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Index > Protein center > TRIM63(Gene name) > Human
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  • TRIM63 (Gene name),
  • E3 ubiquitin-protein ligase TRIM63 (Protein name ),  TRI63_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TRIM63(IRF;MURF1;RNF28;SMRZ);
    Protein name:
    E3 ubiquitin-protein ligase TRIM63;
    Alternative:
    Muscle-specific RING finger protein 1(MuRF-1;MuRF1);Iris RING finger protein;Striated muscle RING zinc finger protein;RING finger protein 28;Tripartite motif-containing protein 63;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE.
    Function:
    E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
    Subcellular Location:
    Cytoplasm Nucleus Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
    Protein Attributes:
    Sequence length:
    353
    Sequence:
    50:
    MDYKSSLIQD | GNPMENLEKQ | LICPICLEMF | TKPVVILPCQ | HNLCRKCAND | 
    100:
    IFQAANPYWT | SRGSSVSMSG | GRFRCPTCRH | EVIMDRHGVY | GLQRNLLVEN | 
    150:
    IIDIYKQECS | SRPLQKGSHP | MCKEHEDEKI | NIYCLTCEVP | TCSMCKVFGI | 
    200:
    HKACEVAPLQ | SVFQGQKTEL | NNCISMLVAG | NDRVQTIITQ | LEDSRRVTKE | 
    250:
    NSHQVKEELS | QKFDTLYAIL | DEKKSELLQR | ITQEQEKKLS | FIEALIQQYQ | 
    300:
    EQLDKSTKLV | ETAIQSLDEP | GGATFLLTAK | QLIKSIVEAS | KGCQLGKTEQ | 
    350:
    GFENMDFFTL | DLEHIADALR | AIDFGTDEEE | EEFIEEEDQE | EEESTEGKEE | 
    353:
    GHQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    UniGene:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase TRIM63
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    E5054r
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    ELISA Kit for Human E3 ubiquitin-protein ligase TRIM63
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    E5054m
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    Packing:
    96T
    ELISA Kit for Human E3 ubiquitin-protein ligase TRIM63
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    E5054h
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    Packing:
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    CLIA Kit for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054r
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    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM63
    Protein for Human E3 ubiquitin-protein ligase TRIM63
    Protein for Human E3 ubiquitin-protein ligase TRIM63
    Protein for Human E3 ubiquitin-protein ligase TRIM63

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain."
      Centner T. , Yano J. , Kimura E. , McElhinny A.S. , Pelin K. , Witt C.C. , Bang M.-L. , Trombitas K. , Granzier H. , Gregorio C.C. , Sorimachi H. , Labeit S.
      J. Mol. Biol.306:717-726(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-237;INTERACTION WITH TTN; TRIM54 AND TRIM55;SUBUNIT;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
    2. 2.
      "Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium."
      Wistow G. , Bernstein S.L. , Ray S. , Wyatt M.K. , Behal A. , Touchman J.W. , Bouffard G. , Smith D. , Peterson K.
      Mol. Vis.8:185-195(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Iris.
    3. 3.
      "Characterisation of MURF2, a new muscle-specific RING finger protein of the RBCC family that associates with microtubules."
      Stanchi F.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Skeletal muscle.
    4. 4.
      "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain."
      Dai K.-S. , Liew C.-C.
      J. Biol. Chem.276:23992-23999(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH SUMO2;MUTAGENESIS OF CYS-39; HIS-41; CYS-44 AND CYS-47;DOMAIN
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Heart.
      tissue: Skeletal muscle.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-237
      tissue: Skin.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1."
      McElhinny A.S. , Kakinuma K. , Sorimachi H. , Labeit S. , Gregorio C.C.
      J. Cell Biol.157:125-136(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DOMAIN;FUNCTION;INTERACTION WITH GMEB1
    10. 10.
      "MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies."
      Hirner S. , Krohne C. , Schuster A. , Hoffmann S. , Witt S. , Erber R. , Sticht C. , Gasch A. , Labeit S. , Labeit D.
      J. Mol. Biol.379:666-677(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 11.
      "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis."
      Koyama S. , Hata S. , Witt C.C. , Ono Y. , Lerche S. , Ojima K. , Chiba T. , Doi N. , Kitamura F. , Tanaka K. , Abe K. , Witt S.H. , Rybin V. , Gasch A. , Franz T. , Labeit S. , Sorimachi H.
      J. Mol. Biol.376:1224-1236(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CKM;FUNCTION
    12. 12.
      "Solution structure of the B-box domain of the human tripartite motif-containing 63 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 119-169
    13. 13.
      "Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold."
      Mrosek M. , Meier S. , Ucurum-Fotiadis Z. , von Castelmur E. , Hedbom E. , Lustig A. , Grzesiek S. , Labeit D. , Labeit S. , Mayans O.
      Biochemistry47:10722-10730(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 117-161 IN COMPLEX WITH ZINC IONS;DOMAIN;SUBUNIT
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