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Index > Protein center > TNFRSF10B(Gene name) > Human
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  • TNFRSF10B (Gene name),
  • Tumor necrosis factor receptor superfamily member 10B (Protein name ),  TR10B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFRSF10B(UNQ160/PRO186;DR5;KILLER;TRAILR2;TRICK2;ZTNFR9);
    Protein name:
    Tumor necrosis factor receptor superfamily member 10B;
    Alternative:
    TNF-related apoptosis-inducing ligand receptor 2(TRAIL receptor 2;TRAIL-R2);Death receptor 5;
    CD:
    CD262;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Can interact with TRADD and RIPK1.
    Function:
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    440
    Sequence:
    50:
    MEQRGQNAPA | ASGARKRHGP | GPREARGARP | GPRVPKTLVL | VVAAVLLLVS | 
    100:
    AESALITQQD | LAPQQRAAPQ | QKRSSPSEGL | CPPGHHISED | GRDCISCKYG | 
    150:
    QDYSTHWNDL | LFCLRCTRCD | SGEVELSPCT | TTRNTVCQCE | EGTFREEDSP | 
    200:
    EMCRKCRTGC | PRGMVKVGDC | TPWSDIECVH | KESGTKHSGE | VPAVEETVTS | 
    250:
    SPGTPASPCS | LSGIIIGVTV | AAVVLIVAVF | VCKSLLWKKV | LPYLKGICSG | 
    300:
    GGGDPERVDR | SSQRPGAEDN | VLNEIVSILQ | PTQVPEQEME | VQEPAEPTGV | 
    350:
    NMLSPGESEH | LLEPAEAERS | QRRRLLVPAN | EGDPTETLRQ | CFDDFADLVP | 
    400:
    FDSWEPLMRK | LGLMDNEIKV | AKAEAAGHRD | TLYTMLIKWV | NKTGRDASVH | 
    440:
    TLLDALETLG | ERLAKQKIED | HLLSSGKFMY | LEGNADSAMS | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 10B
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    E8953h
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 10B
    Cat.:
    E8953m
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 10B
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    U8953h
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 10B
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    U8953m
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    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B
    Cat.:
    P8953Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B
    Cat.:
    P8953Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B
    Protein for Human Tumor necrosis factor receptor superfamily member 10B
    Protein for Human Tumor necrosis factor receptor superfamily member 10B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL."
      Screaton G.R. , Mongkolsapaya J. , Xu X.-N. , Cowper A.E. , McMichael A.J. , Bell J.I.
      Curr. Biol.7:693-696(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT);ALTERNATIVE SPLICING;VARIANTS LEU-32; VAL-67 AND ALA-191
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);PROTEIN SEQUENCE OF N-TERMINUS;VARIANT ALA-191
      tissue: Foreskin fibroblast.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);CHARACTERIZATION;VARIANTS LEU-32; VAL-67 AND ALA-191
      tissue: Liver.
      tissue: Spleen.
    4. 4.
      "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."
      Chaudhary P.M. , Eby M. , Jasmin A. , Bookwalter A. , Murray J. , Hood L.
      Immunity7:821-830(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
    5. 5.
      "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
      MacFarlane M. , Ahmad M. , Srinivasula S.M. , Fernandes-Alnemri T. , Cohen G.M. , Alnemri E.S.
      J. Biol. Chem.272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
      tissue: Ovary.
    7. 7.
      "An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
      Pan G. , Ni J. , Wei Y.-F. , Yu G.-L. , Gentz R. , Dixit V.M.
      Science277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANT LEU-32
    9. 9.
      "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas."
      Arai T. , Akiyama Y. , Okabe S. , Saito K. , Iwai T. , Yuasa Y.
      Cancer Lett.133:197-204(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANTS LEU-32; VAL-67 AND ALA-191
    10. 10.
      Cao X. , Zhang W. , Wan T.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    11. 11.
      "Homo sapiens homolog of tumor necrosis factor receptor."
      Farrah T. , Vu T. , Gilbert T. , Gross J. , O'Hara P.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
    12. 12.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT);VARIANT LEU-32
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT LEU-32
      tissue: Colon endothelium.
    14. 15.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANTS LEU-32 AND ALA-191
      tissue: Cervix.
    15. 16.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    16. 17.
      "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."
      Yamaguchi H. , Wang H.G.
      J. Biol. Chem.279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    17. 18.
      "Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."
      Smith W. , Tomasec P. , Aicheler R. , Loewendorf A. , Nemcovicova I. , Wang E.C. , Stanton R.J. , Macauley M. , Norris P. , Willen L. , Ruckova E. , Nomoto A. , Schneider P. , Hahn G. , Zajonc D.M. , Ware C.F. , Wilkinson G.W. , Benedict C.A.
      Cell Host Microbe13:324-335(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL141
    18. 19.
      "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
      Hymowitz S.G. , Christinger H.W. , Fuh G. , Ultsch M. , O'Connell M. , Kelley R.F. , Ashkenazi A. , de Vos A.M.
      Mol. Cell4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 54-183
    19. 20.
      "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
      Mongkolsapaya J. , Grimes J.M. , Chen N. , Xu X.-N. , Stuart D.I. , Jones E.Y. , Screaton G.R.
      Nat. Struct. Biol.6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 69-184
    20. 21.
      "Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions."
      Nemcovicova I. , Benedict C.A. , Zajonc D.M.
      PLoS Pathog.9:E1003224-E1003224(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 58-184;INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL141
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