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Index > Protein center > TRAF6(Gene name) > Human
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  • TRAF6 (Gene name),
  • TNF receptor-associated factor 6 (Protein name ),  TRAF6_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    TRAF6(RNF85);
    Protein name:
    TNF receptor-associated factor 6;
    Alternative:
    Interleukin-1 signal transducer;E3 ubiquitin-protein ligase TRAF6;RING finger protein 85;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with JUB. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1.
    Function:
    E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.
    Subcellular Location:
    Cytoplasm Cytoplasm cell cortex Nucleus Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T-and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus.
    Protein Attributes:
    Sequence length:
    522
    Sequence:
    50:
    MSLLNCENSC | GSSQSESDCC | VAMASSCSAV | TKDDSVGGTA | STGNLSSSFM | 
    100:
    EEIQGYDVEF | DPPLESKYEC | PICLMALREA | VQTPCGHRFC | KACIIKSIRD | 
    150:
    AGHKCPVDNE | ILLENQLFPD | NFAKREILSL | MVKCPNEGCL | HKMELRHLED | 
    200:
    HQAHCEFALM | DCPQCQRPFQ | KFHINIHILK | DCPRRQVSCD | NCAASMAFED | 
    250:
    KEIHDQNCPL | ANVICEYCNT | ILIREQMPNH | YDLDCPTAPI | PCTFSTFGCH | 
    300:
    EKMQRNHLAR | HLQENTQSHM | RMLAQAVHSL | SVIPDSGYIS | EVRNFQETIH | 
    350:
    QLEGRLVRQD | HQIRELTAKM | ETQSMYVSEL | KRTIRTLEDK | VAEIEAQQCN | 
    400:
    GIYIWKIGNF | GMHLKCQEEE | KPVVIHSPGF | YTGKPGYKLC | MRLHLQLPTA | 
    450:
    QRCANYISLF | VHTMQGEYDS | HLPWPFQGTI | RLTILDQSEA | PVRQNHEEIM | 
    500:
    DAKPELLAFQ | RPTIPRNPKG | FGYVTFMHLE | ALRQRTFIKD | DTLLVRCEVS | 
    522:
    TRFDMGSLRR | EGFQPRSTDA | GV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human TNF receptor-associated factor 6
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    ELISA Kit for Human TNF receptor-associated factor 6
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    ELISA Kit for Human TNF receptor-associated factor 6
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    ELISA Kit for Human TNF receptor-associated factor 6
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    ELISA Kit for Human TNF receptor-associated factor 6
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    CLIA Kit for Human TNF receptor-associated factor 6
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    CLIA Kit for Human TNF receptor-associated factor 6
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    CLIA Kit for Human TNF receptor-associated factor 6
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    CLIA Kit for Human TNF receptor-associated factor 6
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    U8869h
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    CLIA Kit for Human TNF receptor-associated factor 6
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    Polyclonal Antibody for Human TNF receptor-associated factor 6
    Polyclonal Antibody for Human TNF receptor-associated factor 6
    Polyclonal Antibody for Human TNF receptor-associated factor 6
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    P8869Rb-m
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    Packing:
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    Polyclonal Antibody for Human TNF receptor-associated factor 6
    Polyclonal Antibody for Human TNF receptor-associated factor 6
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    P8869Rb-h
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    Packing:
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    Monoclonal Antibody for Human TNF receptor-associated factor 6
    Monoclonal Antibody for Human TNF receptor-associated factor 6
    Monoclonal Antibody for Human TNF receptor-associated factor 6
    Monoclonal Antibody for Human TNF receptor-associated factor 6
    Monoclonal Antibody for Human TNF receptor-associated factor 6
    Protein for Human TNF receptor-associated factor 6
    Protein for Human TNF receptor-associated factor 6
    Protein for Human TNF receptor-associated factor 6
    Protein for Human TNF receptor-associated factor 6
    Protein for Human TNF receptor-associated factor 6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "TRAF6 is a signal transducer for interleukin-1."
