Traf6 ELISA Kit for Mouse(Mus musculus) | EIAab.comTraf6 ELISA Kit for Mouse(Mus musculus)

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Traf6 (Gene name),

TNF receptor-associated factor 6 (Protein name ), TRAF6_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Traf6;

Protein name:

TNF receptor-associated factor 6;

Alternative:

E3 ubiquitin-protein ligase TRAF6;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer (By similarity). Homooligomer (By similarity). N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK (By similarity). Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, PELI1, PELI2, PELI3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1 (By similarity). Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with IL1RL1. Interacts with JUB (By similarity). Interacts with TRAFD1. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2 (By similarity). Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal) (By similarity). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1.

Function:

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.

Subcellular Location:

Cytoplasm Cytoplasm cell cortex Nucleus

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

LLVRCEVSTR | FDMGGLRKEG | FQPRSTDAGV |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:22034

UniGene:

Mm.292729

String:

P70196

STRING:

10090.ENSMUSP00000004949

SMR:

P70196

Pfam:

PF00917

Uniprot:

P70196

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ELISA Kit for Mouse TNF receptor-associated factor 6

Cat.:

E8869h

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96T

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ELISA Kit for Mouse TNF receptor-associated factor 6

Cat.:

E8869r

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96T

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ELISA Kit for Mouse TNF receptor-associated factor 6

Cat.:

E8869m

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96T

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ELISA Kit for Mouse TNF receptor-associated factor 6

Cat.:

E8869p

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96T

ELISA Kit for Mouse TNF receptor-associated factor 6

Cat.:

E8869b

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96T

CLIA Kit for Mouse TNF receptor-associated factor 6

Cat.:

U8869m

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96T

CLIA Kit for Mouse TNF receptor-associated factor 6

Cat.:

U8869b

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96T

CLIA Kit for Mouse TNF receptor-associated factor 6

Cat.:

U8869p

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MSDS:

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Packing:

96T

CLIA Kit for Mouse TNF receptor-associated factor 6

Cat.:

U8869h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse TNF receptor-associated factor 6

Cat.:

U8869r

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96T

Polyclonal Antibody for Mouse TNF receptor-associated factor 6

Cat.:

P8869Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse TNF receptor-associated factor 6

Cat.:

P8869Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse TNF receptor-associated factor 6

Protein for Mouse TNF receptor-associated factor 6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region."
Ishida T. , Mizushima S. , Azuma S. , Kobayashi N. , Tojo T. , Suzuki K. , Aizawa S. , Watanabe T. , Mosialos G. , Kieff E. , Yamamoto T. , Inoue J.
J. Biol. Chem.271:28745-28748(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/Kaplan.
tissue: T-cell lymphoma.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6J.
tissue: Aorta.
tissue: Vein.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2009-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
5.

"Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice."
Naito A. , Azuma S. , Tanaka S. , Miyazaki T. , Takaki S. , Takatsu K. , Nakao K. , Nakamura K. , Katsuki M. , Yamamoto T. , Inoue J.
Genes Cells4:353-362(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
6.

"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling."
Lomaga M.A. , Yeh W.C. , Sarosi I. , Duncan G.S. , Furlonger C. , Ho A. , Morony S. , Capparelli C. , Van G. , Kaufman S. , van der Heiden A. , Itie A. , Wakeham A. , Khoo W. , Sasaki T. , Cao Z. , Penninger J.M. , Paige C.J. , more...
Genes Dev.13:1015-1024(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway."
Sanz L. , Diaz-Meco M.T. , Nakano H. , Moscat J.
EMBO J.19:1576-1586(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1 AND PRKCZ
8.

"Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction."
Schwandner R. , Yamaguchi K. , Cao Z.
J. Exp. Med.191:1233-1240(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL17R
9.

"The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."
Wooten M.W. , Seibenhener M.L. , Mamidipudi V. , Diaz-Meco M.T. , Barker P.A. , Moscat J.
J. Biol. Chem.276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1; PRKCZ AND NGFR
10.

"TRAF6-deficient mice display hypohidrotic ectodermal dysplasia."
Naito A. , Yoshida H. , Nishioka E. , Satoh M. , Azuma S. , Yamamoto T. , Nishikawa S. , Inoue J.
Proc. Natl. Acad. Sci. U.S.A.99:8766-8771(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
11.

"Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40."
Eliopoulos A.G. , Wang C.C. , Dumitru C.D. , Tsichlis P.N.
EMBO J.22:3855-3864(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CD40 AND MAP3K8
12.

"TRAF6 is a critical factor for dendritic cell maturation and development."
Kobayashi T. , Walsh P.T. , Walsh M.C. , Speirs K.M. , Chiffoleau E. , King C.G. , Hancock W.W. , Caamano J.H. , Hunter C.A. , Scott P. , Turka L.A. , Choi Y.
Immunity19:353-363(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
13.

"TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling."
Gohda J. , Matsumura T. , Inoue J.
J. Immunol.173:2913-2917(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
14.

"The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination."
Wooten M.W. , Geetha T. , Seibenhener M.L. , Babu J.R. , Diaz-Meco M.T. , Moscat J.
J. Biol. Chem.280:35625-35629(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
15.

"Dependence of self-tolerance on TRAF6-directed development of thymic stroma."
Akiyama T. , Maeda S. , Yamane S. , Ogino K. , Kasai M. , Kajiura F. , Matsumoto M. , Inoue J.
Science308:248-251(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
16.

"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH IRAK1; IRAK4; MYD88 AND PELI1
17.

"Characteristics and biological functions of TRAF6."
Inoue J. , Gohda J. , Akiyama T.
Adv. Exp. Med. Biol.597:72-79(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
18.

"The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development."
Feng Y. , Zhao H. , Luderer H.F. , Epple H. , Faccio R. , Ross F.P. , Teitelbaum S.L. , Longmore G.D.
J. Biol. Chem.282:39-48(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LIMD1
19.

"FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway."
Sanada T. , Takaesu G. , Mashima R. , Yoshida R. , Kobayashi T. , Yoshimura A.
J. Biol. Chem.283:33858-33864(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAFD1
20.

"Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells."
Saitoh T. , Satoh T. , Yamamoto N. , Uematsu S. , Takeuchi O. , Kawai T. , Akira S.
Immunity34:352-363(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RSAD2;SUBCELLULAR LOCATION

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