TNFRSF11A ELISA Kit for Human(Homo sapiens) | EIAab.comTNFRSF11A ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > TNFRSF11A(Gene name) > Human

TNFRSF11A (Gene name),

Tumor necrosis factor receptor superfamily member 11A (Protein name ), TNR11_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

TNFRSF11A(RANK);

Protein name:

Tumor necrosis factor receptor superfamily member 11A;

Alternative:

Receptor activator of NF-KB;Osteoclast differentiation factor receptor(ODFR);

CD:

CD265;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.

Function:

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

616

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

616:

PEKASRPVQE | QGGAKA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.204044

KEGG:

hsa:8792

STRING:

9606.ENSP00000269485

MIM:

174810

SMR:

Q9Y6Q6

String:

Q9Y6Q6

Pfam:

PF00020

Uniprot:

Q9Y6Q6

FOR

ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

E2057h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

E2057m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

U2057m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

U2057h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

P2057Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11A

Cat.:

P2057Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11A

Protein for Human Tumor necrosis factor receptor superfamily member 11A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
Anderson D.M. , Maraskovsky E. , Billingsley W.L. , Dougall W.C. , Tometsko M.E. , Roux E.R. , Teepe M.C. , DuBose R.F. , Cosman D. , Galibert L.
Nature390:175-179(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Dendritic cell.
2.

"Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB."
Sirinian C. , Papanastasiou A.D. , Zarkadis I.K. , Kalofonos H.P.
Gene525:124-129(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RANK-E5A);SUBCELLULAR LOCATION (ISOFORMS 1 AND RANK-E5A);ALTERNATIVE SPLICING
tissue: Blood.
3.

"Alternative splicing generates multiple human TNFRSF11A (RANK) isoforms."
Papanastasiou A.D. , Sirinian C. , Kalofonos H.P.
Submitted (2012-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);NUCLEOTIDE SEQUENCE [MRNA] OF 159-523 (ISOFORM 5);ALTERNATIVE SPLICING
tissue: Blood.
4.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
5.

"RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis."
Nakagawa N. , Kinosaki M. , Yamaguchi K. , Shima N. , Yasuda H. , Yano K. , Morinaga T. , Higashio K.
Biochem. Biophys. Res. Commun.253:395-400(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
Wong B.R. , Josien R. , Lee S.Y. , Vologodskaia M. , Steinman R.M. , Choi Y.
J. Biol. Chem.273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF1; TRAF2; TRAF3; TRAF5 AND TRAF6
7.

"The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
Wada T. , Nakashima T. , Oliveira-dos-Santos A.J. , Gasser J. , Hara H. , Schett G. , Penninger J.M.
Nat. Med.11:394-399(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAB2
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis."
Hughes A.E. , Ralston S.H. , Marken J. , Bell C. , MacPherson H. , Wallace R.G.H. , van Hul W. , Whyte M.P. , Nakatsuka K. , Hovy L. , Anderson D.M.
Nat. Genet.24:45-48(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FEO LEU-LEU-CYS-ALA-LEU-LEU-21 INS;VARIANT PDB2 ALA-LEU-LEU-LEU-LEU-CYS-ALA-LEU-LEU-21 INS;VARIANT VAL-192
10.

"Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations."
Guerrini M.M. , Sobacchi C. , Cassani B. , Abinun M. , Kilic S.S. , Pangrazio A. , Moratto D. , Mazzolari E. , Clayton-Smith J. , Orchard P. , Coxon F.P. , Helfrich M.H. , Crockett J.C. , Mellis D. , Vellodi A. , Tezcan I. , Notarangelo L.D. , Rogers M.J. , more...
Am. J. Hum. Genet.83:64-76(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OPTB7 ARG-53; CYS-129; GLY-170; ARG-175 AND SER-244

Product Feedback Wall

* Email:
*Comments: