TNNC1 ELISA Kit for Human(Homo sapiens) | EIAab.comTNNC1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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TNNC1 (Gene name),

Troponin C, slow skeletal and cardiac muscles (Protein name ), TNNC1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

TNNC1(TNNC);

Protein name:

Troponin C, slow skeletal and cardiac muscles(TN-C);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

161

Sequence:

50:

MDDIYKAAVE | QLTEEQKNEF | KAAFDIFVLG | AEDGCISTKE | LGKVMRMLGQ |

100:

NPTPEELQEM | IDEVDEDGSG | TVDFDEFLVM | MVRCMKDDSK | GKSEEELSDL |

150:

FRMFDKNADG | YIDLDELKIM | LQATGETITE | DDIEELMKDG | DKNNDGRIDY |

161:

DEFLEFMKGV | E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

MIM:

Pfam:

STRING:

9606.ENSP00000232975

UniGene:

SMR:

Pfam:

String:

Uniprot:

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ELISA Kit for Human TN-C

MSDS:

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ELISA Kit for Human TN-C

MSDS:

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ELISA Kit for Human TN-C

MSDS:

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ELISA Kit for Human TN-C

Cat.:

E15120h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human TN-C

Cat.:

E15120m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human TN-C

MSDS:

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CLIA Kit for Human TN-C

MSDS:

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CLIA Kit for Human TN-C

MSDS:

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CLIA Kit for Human TN-C

MSDS:

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CLIA Kit for Human TN-C

MSDS:

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CLIA Kit for Human TN-C

Cat.:

U15120h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TN-C

Cat.:

U15120m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human TN-C

Cat.:

P15120Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TN-C

Polyclonal Antibody for Human TN-C

Polyclonal Antibody for Human TN-C

Polyclonal Antibody for Human TN-C

Polyclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Monoclonal Antibody for Human TN-C

Protein for Human TN-C

Protein for Human TN-C

Protein for Human TN-C

Protein for Human TN-C

Protein for Human TN-C

Protein for Human TN-C

Cat.:

R15120h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

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12% SDS-PAGE analysis

12% SDS-PAGE analysis

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Precision

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Recovery

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Linearity

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References

1.

"The amino acid sequence of human cardiac troponin-C."
Roher A. , Lieska N. , Spitz W.
Muscle Nerve9:73-77(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE;ACETYLATION AT MET-1
tissue: Heart muscle.
2.

"Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts."
Gahlmann R. , Wade R. , Gunning R. , Kedes L.
J. Mol. Biol.201:379-391(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Slow skeletal muscle.
3.

"Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene."
Schreier T. , Kedes L. , Gahlmann R.
J. Biol. Chem.265:21247-21253(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Slow skeletal muscle.
4.

"H. sapiens mRNA for cardiac ventricular troponin C in idiopathic dilated cardiomyopathy."
Margossian S.S. , Yang F. , Umeda P.K. , Sciaky D. , Anderson P.A.W.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Blood.
6.

"Calcium-induced structural transition in the regulatory domain of human cardiac troponin C."
Spyracopoulos L. , Li M.X. , Sia S.K. , Gagne S.M. , Chandra M. , Solaro R.J. , Sykes B.D.
Biochemistry36:12138-12146(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-89
tissue: Heart muscle.
7.

"Structural and functional domains of the troponin complex revealed by limited digestion."
Takeda S. , Kobayashi T. , Taniguchi H. , Hayashi H. , Maeda Y.
Eur. J. Biochem.246:611-617(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS)
8.

"Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I."
Lindhout D.A. , Sykes B.D.
J. Biol. Chem.278:27024-27034(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 89-161
tissue: Heart muscle.
9.

"First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy."
Hoffmann B. , Schmidt-Traub H. , Perrot A. , Osterziel K.J. , Gessner R.
Hum. Mutat.17:524-524(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMH13 GLN-29
10.

"Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy."
Mogensen J. , Murphy R.T. , Shaw T. , Bahl A. , Redwood C. , Watkins H. , Burke M. , Elliott P.M. , McKenna W.J.
J. Am. Coll. Cardiol.44:2033-2040(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1Z ARG-159
11.

"Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C."
Schmidtmann A. , Lindow C. , Villard S. , Heuser A. , Mugge A. , Gessner R. , Granier C. , Jaquet K.
FEBS J.272:6087-6097(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT CMH13 GLN-29
12.

"Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C."
Landstrom A.P. , Parvatiyar M.S. , Pinto J.R. , Marquardt M.L. , Bos J.M. , Tester D.J. , Ommen S.R. , Potter J.D. , Ackerman M.J.
J. Mol. Cell. Cardiol.45:281-288(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH13 VAL-8; TYR-84; ASP-134 AND GLU-145;CHARACTERIZATION OF VARIANTS CMH13 VAL-8; TYR-84; ASP-134 AND GLU-145
13.

"A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy."
Pinto J.R. , Parvatiyar M.S. , Jones M.A. , Liang J. , Ackerman M.J. , Potter J.D.
J. Biol. Chem.284:19090-19100(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CMH13 VAL-8; TYR-84; ASP-134 AND GLU-145

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