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Index > Protein center > TOP2A(Gene name) > Human
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  • TOP2A (Gene name),
  • DNA topoisomerase 2-alpha (Protein name ),  TOP2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TOP2A(TOP2);
    Protein name:
    DNA topoisomerase 2-alpha;
    Alternative:
    DNA topoisomerase II, alpha isozyme;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with COPS5.
    Function:
    Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
    Subcellular Location:
    Cytoplasm Nucleus nucleoplasm Generally located in the nucleoplasm.
    Protein Attributes:
    Sequence length:
    1531
    Sequence:
    50:
    MEVSPLQPVN | ENMQVNKIKK | NEDAKKRLSV | ERIYQKKTQL | EHILLRPDTY | 
    100:
    IGSVELVTQQ | MWVYDEDVGI | NYREVTFVPG | LYKIFDEILV | NAADNKQRDP | 
    150:
    KMSCIRVTID | PENNLISIWN | NGKGIPVVEH | KVEKMYVPAL | IFGQLLTSSN | 
    200:
    YDDDEKKVTG | GRNGYGAKLC | NIFSTKFTVE | TASREYKKMF | KQTWMDNMGR | 
    250:
    AGEMELKPFN | GEDYTCITFQ | PDLSKFKMQS | LDKDIVALMV | RRAYDIAGST | 
    300:
    KDVKVFLNGN | KLPVKGFRSY | VDMYLKDKLD | ETGNSLKVIH | EQVNHRWEVC | 
    350:
    LTMSEKGFQQ | ISFVNSIATS | KGGRHVDYVA | DQIVTKLVDV | VKKKNKGGVA | 
    400:
    VKAHQVKNHM | WIFVNALIEN | PTFDSQTKEN | MTLQPKSFGS | TCQLSEKFIK | 
    450:
    AAIGCGIVES | ILNWVKFKAQ | VQLNKKCSAV | KHNRIKGIPK | LDDANDAGGR | 
    500:
    NSTECTLILT | EGDSAKTLAV | SGLGVVGRDK | YGVFPLRGKI | LNVREASHKQ | 
    550:
    IMENAEINNI | IKIVGLQYKK | NYEDEDSLKT | LRYGKIMIMT | DQDQDGSHIK | 
    600:
    GLLINFIHHN | WPSLLRHRFL | EEFITPIVKV | SKNKQEMAFY | SLPEFEEWKS | 
    650:
    STPNHKKWKV | KYYKGLGTST | SKEAKEYFAD | MKRHRIQFKY | SGPEDDAAIS | 
    700:
    LAFSKKQIDD | RKEWLTNFME | DRRQRKLLGL | PEDYLYGQTT | TYLTYNDFIN | 
    750:
    KELILFSNSD | NERSIPSMVD | GLKPGQRKVL | FTCFKRNDKR | EVKVAQLAGS | 
    800:
    VAEMSSYHHG | EMSLMMTIIN | LAQNFVGSNN | LNLLQPIGQF | GTRLHGGKDS | 
    850:
    ASPRYIFTML | SSLARLLFPP | KDDHTLKFLY | DDNQRVEPEW | YIPIIPMVLI | 
    900:
    NGAEGIGTGW | SCKIPNFDVR | EIVNNIRRLM | DGEEPLPMLP | SYKNFKGTIE | 
    950:
    ELAPNQYVIS | GEVAILNSTT | IEISELPVRT | WTQTYKEQVL | EPMLNGTEKT | 
    1000:
    PPLITDYREY | HTDTTVKFVV | KMTEEKLAEA | ERVGLHKVFK | LQTSLTCNSM | 
    1050:
    VLFDHVGCLK | KYDTVLDILR | DFFELRLKYY | GLRKEWLLGM | LGAESAKLNN | 
    1100:
    QARFILEKID | GKIIIENKPK | KELIKVLIQR | GYDSDPVKAW | KEAQQKVPDE | 
    1150:
    EENEESDNEK | ETEKSDSVTD | SGPTFNYLLD | MPLWYLTKEK | KDELCRLRNE | 
    1200:
    KEQELDTLKR | KSPSDLWKED | LATFIEELEA | VEAKEKQDEQ | VGLPGKGGKA | 
    1250:
    KGKKTQMAEV | LPSPRGQRVI | PRITIEMKAE | AEKKNKKKIK | NENTEGSPQE | 
    1300:
    DGVELEGLKQ | RLEKKQKREP | GTKTKKQTTL | AFKPIKKGKK | RNPWSDSESD | 
    1350:
    RSSDESNFDV | PPRETEPRRA | ATKTKFTMDL | DSDEDFSDFD | EKTDDEDFVP | 
    1400:
    SDASPPKTKT | SPKLSNKELK | PQKSVVSDLE | ADDVKGSVPL | SSSPPATHFP | 
    1450:
    DETEITNPVP | KKNVTVKKTA | AKSQSSTSTT | GAKKRAAPKG | TKRDPALNSG | 
    1500:
    VSQKPDPAKT | KNRRKRKPST | SDDSDSNFEK | IVSKAVTSKK | SKGESDDFHM | 
    1531:
    DFDSAVAPRA | KSVRAKKPIK | YLEESDEDDL | F
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    E8718h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human DNA topoisomerase 2-alpha
    MSDS:
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    ELISA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    E8718m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    E8718r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    E8718p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    U8718r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA topoisomerase 2-alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    U8718h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    U8718m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA topoisomerase 2-alpha
    Cat.:
    U8718p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human DNA topoisomerase 2-alpha
    Cat.:
