Protein name:
Thrombopoietin ;
Alternative:
Megakaryocyte colony-stimulating factor ;C-mpl ligand (ML) ;Myeloproliferative leukemia virus oncogene ligand ;Megakaryocyte growth and development factor (MGDF) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular Location:
Secreted
Protein Attributes:
50:
MELTELLLVV | MLLLTARLTL | SSPAPPACDL | RVLSKLLRDS | HVLHSRLSQC |
100:
PEVHPLPTPV | LLPAVDFSLG | EWKTQMEETK | AQDILGAVTL | LLEGVMAARG |
150:
QLGPTCLSSL | LGQLSGQVRL | LLGALQSLLG | TQLPPQGRTT | AHKDPNAIFL |
200:
SFQHLLRGKV | RFLMLVGGST | LCVRRAPPTT | AVPSRTSLVL | TLNELPNRTS |
250:
GLLETNFTAS | ARTTGSGLLK | WQQGFRAKIP | GLLNQTSRSL | DQIPGYLNRI |
300:
HELLNGTRGL | FPGPSRRTLG | APDISSGTSD | TGSLPPNLQP | GYSPSPTHPP |
350:
TGQYTLFPLP | PTLPTPVVQL | HPLLPDPSAP | TPTPTSPLLN | TSYTHSQNLS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Dog
Pig
ELISA Kit for Human Thrombopoietin
ELISA Kit for Human Thrombopoietin
ELISA Kit for Human Thrombopoietin
ELISA Kit for Human Thrombopoietin
ELISA Kit for Human Thrombopoietin
CLIA Kit for Human Thrombopoietin
CLIA Kit for Human Thrombopoietin
CLIA Kit for Human Thrombopoietin
CLIA Kit for Human Thrombopoietin
CLIA Kit for Human Thrombopoietin
Polyclonal Antibody for Human Thrombopoietin
Polyclonal Antibody for Human Thrombopoietin
Polyclonal Antibody for Human Thrombopoietin
Polyclonal Antibody for Human Thrombopoietin
Polyclonal Antibody for Human Thrombopoietin
Monoclonal Antibody for Human Thrombopoietin
Monoclonal Antibody for Human Thrombopoietin
Monoclonal Antibody for Human Thrombopoietin
Monoclonal Antibody for Human Thrombopoietin
Monoclonal Antibody for Human Thrombopoietin
Protein for Human Thrombopoietin
Protein for Human Thrombopoietin
Protein for Human Thrombopoietin
Protein for Human Thrombopoietin
Protein for Human Thrombopoietin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand."
de Sauvage F.J.
,
Hass P.E.
,
Spencer S.D.
,
Malloy B.E.
,
Gurney A.L.
,
Spencer S.A.
,
Darbonne W.C.
,
Henzel W.J.
,
Wong S.C.
,
Kuang W.-J.
,
Oles K.J.
,
Hultgren B.
,
Solberg L.A. Jr.
,
Goeddel D.V.
,
Eaton D.L.
Nature369:533-538(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal liver .
2.
"Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl."
Bartley T.D.
,
Bogenberger J.
,
Hunt P.
,
Li Y.-S.
,
Lu H.S.
,
Martin F.
,
Chang M.-S.
,
Samal B.B.
,
Nichol J.L.
,
Swift S.
,
Johnson M.J.
,
Hsu R.-Y.
,
Parker V.P.
,
Suggs S.
,
Skrine J.D.
,
Merewether L.A.
,
Clogson C.
,
Hsu E.
,
Hokom M.M.
,
Hornkohl A.
,
Choi E.
,
Pangelinan M.
,
Sun Y.
,
Mar V.
,
McNich J.
,
Simonet L.
,
Jacobsen F.
,
Xie C.
,
Shutter J.
,
Chute H.
,
Basu R.
,
Selander L.
,
Trollinger D.
,
Sieu L.
,
Padilla D.
,
Trail G.
,
Elliott G.
,
Izumi R.
,
Covey T.
,
Crouse J.
,
Garcia A.
,
Xu W.
,
del Castillo J.
,
Biron J.
,
Cole S.
,
Hu M.C.-T.
,
Pacifici R.
,
Ponting I.
,
Saris C.
,
Wen D.
,
Yung Y.P.
,
Lin H.
,
Bosselman R.A.
more...
Cell77:1117-1124(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal liver .
3.
"Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization."
Foster D.C.
,
Sprecher C.A.
,
Grant F.J.
,
Kramer J.M.
,
Kuijper J.L.
,
Holly R.D.
,
Whitmore T.E.
,
Heipel M.D.
,
Bell L.A.N.
,
Ching A.F.
,
McGrane V.
,
Hart C.
,
O'Hara P.J.
,
Lok S.
Proc. Natl. Acad. Sci. U.S.A.91:13023-13027(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)
6.
"Purification and characterization of thrombopoietin."
Kato T.
,
Ogami K.
,
Shimada Y.
,
Iwamatsu A.
,
Sohma Y.
,
Akahori H.
,
Horie K.
,
Kokubo A.
,
Kudo Y.
,
Maeda E.
,
Kobayashi K.
,
Ohashi H.
,
Ozawa T.
,
Inoue H.
,
Kawamura K.
,
Miyazaki H.
J. Biochem.118:229-236(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
7.
"Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene."
Chang M.
,
McNinch J.
,
Basu R.
,
Shutter J.
,
Hsu R.
,
Perkins C.
,
Mar V.
,
Suggs S.
,
Welcher A.
,
Li L.
,
Lu H.
,
Bartley T.
,
Hunt P.
,
Martin F.
,
Samal B.
,
Bogenberger J.
J. Biol. Chem.270:511-514(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
tissue :
Placenta .
8.
"Cloning and sequencing of human thrombopoietin."
Im S.H.
,
Lee W.S.
,
Chung K.H.
Submitted (1996-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
tissue :
Testis .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISEASE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS;GLYCOSYLATION AT SER-22; THR-58; THR-131; THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255 AND SER-265
12.
"Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment."
Feese M.D.
,
Tamada T.
,
Kato Y.
,
Maeda Y.
,
Hirose M.
,
Matsukura Y.
,
Shigematsu H.
,
Muto T.
,
Matsumoto A.
,
Watarai H.
,
Ogami K.
,
Tahara T.
,
Kato T.
,
Miyazaki H.
,
Kuroki R.
Proc. Natl. Acad. Sci. U.S.A.101:1816-1821(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 22-184 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS