Protein name:
Tissue-type plasminogen activator (t-PA;t-plasminogen activator;tPA) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.
Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.
Subcellular Location:
Secreted
extracellular space
Protein Attributes:
50:
MDAMKRGLCC | VLLLCGAVFV | SPSQEIHARF | RRGARSYQVI | CRDEKTQMIY |
100:
QQHQSWLRPV | LRSNRVEYCW | CNSGRAQCHS | VPVKSCSEPR | CFNGGTCQQA |
150:
LYFSDFVCQC | PEGFAGKCCE | IDTRATCYED | QGISYRGTWS | TAESGAECTN |
200:
WNSSALAQKP | YSGRRPDAIR | LGLGNHNYCR | NPDRDSKPWC | YVFKAGKYSS |
250:
EFCSTPACSE | GNSDCYFGNG | SAYRGTHSLT | ESGASCLPWN | SMILIGKVYT |
300:
AQNPSAQALG | LGKHNYCRNP | DGDAKPWCHV | LKNRRLTWEY | CDVPSCSTCG |
350:
LRQYSQPQFR | IKGGLFADIA | SHPWQAAIFA | KHRRSPGERF | LCGGILISSC |
400:
WILSAAHCFQ | ERFPPHHLTV | ILGRTYRVVP | GEEEQKFEVE | KYIVHKEFDD |
450:
DTYDNDIALL | QLKSDSSRCA | QESSVVRTVC | LPPADLQLPD | WTECELSGYG |
500:
KHEALSPFYS | ERLKEAHVRL | YPSSRCTSQH | LLNRTVTDNM | LCAGDTRSGG |
550:
PQANLHDACQ | GDSGGPLVCL | NDGRMTLVGI | ISWGLGCGQK | DVPGVYTKVT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Rat
Mouse
Bovine
Polyclonal Antibody for Human t-PA
Polyclonal Antibody for Human t-PA
Polyclonal Antibody for Human t-PA
Polyclonal Antibody for Human t-PA
Polyclonal Antibody for Human t-PA
Monoclonal Antibody for Human t-PA
Monoclonal Antibody for Human t-PA
Monoclonal Antibody for Human t-PA
Monoclonal Antibody for Human t-PA
Monoclonal Antibody for Human t-PA
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Zeng L. · Liu J. · Wang Y. · Wang L. · Weng S. · Chen S. · Yang G.-Y.
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Melanoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Fetal lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Brain .
tissue :
Placenta .
tissue :
Skin .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 31-562
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 33-52 AND 311-330
tissue :
Melanoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 36-562
tissue :
Melanoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 251-358
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;SIGNAL SEQUENCE CLEAVAGE SITE
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE OF CARBOHYDRATES
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-96
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS IN KRINGLE 2 DOMAIN
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LRP1B
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF KRINGLE 2
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF KRINGLE 2
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF KRINGLE 2
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF KRINGLE 2
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 38-85
32.
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Cited for : STRUCTURE BY NMR OF 36-126
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF CATALYTIC DOMAIN
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Cited for : X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF CATALYTIC DOMAIN