TOP1 ELISA Kit for Human(Homo sapiens) | EIAab.comTOP1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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TOP1 (Gene name),

DNA topoisomerase 1 (Protein name ), TOP1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

TOP1;

Protein name:

DNA topoisomerase 1;

Alternative:

DNA topoisomerase I;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts with SV40 Large T antigen; this interactions allows viral DNA replication.

Function:

The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Subcellular Location:

Nucleus nucleolus Nucleus nucleoplasm Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.

Protein Attributes:

Sequence length:

765

Sequence:

50:

MSGDHLHNDS | QIEADFRLND | SHKHKDKHKD | REHRHKEHKK | EKDREKSKHS |

100:

NSEHKDSEKK | HKEKEKTKHK | DGSSEKHKDK | HKDRDKEKRK | EEKVRASGDA |

150:

KIKKEKENGF | SSPPQIKDEP | EDDGYFVPPK | EDIKPLKRPR | DEDDADYKPK |

200:

KIKTEDTKKE | KKRKLEEEED | GKLKKPKNKD | KDKKVPEPDN | KKKKPKKEEE |

250:

QKWKWWEEER | YPEGIKWKFL | EHKGPVFAPP | YEPLPENVKF | YYDGKVMKLS |

300:

PKAEEVATFF | AKMLDHEYTT | KEIFRKNFFK | DWRKEMTNEE | KNIITNLSKC |

350:

DFTQMSQYFK | AQTEARKQMS | KEEKLKIKEE | NEKLLKEYGF | CIMDNHKERI |

400:

ANFKIEPPGL | FRGRGNHPKM | GMLKRRIMPE | DIIINCSKDA | KVPSPPPGHK |

450:

WKEVRHDNKV | TWLVSWTENI | QGSIKYIMLN | PSSRIKGEKD | WQKYETARRL |

500:

KKCVDKIRNQ | YREDWKSKEM | KVRQRAVALY | FIDKLALRAG | NEKEEGETAD |

550:

TVGCCSLRVE | HINLHPELDG | QEYVVEFDFL | GKDSIRYYNK | VPVEKRVFKN |

600:

LQLFMENKQP | EDDLFDRLNT | GILNKHLQDL | MEGLTAKVFR | TYNASITLQQ |

650:

QLKELTAPDE | NIPAKILSYN | RANRAVAILC | NHQRAPPKTF | EKSMMNLQTK |

700:

IDAKKEQLAD | ARRDLKSAKA | DAKVMKDAKT | KKVVESKKKA | VQRLEEQLMK |

750:

LEVQATDREE | NKQIALGTSK | LNYLDPRITV | AWCKKWGVPI | EKIYNKTQRE |

765:

KFAWAIDMAD | EDYEF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

STRING:

9606.ENSP00000354522

UniGene:

MIM:

Pfam:

SMR:

KEGG:

String:

Uniprot:

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ELISA Kit for Human DNA topoisomerase 1

Cat.:

E9586m

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96T

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ELISA Kit for Human DNA topoisomerase 1

Cat.:

E9586h

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96T

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ELISA Kit for Human DNA topoisomerase 1

Cat.:

E9586r

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Packing:

96T

CLIA Kit for Human DNA topoisomerase 1

Cat.:

U9586h

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MSDS:

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Packing:

96T

CLIA Kit for Human DNA topoisomerase 1

Cat.:

U9586m

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MSDS:

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Packing:

96T

CLIA Kit for Human DNA topoisomerase 1

Cat.:

U9586r

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96T

Polyclonal Antibody for Human DNA topoisomerase 1

Cat.:

P9586Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human DNA topoisomerase 1

Cat.:

P9586Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human DNA topoisomerase 1

Monoclonal Antibody for Human DNA topoisomerase 1

Monoclonal Antibody for Human DNA topoisomerase 1

Monoclonal Antibody for Human DNA topoisomerase 1

Protein for Human DNA topoisomerase 1

Protein for Human DNA topoisomerase 1

Cat.:

R9586h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human DNA topoisomerase 1

R&D Technical Data

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Western blot-Anti-TOP1 antibody

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤ 4.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤ 7.4%

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Recovery

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	95-102
Plasma	94	93-99

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	90-102%	91-99%	91-104%	89-99%
EDTA plasma(n=5)	87-96%	93-98%	89-95%	90-102%
heparin plasma(n=5)	88-101%	89-102%	91-107%	94-110%

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References

1.

"cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment."
D'Arpa P. , Machlin P.S. , Ratrie H. III , Rothfield N.F. , Cleveland D.W. , Earnshaw W.C.
Proc. Natl. Acad. Sci. U.S.A.85:2543-2547(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY
2.

"Structure of the human type I DNA topoisomerase gene."
Kunze N. , Yang G. , Dolberg M. , Sundarp R. , Knippers R. , Richter A.
J. Biol. Chem.266:9610-9616(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Trachea.
4.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Structural characterisation of the human DNA topoisomerase I gene promoter."
Kunze N. , Klein M. , Richter A. , Knippers R.
Eur. J. Biochem.194:323-330(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14
7.

Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-17; 107-117; 224-239; 253-262; 292-299; 355-362; 426-434; 476-484; 509-532; 550-587; 591-615; 625-634; 656-663; 694-712; 721-734 AND 736-742;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Ovarian carcinoma.
8.

"Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin."
Fujimori A. , Harker W.G. , Kohlhagen G. , Hoki Y. , Pommier Y.
Cancer Res.55:1339-1346(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-765;VARIANTS CPT-RESISTANT LEUKEMIA THR-370 AND SER-722
tissue: Peripheral blood.
9.