      Cao Z. , Xiong J. , Takeuchi M. , Kurama T. , Goeddel D.V.
      Nature383:443-446(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH IRAK1
    2. 2.
      SeattleSNPs variation discovery resource
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    7. 7.
      "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."
      Malinin N.L. , Boldin M.P. , Kovalenko A.V. , Wallach D.
      Nature385:540-544(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K14
    8. 8.
      "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling."
      Muzio M. , Ni J. , Feng P. , Dixit V.M.
      Science278:1612-1615(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRAK2
    9. 9.
      "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase."
      McCarthy J.V. , Ni J. , Dixit V.M.
      J. Biol. Chem.273:16968-16975(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK2
    10. 10.
      "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
      Wong B.R. , Josien R. , Lee S.Y. , Vologodskaia M. , Steinman R.M. , Choi Y.
      J. Biol. Chem.273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF11A
    11. 11.
      "Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway."
      Kashiwada M. , Shirakata Y. , Inoue J. , Nakano H. , Okazaki K. , Okumura K. , Yamamoto T. , Nagaoka H. , Takemori T.
      J. Exp. Med.187:237-244(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF5
    12. 12.
      "ASK1 is essential for JNK/SAPK activation by TRAF2."
      Nishitoh H. , Saitoh M. , Mochida Y. , Takeda K. , Nakano H. , Rothe M. , Miyazono K. , Ichijo H.
      Mol. Cell2:389-395(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K5
    13. 13.
      "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain."
      Baud V. , Liu Z.-G. , Bennett B. , Suzuki N. , Xia Y. , Karin M.
      Genes Dev.13:1297-1308(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K1
    14. 14.
      "Association of the p75 neurotrophin receptor with TRAF6."
      Khursigara G. , Orlinick J.R. , Chao M.V.
      J. Biol. Chem.274:2597-2600(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGFR
    15. 15.
      "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family."
      Wesche H. , Gao X. , Li X. , Kirschning C.J. , Stark G.R. , Cao Z.
      J. Biol. Chem.274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRAK3
    16. 16.
      "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."
      Ye X. , Mehlen P. , Rabizadeh S. , VanArsdale T. , Zhang H. , Shin H. , Wang J.J.L. , Leo E. , Zapata J.M. , Hauser C.A. , Reed J.C. , Bredesen D.E.
      J. Biol. Chem.274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGFR
    17. 17.
      "TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src."
      Wong B.R. , Besser D. , Kim N. , Arron J.R. , Vologodskaia M. , Hanafusa H. , Choi Y.
      Mol. Cell4:1041-1049(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF11A AND CSK
    18. 18.
      "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
      Ninomiya-Tsuji J. , Kishimoto K. , Hiyama A. , Inoue J. , Cao Z. , Matsumoto K.
      Nature398:252-256(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K7 AND TAB1
    19. 19.
      "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)."
      Hoeflich K.P. , Yeh W.C. , Yao Z. , Mak T.W. , Woodgett J.R.
      Oncogene18:5814-5820(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K5
    20. 20.
      "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain."
      Deng L. , Wang C. , Spencer E. , Yang L. , Braun A. , You J. , Slaughter C. , Pickart C. , Chen Z.J.
      Cell103:351-361(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2V1;FUNCTION AS AN E3 UBIQUITIN LIGASE
    21. 21.
      "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."
      Pype S. , Declercq W. , Ibrahimi A. , Michiels C. , Van Rietschoten J.G.I. , Dewulf N. , de Boer M. , Vandenabeele P. , Huylebroeck D. , Remacle J.E.
      J. Biol. Chem.275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TDP2
    22. 22.
      "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1."
      Shu H.-B. , Johnson H.
      Proc. Natl. Acad. Sci. U.S.A.97:9156-9161(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF17
    23. 23.
      "T6BP, a TRAF6-interacting protein involved in IL-1 signaling."
      Ling L. , Goeddel D.V.
      Proc. Natl. Acad. Sci. U.S.A.97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAX1BP1
    24. 24.
