of IKK inhibition by A20."
Skaug B. , Chen J. , Du F. , He J. , Ma A. , Chen Z.J.
Mol. Cell44:559-571(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IKBKG;MUTAGENESIS OF 770-PHE-GLY-771; CYS-779 AND CYS-782
25.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
26.

"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
Mevissen T.E. , Hospenthal M.K. , Geurink P.P. , Elliott P.R. , Akutsu M. , Arnaudo N. , Ekkebus R. , Kulathu Y. , Wauer T. , El Oualid F. , Freund S.M. , Ovaa H. , Komander D.
Cell154:169-184(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
27.

"Solution structure of the A20-type zinc finger domains from human tumor necrosis factor, alpha-induced protein 3."
RIKEN structural genomics initiative (RSGI)
Submitted (2007-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 381-790
28.

"Structure of the A20 OTU domain and mechanistic insights into deubiquitination."
Komander D. , Barford D.
Biochem. J.409:77-85(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 1-366;CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF ASP-70; CYS-103 AND HIS-256
29.

"Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20."
Lin S.C. , Chung J.Y. , Lamothe B. , Rajashankar K. , Lu M. , Lo Y.C. , Lam A.Y. , Darnay B.G. , Wu H.
J. Mol. Biol.376:526-540(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-370;ACTIVE SITE;CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF ASP-70; THR-97; ASP-100; CYS-103; LEU-157; TYR-159; SER-190; GLU-192; PHE-224 AND LEU-227
30.

"Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling."
Bosanac I. , Wertz I.E. , Pan B. , Yu C. , Kusam S. , Lam C. , Phu L. , Phung Q. , Maurer B. , Arnott D. , Kirkpatrick D.S. , Dixit V.M. , Hymowitz S.G.
Mol. Cell40:548-557(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 592-635 IN COMPLEX WITH UBIQUITIN;X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 592-635 IN COMPLEX WITH UBIQUITIN AND UBE2D1;MUTAGENESIS OF TYR-614; PHE-615 AND LEU-626

Product Feedback Wall

Hot Genes: Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5

Top Searches: Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Tumor necrosis Alpha Asprosin TRAP1A

Why choose EIAAB: Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more

Further Information: About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved EIAab Email:eiaab@eiaab.com

鄂ICP备10015095号-1

鄂公网安备 42018502005535号