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Index > Protein center > TNFSF14(Gene name) > Human
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  • TNFSF14 (Gene name),
  • Tumor necrosis factor ligand superfamily member 14 (Protein name ),  TNF14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TNFSF14(UNQ391/PRO726;HVEML;LIGHT);
    Protein name:
    Tumor necrosis factor ligand superfamily member 14;
    Alternative:
    Herpes virus entry mediator ligand(HVEM-L;Herpesvirus entry mediator ligand);
    CD:
    CD258;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
    Subcellular Location:
    Isoform 2 Cytoplasm
    Protein Attributes:
    Sequence length:
    240
    Sequence:
    50:
    MEESVVRPSV | FVVDGQTDIP | FTRLGRSHRR | QSCSVARVGL | GLLLLLMGAG | 
    100:
    LAVQGWFLLQ | LHWRLGEMVT | RLPDGPAGSW | EQLIQERRSH | EVNPAAHLTG | 
    150:
    ANSSLTGSGG | PLLWETQLGL | AFLRGLSYHD | GALVVTKAGY | YYIYSKVQLG | 
    200:
    GVGCPLGLAS | TITHGLYKRT | PRYPEELELL | VSQQSPCGRA | TSSSRVWWDS | 
    240:
    SFLGGVVHLE | AGEKVVVRVL | DERLVRLRDG | TRSYFGAFMV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    SMR:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    E2060h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    E2060m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    U2060h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    U2060m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    P2060Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 14
    Cat.:
    P2060Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 14
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 14
    Protein for Human Tumor necrosis factor ligand superfamily member 14
    Protein for Human Tumor necrosis factor ligand superfamily member 14

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator."
      Mauri D.N. , Ebner R. , Montgomery R.I. , Kochel K.D. , Cheung T.C. , Yu G.-L. , Ruben S. , Murphy M. , Eisenberg R.J. , Cohen G.H. , Spear P.G. , Ware C.F.
      Immunity8:21-30(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-214
    2. 2.
      "Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth."
      Harrop J.A. , McDonnell P.C. , Brigham-Burke M. , Lyn S.D. , Minton J. , Tan K.B. , Dede K. , Spampanato J. , Silverman C. , Hensley P. , DiPrinzio R. , Emery J.G. , Deen K. , Eichman C. , Chabot-Fletcher M. , Truneh A. , Young P.R.
      J. Biol. Chem.273:27548-27556(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION
      tissue: Liver.
    3. 3.
      "Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis."
      Granger S.W. , Butrovich K.D. , Houshmand P. , Edwards W.R. , Ware C.F.
      J. Immunol.167:5122-5128(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEOLYTIC PROCESSING;VARIANT GLU-214
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-214
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-214
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-214
    9. 9.
      "Crystal structure of LIGHT."
      New York structural genomics research consortium (NYSGRC)
      Submitted (2012-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 83-240;GLYCOSYLATION AT ASN-102;DISULFIDE BOND
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