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Index > Protein center > Plat(Gene name) > Mouse
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  • Plat (Gene name),
  • Tissue-type plasminogen activator (Protein name ),  TPA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Plat;
    Protein name:
    Tissue-type plasminogen activator(t-PA;t-plasminogen activator;tPA);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation.
    Function:
    Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    559
    Sequence:
    50:
    MKRELLCVLL | LCGLAFPLPD | QGIHGRFRRG | ARSYRATCRD | EPTQTTYQQH | 
    100:
    QSWLRPMLRS | SRVEYCRCNS | GLVQCHSVPV | RSCSEPRCFN | GGTCQQALYF | 
    150:
    SDFVCQCPDG | FVGKRCDIDT | RATCFEEQGI | TYRGTWSTAE | SGAECINWNS | 
    200:
    SVLSLKPYNA | RRPNAIKLGL | GNHNYCRNPD | RDLKPWCYVF | KAGKYTTEFC | 
    250:
    STPACPKGKS | EDCYVGKGVT | YRGTHSLTTS | QASCLPWNSI | VLMGKSYTAW | 
    300:
    RTNSQALGLG | RHNYCRNPDG | DARPWCHVMK | DRKLTWEYCD | MSPCSTCGLR | 
    350:
    QYKRPQFRIK | GGLYTDITSH | PWQAAIFVKN | KRSPGERFLC | GGVLISSCWV | 
    400:
    LSAAHCFLER | FPPNHLKVVL | GRTYRVVPGE | EEQTFEIEKY | IVHEEFDDDT | 
    450:
    YDNDIALLQL | RSQSKQCAQE | SSSVGTACLP | DPNLQLPDWT | ECELSGYGKH | 
    500:
    EASSPFFSDR | LKEAHVRLYP | SSRCTSQHLF | NKTVTNNMLC | AGDTRSGGNQ | 
    550:
    DLHDACQGDS | GGPLVCMINK | QMTLTGIISW | GLGCGQKDVP | GVYTKVTNYL | 
    559:
    DWIHDNMKQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse t-PA
    Cat.:
    E0525p
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    Packing:
    96T
    ELISA Kit for Mouse t-PA
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    ELISA Kit for Mouse t-PA
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    E0525r
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    ELISA Kit for Mouse t-PA
    Cat.:
    E0525m
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    ELISA Kit for Mouse t-PA
    Cat.:
    E0525b
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    Packing:
    96T
    CLIA Kit for Mouse t-PA
    Cat.:
    U0525m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse t-PA
    Cat.:
    U0525b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse t-PA
    Cat.:
    U0525p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse t-PA
    Cat.:
    U0525h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse t-PA
    Cat.:
    U0525r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse t-PA
    Cat.:
    P0525Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse t-PA
    Polyclonal Antibody for Mouse t-PA
    Polyclonal Antibody for Mouse t-PA
    Cat.:
    P0525Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse t-PA
    Cat.:
    P0525Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse t-PA
    Monoclonal Antibody for Mouse t-PA
    Monoclonal Antibody for Mouse t-PA
    Monoclonal Antibody for Mouse t-PA
    Monoclonal Antibody for Mouse t-PA
    Protein for Mouse t-PA
    Protein for Mouse t-PA
    Protein for Mouse t-PA
    Protein for Mouse t-PA
    Protein for Mouse t-PA

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    References
    1. 1.
      "Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation."
      Rickles R.J. , Darrow A.L. , Strickland S.
      J. Biol. Chem.263:1563-1569(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      strain: NMRI.
      tissue: Mammary gland.
      tissue: Mammary tumor.
    4. 4.
      "Characterization of the murine plasma fibrinolytic system."
      Lijnen H.R. , van Hoef B. , Beelen V. , Collen D.
      Eur. J. Biochem.224:863-871(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-40 AND 309-316
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