Gene name:
TNFRSF12A (FN14) ;
Protein name:
Tumor necrosis factor receptor superfamily member 12A ;
Alternative:
Tweak-receptor (TweakR) ;Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14) ;
CD:
CD266 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with TRAF1 and TRAF2, and probably also with TRAF3.
Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MARGSLRRLL | RLLVLGLWLA | LLRSVAGEQA | PGTAPCSRGS | SWSADLDKCM |
100:
DCASCRARPH | SDFCLGCAAA | PPAPFRLLWP | ILGGALSLTF | VLGLLSGFLV |
129:
WRRCRRREKF | TTPIEETGGE | GCPAVALIQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 12A
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 12A
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 12A
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 12A
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 12A
Protein for Human Tumor necrosis factor receptor superfamily member 12A
Protein for Human Tumor necrosis factor receptor superfamily member 12A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Placenta .
2.
"Human homologue of Fn14."
Tanaka S.
,
Sugimachi K.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
3.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
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Lippert R.
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Walenz B.
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Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
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Edwards N.J.
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Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Uterus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 26-70
7.
"Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily."
He F.
,
Dang W.
,
Saito K.
,
Watanabe S.
,
Kobayashi N.
,
Guntert P.
,
Kigawa T.
,
Tanaka A.
,
Muto Y.
,
Yokoyama S.
Protein Sci.18:650-656(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 26-70;DISULFIDE BONDS