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Index > Protein center > TNFRSF12A(Gene name) > Human
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  • TNFRSF12A (Gene name),
  • Tumor necrosis factor receptor superfamily member 12A (Protein name ),  TNR12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TNFRSF12A(FN14);
    Protein name:
    Tumor necrosis factor receptor superfamily member 12A;
    Alternative:
    Tweak-receptor(TweakR);Fibroblast growth factor-inducible immediate-early response protein 14(FGF-inducible 14);
    CD:
    CD266;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with TRAF1 and TRAF2, and probably also with TRAF3.
    Function:
    Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    129
    Sequence:
    50:
    MARGSLRRLL | RLLVLGLWLA | LLRSVAGEQA | PGTAPCSRGS | SWSADLDKCM | 
    100:
    DCASCRARPH | SDFCLGCAAA | PPAPFRLLWP | ILGGALSLTF | VLGLLSGFLV | 
    129:
    WRRCRRREKF | TTPIEETGGE | GCPAVALIQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    MIM:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    E8703h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    E8703m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    U8703h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    U8703m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    P8703Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
    Cat.:
    P8703Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
    Protein for Human Tumor necrosis factor receptor superfamily member 12A
    Protein for Human Tumor necrosis factor receptor superfamily member 12A

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas."
      Feng S.-L.Y. , Guo Y. , Factor V.M. , Thorgeirsson S.S. , Bell D.W. , Testa J.R. , Peifley K.A. , Winkles J.A.
      Am. J. Pathol.156:1253-1261(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Human homologue of Fn14."
      Tanaka S. , Sugimachi K.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Uterus.
    5. 5.
      "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis."
      Wiley S.R. , Cassiano L. , Lofton T. , Davis-Smith T. , Winkles J.A. , Lindner V. , Liu H. , Daniel T.O. , Smith C.A. , Fanslow W.C.
      Immunity15:837-846(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Solution structure of the STN_TNFRSF12A_TNFR domain of tumor necrosis factor receptor superfamily member 12A precursor."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2008-04) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 26-70
    7. 7.
      "Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily."
      He F. , Dang W. , Saito K. , Watanabe S. , Kobayashi N. , Guntert P. , Kigawa T. , Tanaka A. , Muto Y. , Yokoyama S.
      Protein Sci.18:650-656(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 26-70;DISULFIDE BONDS
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