      "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
      Wang C. , Deng L. , Hong M. , Akkaraju G.R. , Inoue J. , Chen Z.J.
      Nature412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    25. 25.
      "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6."
      Kanamori M. , Kai C. , Hayashizaki Y. , Suzuki H.
      FEBS Lett.532:241-246(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF3IP2
    26. 26.
      "A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6."
      Shin J.N. , Kim I. , Lee J.S. , Koh G.Y. , Lee Z.H. , Kim H.-H.
      J. Biol. Chem.277:8346-8353(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF675
    27. 27.
      "IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase."
      Li S. , Strelow A. , Fontana E.J. , Wesche H.
      Proc. Natl. Acad. Sci. U.S.A.99:5567-5572(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRAK4
    28. 28.
      "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex."
      Jiang Z. , Johnson H.J. , Nie H. , Qin J. , Bird T.A. , Li X.
      J. Biol. Chem.278:10952-10956(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELI1
    29. 29.
      "Pellino2 activates the mitogen activated protein kinase pathway."
      Jensen L.E. , Whitehead A.S.
      FEBS Lett.545:199-202(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELI1 AND PELI2
    30. 30.
      "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
      Bin L.-H. , Xu L.-G. , Shu H.-B.
      J. Biol. Chem.278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM2
    31. 31.
      "Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein."
      Jensen L.E. , Whitehead A.S.
      J. Immunol.171:1500-1506(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELI3
    32. 32.
      "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
      Sato S. , Sugiyama M. , Yamamoto M. , Watanabe Y. , Kawai T. , Takeda K. , Akira S.
      J. Immunol.171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1
    33. 33.
      "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."
      Han K.J. , Su X. , Xu L.-G. , Bin L.H. , Zhang J. , Shu H.-B.
      J. Biol. Chem.279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1
    34. 34.
      "ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation."
      Huang J. , Teng L. , Li L. , Liu T. , Li L. , Chen D. , Xu L.-G. , Zhai Z. , Shu H.-B.
      J. Biol. Chem.279:16847-16853(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFAND5
    35. 35.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF2AK2
    36. 36.
      "Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta."
      Jiang Z. , Mak T.W. , Sen G. , Li X.
      Proc. Natl. Acad. Sci. U.S.A.101:3533-3538(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1
    37. 37.
      "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3."
      Seth R.B. , Sun L. , Ea C.-K. , Chen Z.J.
      Cell122:669-682(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS
    38. 38.
      "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
      Schmitz J. , Owyang A. , Oldham E. , Song Y. , Murphy E. , McClanahan T.K. , Zurawski G. , Moshrefi M. , Qin J. , Li X. , Gorman D.M. , Bazan J.F. , Kastelein R.A.
      Immunity23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL1RL1
    39. 39.
      "FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling."
      Mashima R. , Saeki K. , Aki D. , Minoda Y. , Takaki H. , Sanada T. , Kobayashi T. , Aburatani H. , Yamanashi Y. , Yoshimura A.
      J. Biol. Chem.280:41289-41297(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAFD1
    40. 40.
      "VISA is an adapter protein required for virus-triggered IFN-beta Signaling."
      Xu L.-G. , Wang Y.-Y. , Han K.-J. , Li L.-Y. , Zhai Z. , Shu H.-B.
      Mol. Cell19:727-740(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS
    41. 41.
      "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex."
      Feng Y. , Longmore G.D.
      Mol. Cell. Biol.25:4010-4022(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AJUBA
    42. 42.
      "Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling."
      Wang Y. , Tang Y. , Teng L. , Wu Y. , Zhao X. , Pei G.
      Nat. Immunol.7:139-147(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTIONAL ACTIVATION OF NF-KAPPA-B AND JUN;INTERACTION WITH ARBB1 AND ARBB2
    43. 43.
      "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
      Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
      Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH IRAK1; IRAK4; MYD88 AND PELI1
    44. 44.
      "Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation."
      Lamothe B. , Besse A. , Campos A.D. , Webster W.K. , Wu H. , Darnay B.G.
