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Index > Protein center > PLAT(Gene name) > Pig
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  • PLAT (Gene name),
  • Tissue-type plasminogen activator (Protein name ),  TPA_PIG from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PLAT;
    Protein name:
    Tissue-type plasminogen activator(t-PA;t-plasminogen activator;tPA);
    Alternative:

    Organism:
    Pig (Sus scrofa). 
    General Annotation
    Sub Unit:
    Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation.
    Function:
    Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    562
    Sequence:
    50:
    MYALKRELWC | VLLLCGAICT | SPSQETHRRL | RRGVRSYRVT | CRDEKTQMIY | 
    100:
    QQHQSWLRPL | LRGNRVEHCW | CNDGQTQCHS | VPVKSCSEPR | CFNGGTCLQA | 
    150:
    IYFSDFVCQC | PVGFIGRQCE | IDARATCYED | QGITYRGTWS | TTESGAECVN | 
    200:
    WNTSGLASMP | YNGRRPDAVK | LGLGNHNYCR | NPDKDSKPWC | YIFKAEKYSP | 
    250:
    DFCSTPACTK | EKEECYTGKG | LDYRGTRSLT | MSGAFCLPWN | SLVLMGKIYT | 
    300:
    AWNSNAQTLG | LGKHNYCRNP | DGDTQPWCHV | LKDHKLTWEY | CDLPQCVTCG | 
    350:
    LRQYKEPQFR | IKGGLYADIT | SHPWQAAIFV | KNRRSPGERF | LCGGILISSC | 
    400:
    WVLSAAHCFQ | ERFPPHHVRV | VLGRTYRLVP | GEEEQAFEVE | KYIVHKEFDD | 
    450:
    DTYDNDIALL | QLKSDSLTCA | QESDAVRTVC | LPEANLQLPD | WTECELSGYG | 
    500:
    KHEASSPFYS | ERLKEAHVRL | YPSSRCTSKH | LFNKTITNNM | LCAGDTRSGG | 
    550:
    DNANLHDACQ | GDSGGPLVCM | KGNHMTLVGV | ISWGLGCGQK | DVPGVYTKVT | 
    562:
    NYLNWIRDNT | RP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Pig t-PA
    Cat.:
    E0525p
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Pig t-PA
    Cat.:
    E0525h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Pig t-PA
    Cat.:
    E0525r
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Pig t-PA
    Cat.:
    E0525m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Pig t-PA
    Cat.:
    E0525b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig t-PA
    Cat.:
    U0525m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig t-PA
    Cat.:
    U0525b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig t-PA
    Cat.:
    U0525p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig t-PA
    Cat.:
    U0525h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig t-PA
    Cat.:
    U0525r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Pig t-PA
    Cat.:
    P0525Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig t-PA
    Polyclonal Antibody for Pig t-PA
    Polyclonal Antibody for Pig t-PA
    Cat.:
    P0525Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig t-PA
    Cat.:
    P0525Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Pig t-PA
    Monoclonal Antibody for Pig t-PA
    Monoclonal Antibody for Pig t-PA
    Monoclonal Antibody for Pig t-PA
    Monoclonal Antibody for Pig t-PA
    Protein for Pig t-PA
    Protein for Pig t-PA
    Protein for Pig t-PA
    Protein for Pig t-PA
    Protein for Pig t-PA

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    References
    1. 1.
      "T-plasminogen activator in tooth tissues."
      Ding Y. , Xue J. , Bartlett J.D.
      Submitted (2001-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Enamel organ.
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