Gene name:
TNFRSF13B (TACI) ;
Protein name:
Tumor necrosis factor receptor superfamily member 13B ;
Alternative:
Transmembrane activator and CAML interactor ;
CD:
CD267 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus.
Function:
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Subcellular Location:
Membrane
Single-pass type III membrane protein
Protein Attributes:
50:
MSGLGRSRRG | GRSRVDQEER | FPQGLWTGVA | MRSCPEEQYW | DPLLGTCMSC |
100:
KTICNHQSQR | TCAAFCRSLS | CRKEQGKFYD | HLLRDCISCA | SICGQHPKQC |
150:
AYFCENKLRS | PVNLPPELRR | QRSGEVENNS | DNSGRYQGLE | HRGSEASPAL |
200:
PGLKLSADQV | ALVYSTLGLC | LCAVLCCFLV | AVACFLKKRG | DPCSCQPRSR |
250:
PRQSPAKSSQ | DHAMEAGSPV | STSPEPVETC | SFCFPECRAP | TQESAVTPGT |
293:
PDPTCAGRWG | CHTRTTVLQP | CPHIPDSGLG | IVCVPAQEGG | PGA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 13B
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 13B
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 13B
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 13B
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 13B
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 13B
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 13B
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 13B
Protein for Human Tumor necrosis factor receptor superfamily member 13B
Protein for Human Tumor necrosis factor receptor superfamily member 13B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
B-cell .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT LEU-251
tissue :
Spleen .
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.
"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS."
Wu Y.
,
Bressette D.
,
Carrell J.A.
,
Kaufman T.
,
Feng P.
,
Taylor K.
,
Gan Y.
,
Cho Y.H.
,
Garcia A.D.
,
Gollatz E.
,
Dimke D.
,
LaFleur D.
,
Migone T.S.
,
Nardelli B.
,
Wei P.
,
Ruben S.M.
,
Ullrich S.J.
,
Olsen H.S.
,
Kanakaraj P.
,
Moore P.A.
,
Baker K.P.
more...
J. Biol. Chem.275:35478-35485(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
"APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."
Yu G.
,
Boone T.
,
Delaney J.
,
Hawkins N.
,
Kelley M.J.
,
Ramakrishnan M.
,
McCabe S.
,
Qiu W.R.
,
Kornuc M.
,
Xia X.-Z.
,
Guo J.
,
Stolina M.
,
Boyle W.J.
,
Sarosi I.
,
Hsu H.
,
Senaldi G.
,
Theill L.E.
Nat. Immunol.1:252-256(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation."
Xia X.-Z.
,
Treanor J.
,
Senaldi G.
,
Khare S.D.
,
Boone T.
,
Kelley M.
,
Theill L.E.
,
Colombero A.
,
Solovyev I.
,
Lee F.
,
McCabe S.
,
Elliott R.
,
Miner K.
,
Hawkins N.
,
Guo J.
,
Stolina M.
,
Yu G.
,
Wang J.
,
Delaney J.
,
Meng S.-Y.
,
Boyle W.J.
,
Hsu H.
more...
J. Exp. Med.192:137-143(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRAF2 AND TRAF5
9.
"Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."
Hymowitz S.G.
,
Patel D.R.
,
Wallweber H.J.
,
Runyon S.
,
Yan M.
,
Yin J.
,
Shriver S.K.
,
Gordon N.C.
,
Pan B.
,
Skelton N.J.
,
Kelley R.F.
,
Starovasnik M.A.
J. Biol. Chem.280:7218-7227(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 68-109 IN COMPLEX WITH MOUSE TNFSF13;STRUCTURE BY NMR OF 68-109
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT IGAD2 ARG-104;VARIANTS CVID2 ARG-104; GLY-181 AND HIS-202
11.
"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I.
,
Tarpey P.
,
Raine K.
,
Huang D.
,
Ong C.K.
,
Stephens P.
,
Davies H.
,
Jones D.
,
Lin M.L.
,
Teague J.
,
Bignell G.
,
Butler A.
,
Cho J.
,
Dalgliesh G.L.
,
Galappaththige D.
,
Greenman C.
,
Hardy C.
,
Jia M.
,
Latimer C.
,
Lau K.W.
,
Marshall J.
,
McLaren S.
,
Menzies A.
,
Mudie L.
,
Stebbings L.
,
Largaespada D.A.
,
Wessels L.F.A.
,
Richard S.
,
Kahnoski R.J.
,
Anema J.
,
Tuveson D.A.
,
Perez-Mancera P.A.
,
Mustonen V.
,
Fischer A.
,
Adams D.J.
,
Rust A.
,
Chan-On W.
,
Subimerb C.
,
Dykema K.
,
Furge K.
,
Campbell P.J.
,
Teh B.T.
,
Stratton M.R.
,
Futreal P.A.
more...
Nature469:539-542(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASN-56