      J. Biol. Chem.282:4102-4112(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-70 AND LYS-124;UBIQUITINATION AT LYS-124;FUNCTION
    45. 45.
      "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
      Tian Y. , Zhang Y. , Zhong B. , Wang Y.Y. , Diao F.C. , Wang R.P. , Zhang M. , Chen D.Y. , Zhai Z.H. , Shu H.B.
      J. Biol. Chem.282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBCK1
    46. 46.
      "Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification."
      Pham L.V. , Zhou H.J. , Lin-Lee Y.C. , Tamayo A.T. , Yoshimura L.C. , Fu L. , Darnay B.G. , Ford R.J.
      J. Biol. Chem.283:5081-5089(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;SUMOYLATION AT LYS-124; LYS-142 AND LYS-453;UBIQUITINATION;INTERACTION WITH HDAC1 AND RANGAP1;MUTAGENESIS OF LYS-124; LYS-142 AND LYS-453
    47. 47.
      "Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation."
      Conze D.B. , Wu C.J. , Thomas J.A. , Landstrom A. , Ashwell J.D.
      Mol. Cell. Biol.28:3538-3547(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OR IRAK1
    48. 48.
      "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner."
      Sorrentino A. , Thakur N. , Grimsby S. , Marcusson A. , von Bulow V. , Schuster N. , Zhang S. , Heldin C.H. , Landstrom M.
      Nat. Cell Biol.10:1199-1207(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TGFBR1;UBIQUITINATION
    49. 49.
      "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
      Gao D. , Wang R. , Li B. , Yang Y. , Zhai Z. , Chen D.Y.
      Cell. Mol. Life Sci.66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR34
    50. 50.
      "Direct activation of protein kinases by unanchored polyubiquitin chains."
      Xia Z.-P. , Sun L. , Chen X. , Pineda G. , Jiang X. , Adhikari A. , Zeng W. , Chen Z.J.
      Nature461:114-119(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION
    51. 51.
      "The E3 ligase TRAF6 regulates Akt ubiquitination and activation."
      Yang W.-L. , Wang J. , Chan C.-H. , Lee S.-W. , Campos A.D. , Lamothe B. , Hur L. , Grabiner B.C. , Lin X. , Darnay B.G. , Lin H.-K.
      Science325:1134-1138(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    52. 52.
      "NUMBL interacts with TRAF6 and promotes the degradation of TRAF6."
      Zhou L. , Ma Q. , Shi H. , Huo K.
      Biochem. Biophys. Res. Commun.392:409-414(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUMBL
    53. 53.
      "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."
      Scudiero I. , Zotti T. , Ferravante A. , Vessichelli M. , Vito P. , Stilo R.
      J. Cell. Physiol.226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD14
    54. 54.
      "IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1."
      Liu X.Y. , Chen W. , Wei B. , Shan Y.F. , Wang C.
      J. Immunol.187:2559-2568(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFIT3
    55. 55.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 347-506 OF APOPROTEIN AND IN COMPLEXES WITH TNFRSF5 AND TNFRSF11A PEPTIDES;FUNCTION;SUBUNIT
    56. 56.
      "Structure, interactions, and dynamics of the RING domain from human TRAF6."
      Mercier P. , Lewis M.J. , Hau D.D. , Saltibus L.F. , Xiao W. , Spyracopoulos L.
      Protein Sci.16:602-614(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 63-124 IN COMPLEX WITH ZINC IONS;INTERACTION WITH UBE2N
    57. 57.
      "Solution structure of the RING domain of the human TNF receptor-associated factor 6 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2008-03) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 43-128
    58. 58.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 50-211 IN COMPLEXES WITH ZINC IONS AND UBE2N;SUBUNIT;FUNCTION;AUTOUBIQUITINATION;MUTAGENESIS OF ASP-57; CYS-70; ILE-72; LEU-74; ARG-88; PHE-118; PHE-122 AND LYS-124;ZINC-FINGER
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