TPMT ELISA Kit for Human(Homo sapiens) | EIAab.comTPMT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TPMT(Gene name) > Human

TPMT (Gene name),

Thiopurine S-methyltransferase (Protein name ), TPMT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TPMT;

Protein name:

Thiopurine S-methyltransferase;

Alternative:

Thiopurine methyltransferase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

245

Sequence:

50:

100:

150:

200:

245:

HAEIERLFGK | ICNIRCLEKV | DAFEERHKSW | GIDCLFEKLY | LLTEK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P51580

UniGene:

Hs.444319

String:

P51580

Pfam:

PF05724

KEGG:

hsa:7172

MIM:

187680

Uniprot:

P51580

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ELISA Kit for Human Thiopurine S-methyltransferase

Cat.:

E10435h

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Packing:

96T

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ELISA Kit for Human Thiopurine S-methyltransferase

MSDS:

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ELISA Kit for Human Thiopurine S-methyltransferase

MSDS:

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ELISA Kit for Human Thiopurine S-methyltransferase

Cat.:

E10435m

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Packing:

96T

ELISA Kit for Human Thiopurine S-methyltransferase

Cat.:

E10435r

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Packing:

96T

ELISA Kit for Human Thiopurine S-methyltransferase

MSDS:

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CLIA Kit for Human Thiopurine S-methyltransferase

Cat.:

U10435m

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Packing:

96T

CLIA Kit for Human Thiopurine S-methyltransferase

MSDS:

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CLIA Kit for Human Thiopurine S-methyltransferase

MSDS:

Please sign in first.

CLIA Kit for Human Thiopurine S-methyltransferase

MSDS:

Please sign in first.

CLIA Kit for Human Thiopurine S-methyltransferase

Cat.:

U10435h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Thiopurine S-methyltransferase

Cat.:

U10435r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Thiopurine S-methyltransferase

Cat.:

P10435Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Thiopurine S-methyltransferase

Monoclonal Antibody for Human Thiopurine S-methyltransferase

Protein for Human Thiopurine S-methyltransferase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA."
Honchel R. , Aksoy I.A. , Szumlanski C. , Wood T.C. , Otterness D.M. , Wieben E.D. , Weinshilboum R.M.
Mol. Pharmacol.43:878-887(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Kidney.
2.

"Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1."
Lee D. , Szumlanski C.L. , Houtman J. , Honchel R. , Rojas K. , Overhauser J. , Weiben E.D. , Weinshilboum R.M.
Drug Metab. Dispos.23:398-405(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism."
Szumlanski C. , Otterness D. , Her C. , Lee D. , Brandriff B. , Kelsell D. , Spurr N. , Lennard L. , Wieben E. , Weinshilboum R.M.
DNA Cell Biol.15:17-30(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
4.

"Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library."
Krynetski E.Y. , Fessing M.Y. , Yates C.R. , Sun D. , Schuetz J.D. , Evans W.E.
Pharm. Res.14:1672-1678(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms."
Otterness D. , Szumlanski C. , Lennard L. , Klemetsdal B. , Aarbakke J. , Park-Hah J.O. , Iven H. , Schmiegelow K. , Branum E. , O'Brien J. , Weinshilboum R.M.
Clin. Pharmacol. Ther.62:60-73(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-49 AND PHE-180;VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
6.

"Genomic structure of thiopurine S-methyltransferase gene."
Nakamura Y.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Bone marrow.
9.

"Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis."
Spire-Vayron de la Moureyre C. , Debuysere H. , Sabbagh N. , Marez D. , Vinner E. , Chevalier E.D. , Lo-Guidice J.-M. , Broly F.
Hum. Mutat.12:177-185(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-245;VARIANT TPMT DEFICIENCY GLN-227
10.

"Structural basis of substrate recognition in thiopurine s-methyltransferase."
Peng Y. , Feng Q. , Wilk D. , Adjei A.A. , Salavaggione O.E. , Weinshilboum R.M. , Yee V.C.
Biochemistry47:6216-6225(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ARG-152
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
14.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-58;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Structural basis of allele variation of human thiopurine-S-methyltransferase."
Wu H. , Horton J.R. , Battaile K. , Allali-Hassani A. , Martin F. , Zeng H. , Loppnau P. , Vedadi M. , Bochkarev A. , Plotnikov A.N. , Cheng X.
Proteins67:198-208(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 16-245 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE;SUBUNIT;CHARACTERIZATION OF VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
17.