    P8718Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA topoisomerase 2-alpha
    Polyclonal Antibody for Human DNA topoisomerase 2-alpha
    Polyclonal Antibody for Human DNA topoisomerase 2-alpha
    Cat.:
    P8718Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA topoisomerase 2-alpha
    Monoclonal Antibody for Human DNA topoisomerase 2-alpha
    Monoclonal Antibody for Human DNA topoisomerase 2-alpha
    Monoclonal Antibody for Human DNA topoisomerase 2-alpha
    Monoclonal Antibody for Human DNA topoisomerase 2-alpha
    Monoclonal Antibody for Human DNA topoisomerase 2-alpha
    Protein for Human DNA topoisomerase 2-alpha
    Protein for Human DNA topoisomerase 2-alpha
    Protein for Human DNA topoisomerase 2-alpha
    Protein for Human DNA topoisomerase 2-alpha
    Protein for Human DNA topoisomerase 2-alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22."
      Tsai-Pflugfelder M. , Liu L.F. , Liu A.A. , Tewey K.M. , Whang-Peng J. , Knutsen T. , Huebner K. , Croce C.M. , Wang J.C.
      Proc. Natl. Acad. Sci. U.S.A.85:7177-7181(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast."
      Wasserman R.A. , Austin C.A. , Fisher L.M. , Wang J.C.
      Cancer Res.53:3591-3596(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 109-114
    3. 3.
      "Structural organization of the human TOP2A and TOP2B genes."
      Lang A.J. , Mirski S.E. , Cummings H.J. , Yu Q. , Gerlach J.H. , Cole S.P.
      Gene221:255-266(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    4. 4.
      "Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication."
      Sng J.H. , Heaton V.J. , Bell M. , Mani P. , Austin C.A. , Fisher L.M.
      Biochim. Biophys. Acta1444:395-406(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 8.
      "Two differentially spliced forms of topoisomerase II alpha and beta mRNAs are conserved between birds and humans."
      Petruti-Mot A.S. , Earnshaw W.C.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-500 (ISOFORMS 2; 3 AND 4)
    8. 9.
      Neri S. , Govoni M. , Perrotta L. , Pozzi S. , Pession A.
      Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21 AND 48-72
    9. 10.
      Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-17; 74-96; 124-131; 169-184; 243-251; 277-287; 325-336; 387-397; 467-478; 481-487; 500-519; 569-579; 702-713; 805-815; 828-835; 864-877; 937-958; 1021-1026 AND 1185-1196;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    10. 11.
      Bienvenut W.V. , Waridel P. , Quadroni M.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 135-157; 228-241; 307-321; 325-336; 387-397; 401-416; 467-478; 536-550; 569-579; 640-655; 702-713; 805-815; 1011-1020; 1097-1114; 1169-1184; 1239-1259 AND 1374-1411;PHOSPHORYLATION AT SER-1106;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Cervix carcinoma.
    11. 12.
      "Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469."
      Escargueil A.E. , Plisov S.Y. , Filhol O. , Cochet C. , Larsen A.K.
      J. Biol. Chem.275:34710-34718(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1469;MUTAGENESIS OF SER-1469
    12. 13.
      "Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta."
      Mirski S.E. , Bielawski J.C. , Cole S.P.
      Biochem. Biophys. Res. Commun.306:905-911(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEAR EXPORT SIGNAL
    13. 14.
      "Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5."
      Yun J. , Tomida A. , Andoh T. , Tsuruo T.
      J. Biol. Chem.279:31296-31303(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
    14. 15.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-1106; SER-1213; SER-1247; SER-1332; SER-1337; THR-1343; SER-1351; SER-1354; SER-1374; SER-1377 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 16.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213; SER-1374; SER-1377 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 17.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 18.
      "Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1."
      Iida M. , Matsuda M. , Komatani H.