"Monoclonal antibodies neutralizing mammalian DNA topoisomerase I activity."
Oddou P. , Schmidt U. , Knippers R. , Richter A.
Eur. J. Biochem.177:523-529(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 344-765
10.

"Characterization of the 3' region of the human DNA topoisomerase I gene."
Zhou B.S. , Bastow K.F. , Cheng Y.C.
Cancer Res.49:3922-3927(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 541-765
11.

"Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis."
Maul G.G. , Jimenez S.A. , Riggs E. , Ziemnicka-Kotula D.
Proc. Natl. Acad. Sci. U.S.A.86:8492-8496(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 657-765
12.

"The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion."
Ahuja H.G. , Felix C.A. , Aplan P.D.
Blood94:3258-3261(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH NUP98
13.

"Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin."
Rallabhandi P. , Hashimoto K. , Mo Y.-Y. , Beck W.T. , Moitra P.K. , D'Arpa P.
J. Biol. Chem.277:40020-40026(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-117;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-103; LYS-117; LYS-153 AND TYR-723
14.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Simian virus 40 DNA replication is dependent on an interaction between topoisomerase I and the C-terminal end of T antigen."
Khopde S. , Simmons D.T.
J. Virol.82:1136-1145(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells."
Eisenreich A. , Bogdanov V.Y. , Zakrzewicz A. , Pries A. , Antoniak S. , Poller W. , Schultheiss H.P. , Rauch U.
Circ. Res.104:589-599(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
19.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-57 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period."
Onishi Y. , Kawano Y.
Nucleic Acids Res.40:9482-9492(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA Binding, and increases cellular camptothecin sensitivity."
Bandyopadhyay K. , Li P. , Gjerset R.A.
PLoS ONE7:E50427-E50427(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-506
25.

"Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA."
Redinbo M.R. , Stewart L. , Kuhn P. , Champoux J.J. , Hol W.G.J.
Science279:1504-1513(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 175-765 IN COMPLEX WITH DNA;ACTIVE SITE
26.

"A model for the mechanism of human topoisomerase I."
Stewart L. , Redinbo M.R. , Qiu X. , Hol W.G.J. , Champoux J.J.
Science279:1534-1541(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 215-765 OF MUTANT PHE-723 IN COMPLEX WITH DNA
27.

"Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA."
Redinbo M.R. , Champoux J.J. , Hol W.G.J.
Biochemistry39:6832-6840(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 203-765 IN COMPLEX WITH DNA;ACTIVE SITE
28.

"8-Oxoguanine rearranges the active site of human topoisomerase I."
Lesher D.T. , Pommier Y. , Stewart L. , Redinbo M.R.
Proc. Natl. Acad. Sci. U.S.A.99:12102-12107(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.14 ANGSTROMS) OF 202-765 IN COMPLEX WITH DNA
29.

"The mechanism of topoisomerase I poisoning by a camptothecin analog."
Staker B.L. , Hjerrild K. , Feese M.D. , Behnke C.A. , Burgin A.B. Jr. , Stewart L.
Proc. Natl. Acad. Sci. U.S.A.99:15387-15392(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 174-765 IN COMPLEXES WITH DNA AND TOPOTECAN;ACTIVE SITE
30.

"Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex."
Chrencik J.E. , Burgin A.B. , Pommier Y. , Stewart L. , Redinbo M.R.
J. Biol. Chem.278:12461-12466(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 203-764 IN COMPLEX WITH DNA;ACTIVE SITE
31.

"The role of lysine 532 in the catalytic mechanism of human topoisomerase I."
Interthal H. , Quigley P.M. , Hol W.G. , Champoux J.J.
J. Biol. Chem.279:2984-2992(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.13 ANGSTROMS) OF 174-765;MUTAGENESIS OF LYS-532;CATALYTIC ACTIVITY;FUNCTION
32.

"Mechanisms of camptothecin resistance by human topoisomerase I mutations."
Chrencik J.E. , Staker B.L. , Burgin A.B. , Pourquier P. , Pommier Y. , Stewart L. , Redinbo M.R.
J. Mol. Biol.339:773-784(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 201-765 IN COMPLEX WITH DNA AND TOPOTECAN;ACTIVE SITE
33.

"Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex."
Staker B.L. , Feese M.D. , Cushman M. , Pommier Y. , Zembower D. , Stewart L. , Burgin A.B.
J. Med. Chem.48:2336-2345(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 174-765 IN COMPLEXES WITH DNA AND SYNTHETIC INHIBITORS;ACTIVE SITE
34.

"Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis."
Ioanoviciu A. , Antony S. , Pommier Y. , Staker B.L. , Stewart L. , Cushman M.
J. Med. Chem.48:4803-4814(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 174-765 IN COMPLEX WITH DNA AND SYNTHETIC INHIBITORS;CATALYTIC ACTIVITY;FUNCTION;ACTIVE SITE
35.

"Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites."
Tamura H. , Kohchi C. , Yamada R. , Ikeda T. , Koiwai O. , Patterson E. , Keene J.D. , Okada K. , Kjeldsen E. , Nishikawa K.
Nucleic Acids Res.19:69-75(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CPT-RESISTANT LEUKEMIA GLY-533
36.

"Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line."
Kubota N. , Kanzawa F. , Nishio K. , Takeda Y. , Ohmori T. , Fujiwara Y. , Terashima Y. , Saijo N.
Biochem. Biophys. Res. Commun.188:571-577(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CPT-RESISTANT LUNG CANCER ALA-729
37.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] BREAST CANCER ARG-326

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