Protein name:
Tissue-type plasminogen activator (t-PA;t-plasminogen activator;tPA) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation.
Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
Subcellular Location:
Secreted
extracellular space
Protein Attributes:
50:
MKGELLCVLL | LCGVAFTLPD | QGIHRRFRRG | ARSYRATCRD | EQTQTTYQQH |
100:
QSWLRPMLRG | NRVEYCRCNS | GLAQCHSVPV | RSCSEPRCFN | GGTCQQALYF |
150:
SDFVCQCPDG | FVGKRCDIDT | RATCFEGQGI | TYRGTWSTAE | NGAECINWNS |
200:
SALSQKPYSA | RRPNAIKLGL | GNHNYCRNPD | RDVKPWCYVF | KAGKYTTEFC |
250:
STPACPKGPT | EDCYVGKGVT | YRGTHSFTTS | KASCLPWNSM | ILIGKTYTAW |
300:
RANSQALGLG | RHNYCRNPDG | DAKPWCHVMK | DRKLTWEYCD | MSPCSTCGLR |
350:
QYKQPQFRIK | GGLFTDITSH | PWQAAIFVKN | KRSPGERFLC | GGVLISSCWV |
400:
LSAAHCFVER | FPPHHLKVVL | GRTYRVVPGE | EEQTFEIEKY | IVHKEFDDDT |
450:
YDNDIALLQL | RSDSSQCAQE | SSSVGTACLP | DPDVQLPDWT | ECELSGYGKH |
500:
EASSPFFSDR | LKEAHVRLYP | SSRCTSQHLF | NKTITSNMLC | AGDTRTGGNQ |
550:
DVHDACQGDS | GGPLVCMIDK | RMTLLGIISW | GLGCGQKDVP | GIYTKVTNYL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Rat
Mouse
Bovine
Polyclonal Antibody for Rat t-PA
Polyclonal Antibody for Rat t-PA
Polyclonal Antibody for Rat t-PA
Polyclonal Antibody for Rat t-PA
Polyclonal Antibody for Rat t-PA
Monoclonal Antibody for Rat t-PA
Monoclonal Antibody for Rat t-PA
Monoclonal Antibody for Rat t-PA
Monoclonal Antibody for Rat t-PA
Monoclonal Antibody for Rat t-PA
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Pituitary .