      Biochem. J.411:27-32(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-1343
    18. 19.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1504;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 20.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-1213; SER-1247; SER-1332; SER-1337 AND SER-1377;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 21.
      "The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation."
      Williamson E.A. , Rasila K.K. , Corwin L.K. , Wray J. , Beck B.D. , Severns V. , Mobarak C. , Lee S.H. , Nickoloff J.A. , Hromas R.
      Nucleic Acids Res.36:5822-5831(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SETMAR
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1213; SER-1332; SER-1337; THR-1343; SER-1351; SER-1392; SER-1393; SER-1449; SER-1469; THR-1470; SER-1471; SER-1474 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 23.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 24.
      "Use of divalent metal ions in the DNA cleavage reaction of human type II topoisomerases."
      Deweese J.E. , Burch A.M. , Burgin A.B. , Osheroff N.
      Biochemistry48:1862-1869(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;COFACTOR
    24. 25.
      "Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha."
      Deweese J.E. , Guengerich F.P. , Burgin A.B. , Osheroff N.
      Biochemistry48:8940-8947(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-461; ASP-541; ASP-543 AND ASP-545;PUTATIVE METAL-BINDING SITES;CATALYTIC ACTIVITY;COFACTOR
    25. 26.
      "Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity."
      Grozav A.G. , Chikamori K. , Kozuki T. , Grabowski D.R. , Bukowski R.M. , Willard B. , Kinter M. , Andersen A.H. , Ganapathi R. , Ganapathi M.K.
      Nucleic Acids Res.37:382-392(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1106 BY CSNK1D/CK1
    26. 27.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247; SER-1374; SER-1387; SER-1393; SER-1504 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    27. 28.
      "Metnase promotes restart and repair of stalled and collapsed replication forks."
      De Haro L.P. , Wray J. , Williamson E.A. , Durant S.T. , Corwin L. , Gentry A.C. , Osheroff N. , Lee S.H. , Hromas R. , Nickoloff J.A.
      Nucleic Acids Res.38:5681-5691(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SETMAR
    28. 29.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; THR-282; SER-1106; THR-1205; SER-1213; SER-1247; SER-1332; SER-1337; THR-1343; SER-1351; SER-1354; SER-1374; SER-1377; SER-1471; SER-1474; SER-1495; SER-1504 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    29. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    30. 31.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-1106; SER-1213; SER-1247; SER-1295; SER-1297; SER-1299; SER-1302; SER-1332; SER-1337; THR-1343; SER-1351; SER-1354; SER-1374; SER-1377; SER-1469; THR-1470; SER-1471; SER-1474; SER-1476 AND SER-1525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    31. 32.
      "Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity."
      Schmidt B.H. , Osheroff N. , Berger J.M.
      Nat. Struct. Mol. Biol.19:1147-1154(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 342-LYS--LYS-344
    32. 33.
      "RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression."
      Ramamoorthy M. , Tadokoro T. , Rybanska I. , Ghosh A.K. , Wersto R. , May A. , Kulikowicz T. , Sykora P. , Croteau D.L. , Bohr V.A.
      Nucleic Acids Res.40:1621-1635(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RECQL5
    33. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    34. 35.
      "DNA cleavage and opening reactions of human topoisomerase IIalpha are regulated via Mg2+-mediated dynamic bending of gate-DNA."
      Lee S. , Jung S.R. , Heo K. , Byl J.A. , Deweese J.E. , Osheroff N. , Hohng S.
      Proc. Natl. Acad. Sci. U.S.A.109:2925-2930(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLU-461; ASP-541 AND ASP-543;COFACTOR
    35. 36.
      "Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase."
      Wei H. , Ruthenburg A.J. , Bechis S.K. , Verdine G.L.
      J. Biol. Chem.280:37041-37047(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 29-428 IN COMPLEX WITH ADP;X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 29-428 IN COMPLEX WITH AMPPNP
    36. 37.
      "The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage."
      Wendorff T.J. , Schmidt B.H. , Heslop P. , Austin C.A. , Berger J.M.
      J. Mol. Biol.424:109-124(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 431-1193 IN COMPLEX WITH DNA AND MAGNESIUM ION;SUBUNIT;COFACTOR
    37. 38.
      "Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II."
      Hinds M. , Deisseroth K. , Mayes J. , Altschuler E. , Jansen R. , Ledley F.D. , Zwelling L.A.
      Cancer Res.51:4729-4731(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AMSACRINE-RESISTANT LYS-487
    38. 39.
      "Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide."
      Bugg B.Y. , Danks M.K. , Beck W.T. , Suttle D.P.
      Proc. Natl. Acad. Sci. U.S.A.88:7654-7658(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TENIPOSIDE-RESISTANT GLN-450
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