Protein name:
Triggering receptor expressed on myeloid cells 2 (TREM-2) ;
Alternative:
Triggering receptor expressed on monocytes 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TYROBP/DAP12.
Function:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
Subcellular Location:
Isoform 3
Secreted
Protein Attributes:
50:
MEPLRLLILL | FVTELSGAHN | TTVFQGVAGQ | SLQVSCPYDS | MKHWGRRKAW |
100:
CRQLGEKGPC | QRVVSTHNLW | LLSFLRRWNG | STAITDDTLG | GTLTITLRNL |
150:
QPHDAGLYQC | QSLHGSEADT | LRKVLVEVLA | DPLDHRDAGD | LWFPGESESF |
200:
EDAHVEHSIS | RSLLEGEIPF | PPTSILLLLA | CIFLIKILAA | SALWAAAWHG |
230:
QKPGTHPPSE | LDCGHDPGYQ | LQTLPGLRDT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human TREM-2
ELISA Kit for Human TREM-2
CLIA Kit for Human TREM-2
CLIA Kit for Human TREM-2
Polyclonal Antibody for Human TREM-2
Polyclonal Antibody for Human TREM-2
Monoclonal Antibody for Human TREM-2
Monoclonal Antibody for Human TREM-2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
2.
"Identification of a novel variant of triggering receptor, TREM-2V, by mRNA differential display."
Begum N.A.
,
Tsukasa S.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Brain .
4.
"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype."
Paloneva J.
,
Manninen T.
,
Christman G.
,
Hovanes K.
,
Mandelin J.
,
Adolfsson R.
,
Bianchin M.
,
Bird T.
,
Miranda R.
,
Salmaggi A.
,
Tranebjaerg L.
,
Konttinen Y.
,
Peltonen L.
Am. J. Hum. Genet.71:656-662(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;VARIANTS PLOSL GLY-134 AND ASN-186
5.
Paloneva J.
,
Manninen T.
,
Christman G.
,
Hovanes K.
,
Mandelin J.
,
Adolfsson R.
,
Bianchin M.
,
Bird T.
,
Miranda R.
,
Salmaggi A.
,
Tranebjaerg L.
,
Konttinen Y.
,
Peltonen L.
Am. J. Hum. Genet.72:225-225(2003)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM