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Index > Protein center > TNFSF13(Gene name) > Human
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  • TNFSF13 (Gene name),
  • Tumor necrosis factor ligand superfamily member 13 (Protein name ),  TNF13_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TNFSF13(UNQ383/PRO715;APRIL;TALL2;ZTNF2);
    Protein name:
    Tumor necrosis factor ligand superfamily member 13;
    Alternative:
    TNF- and APOL-related leukocyte expressed ligand 2(TALL-2);A proliferation-inducing ligand(APRIL);TNF-related death ligand 1(TRDL-1);
    CD:
    CD256;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    250
    Sequence:
    50:
    MPASSPFLLA | PKGPPGNMGG | PVREPALSVA | LWLSWGAALG | AVACAMALLT | 
    100:
    QQTELQSLRR | EVSRLQGTGG | PSQNGEGYPW | QSLPEQSSDA | LEAWENGERS | 
    150:
    RKRRAVLTQK | QKKQHSVLHL | VPINATSKDD | SDVTEVMWQP | ALRRGRGLQA | 
    200:
    QGYGVRIQDA | GVYLLYSQVL | FQDVTFTMGQ | VVSREGQGRQ | ETLFRCIRSM | 
    250:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    E1750m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    E1750h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    U1750h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    U1750m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    P1750Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 13
    Cat.:
    P1750Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 13
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 13
    Protein for Human Tumor necrosis factor ligand superfamily member 13
    Protein for Human Tumor necrosis factor ligand superfamily member 13

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth."
      Hahne M. , Kataoka T. , Schroeter M. , Hofmann K. , Irmler M. , Bodmer J.-L. , Schneider P. , Bornand T. , Holler N. , French L.E. , Sordat B. , Rimoldi D. , Tschopp J.
      J. Exp. Med.188:1185-1190(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Uterus.
    2. 2.
      "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens."
      Shu H.-B. , Hu W.-H. , Johnson H.
      J. Leukoc. Biol.65:680-683(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Homo sapiens tumor necrosis factor homolog."
      Farrah T. , Grant F. , Haldeman B. , Whitmore T. , Gross J. , O'Hara P.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death."
      Kelly K.A. , Manos E.J. , Jensen G.T. , Nadauld L. , Jones D.A.
      Cancer Res.60:1021-1027(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA)
    5. 5.
      "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein."
      Pradet-Balade B. , Medema J.P. , Lopez-Fraga M. , Lozano J.C. , Kolfschoten G.M. , Picard A. , Martinez-A C. , Garcia-Sanz J.A. , Hahne M.
      EMBO J.21:5711-5720(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
    6. 6.
      "Polymorphisms of human APRIL gene."
      Kawasaki A. , Tsuchiya N. , Kusaoi M. , Murakami T. , Fukazawa T. , Matsuta K. , Hashimoto H. , Tokunaga K.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Spleen.
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT ARG-67
    10. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA);VARIANT SER-96
      tissue: Ovary.
    11. 12.
      "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."
      Yu G. , Boone T. , Delaney J. , Hawkins N. , Kelley M.J. , Ramakrishnan M. , McCabe S. , Qiu W.R. , Kornuc M. , Xia X.-Z. , Guo J. , Stolina M. , Boyle W.J. , Sarosi I. , Hsu H. , Senaldi G. , Theill L.E.
      Nat. Immunol.1:252-256(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 13.
      "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase."
      Lopez-Fraga M. , Fernandez R. , Albar J.P. , Hahne M.
      EMBO Rep.2:945-951(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY FURIN;MUTAGENESIS OF 101-ARG--ARG-104;SUBCELLULAR LOCATION
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