"A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase."
Krynetski E.Y. , Schuetz J.D. , Galpin A.J. , Pui C.-H. , Relling M.V. , Evans W.E.
Proc. Natl. Acad. Sci. U.S.A.92:949-953(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TPMT DEFICIENCY PRO-80
18.

"Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians."
Tai H.-L. , Krynetski E.Y. , Yates C.R. , Loennechen T. , Fessing M.Y. , Krynetskaia N.F. , Evans W.E.
Am. J. Hum. Genet.58:694-702(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
19.

"Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis."
Leipold G. , Schuetz E. , Haas J.P. , Oellerich M.
Arthritis Rheum.40:1896-1898(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
20.

"Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity."
Tai H.-L. , Krynetski E.Y. , Schuetz E.G. , Yanishevski Y. , Evans W.E.
Proc. Natl. Acad. Sci. U.S.A.94:6444-6449(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS TPMT DEFICIENCY PRO-80 AND THR-154;MECHANISM FOR THE GENETIC POLYMORPHISM OF TPMT ACTIVITY
21.

"Thiopurine methyltransferase alleles in British and Ghanaian populations."
Ameyaw M.-M. , Collie-Duguid E.S.R. , Powrie R.H. , Ofori-Adjei D. , McLeod H.L.
Hum. Mol. Genet.8:367-370(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154 AND CYS-240
22.

"Polymorphism of the thiopurine S-methyltransferase gene in African-Americans."
Hon Y.Y. , Fessing M.Y. , Pui C.-H. , Relling M.V. , Krynetski E.Y. , Evans W.E.
Hum. Mol. Genet.8:371-376(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TPMT DEFICIENCY HIS-215
23.

"The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations."
Collie-Duguid E.S.R. , Pritchard S.C. , Powrie R.H. , Sludden J. , Collier D.A. , Li T. , McLeod H.L.
Pharmacogenetics9:37-42(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154 AND CYS-240;FREQUENCY AND DISTRIBUTION OF ALLELES
24.

"Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population."
Hiratsuka M. , Inoue T. , Omori F. , Agatsuma Y. , Mizugaki M.
Mutat. Res.448:91-95(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154 AND CYS-240;FREQUENCY AND DISTRIBUTION OF ALLELES
25.

"Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics."
Salavaggione O.E. , Wang L. , Wiepert M. , Yee V.C. , Weinshilboum R.M.
Pharmacogenet. Genomics15:801-815(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154; HIS-215; GLN-227 AND CYS-240;VARIANTS SER-49 AND PHE-180;CHARACTERIZATION OF VARIANTS TPMT DEFICIENCY PRO-80; THR-154; HIS-215; GLN-227 AND CYS-240;CHARACTERIZATION OF VARIANTS SER-49 AND PHE-180
26.

"Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C)."
Kurzawski M. , Dziewanowski K. , Ciechanowski K. , Drozdzik M.
Transpl. Int.18:623-625(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY THR-154 AND CYS-240
27.

"Molecular analysis of thiopurine S-methyltransferase alleles in Taiwan aborigines and Taiwanese."
Lu H.-F. , Shih M.-C. , Chang Y.-S. , Chang J.-Y. , Ko Y.-C. , Chang S.-J. , Chang J.-G.
J. Clin. Pharm. Ther.31:93-98(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154 AND CYS-240;FREQUENCY AND DISTRIBUTION OF ALLELES
28.

"Frequency of the thiopurine S-methyltransferase alleles in the ancient genetic population isolate of Sardinia."
Rossino R. , Vincis C. , Alves S. , Prata M.J. , Macis M.D. , Nucaro A.L. , Schirru E. , Congia M.
J. Clin. Pharm. Ther.31:283-287(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TPMT DEFICIENCY PRO-80; THR-154 AND CYS-240;FREQUENCY AND DISTRIBUTION OF ALLELES

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