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Index > Protein center > TPH2(Gene name) > Human
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  • TPH2 (Gene name),
  • Tryptophan 5-hydroxylase 2 (Protein name ),  TPH2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TPH2(NTPH);
    Protein name:
    Tryptophan 5-hydroxylase 2;
    Alternative:
    Tryptophan 5-monooxygenase 2;Neuronal tryptophan hydroxylase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    N/A
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    490
    Sequence:
    50:
    MQPAMMMFSS | KYWARRGFSL | DSAVPEEHQL | LGSSTLNKPN | SGKNDDKGNK | 
    100:
    GSSKREAATE | SGKTAVVFSL | KNEVGGLVKA | LRLFQEKRVN | MVHIESRKSR | 
    150:
    RRSSEVEIFV | DCECGKTEFN | ELIQLLKFQT | TIVTLNPPEN | IWTEEEELED | 
    200:
    VPWFPRKISE | LDKCSHRVLM | YGSELDADHP | GFKDNVYRQR | RKYFVDVAMG | 
    250:
    YKYGQPIPRV | EYTEEETKTW | GVVFRELSKL | YPTHACREYL | KNFPLLTKYC | 
    300:
    GYREDNVPQL | EDVSMFLKER | SGFTVRPVAG | YLSPRDFLAG | LAYRVFHCTQ | 
    350:
    YIRHGSDPLY | TPEPDTCHEL | LGHVPLLADP | KFAQFSQEIG | LASLGASDED | 
    400:
    VQKLATCYFF | TIEFGLCKQE | GQLRAYGAGL | LSSIGELKHA | LSDKACVKAF | 
    450:
    DPKTTCLQEC | LITTFQEAYF | VSESFEEAKE | KMRDFAKSIT | RPFSVYFNPY | 
    490:
    TQSIEILKDT | RSIENVVQDL | RSDLNTVCDA | LNKMNQYLGI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    E2229h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    E2229r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    E2229m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    U2229m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    U2229r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tryptophan 5-hydroxylase 2
    Cat.:
    U2229h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Cat.:
    P2229Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Cat.:
    P2229Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Cat.:
    P2229Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Monoclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Monoclonal Antibody for Human Tryptophan 5-hydroxylase 2
    Protein for Human Tryptophan 5-hydroxylase 2
    Protein for Human Tryptophan 5-hydroxylase 2
    Protein for Human Tryptophan 5-hydroxylase 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
      Walther D.J. , Peter J.-U. , Bashammakh S. , Hortnagl H. , Voits M. , Fink H. , Bader M.
      Science299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    2. 2.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
    4. 4.
      "Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder."
      Cichon S. , Winge I. , Mattheisen M. , Georgi A. , Karpushova A. , Freudenberg J. , Freudenberg-Hua Y. , Babadjanova G. , Van Den Bogaert A. , Abramova L.I. , Kapiletti S. , Knappskog P.M. , McKinney J. , Maier W. , Jamra R.A. , Schulze T.G. , Schumacher J. , Propping P. , more...
      Hum. Mol. Genet.17:87-97(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;VARIANT SER-206;CHARACTERIZATION OF VARIANTS SER-206 AND HIS-441
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS A AND B);RNA EDITING OF POSITIONS 433; 441 AND 468
      tissue: Brain.
    6. 6.
      "Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression."
      Zhang X. , Gainetdinov R.R. , Beaulieu J.-M. , Sotnikova T.D. , Burch L.H. , Williams R.B. , Schwartz D.A. , Krishnan K.R.R. , Caron M.G.
      Neuron45:11-16(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-441;CHARACTERIZATION OF VARIANT HIS-441
    7. 7.
      "A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder."
      McKinney J. , Johansson S. , Halmoy A. , Dramsdahl M. , Winge I. , Knappskog P.M. , Haavik J.
      Mol. Psychiatry13:365-367(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADHD7 TRP-303
    8. 8.
      "Functional properties of missense variants of human tryptophan hydroxylase 2."
      McKinney J.A. , Turel B. , Winge I. , Knappskog P.M. , Haavik J.
      Hum. Mutat.30:787-794(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS VAL-36; PRO-36; TYR-41; CYS-55; SER-206; TRP-303; VAL-328; HIS-441 AND GLU-479
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