Protein name:
Transient receptor potential cation channel subfamily V member 1 (TrpV1) ;
Alternative:
Osm-9-like TRP channel 1 (OTRPC1) ;Capsaicin receptor ;Vanilloid receptor 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.
Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
Multi-pass membrane protein
Cell projection
dendritic spine membrane
Multi-pass membrane protein
Protein Attributes:
50:
MKKWSSTDLG | AAADPLQKDT | CPDPLDGDPN | SRPPPAKPQL | STAKSRTRLF |
100:
GKGDSEEAFP | VDCPHEEGEL | DSCPTITVSP | VITIQRPGDG | PTGARLLSQD |
150:
SVAASTEKTL | RLYDRRSIFE | AVAQNNCQDL | ESLLLFLQKS | KKHLTDNEFK |
200:
DPETGKTCLL | KAMLNLHDGQ | NTTIPLLLEI | ARQTDSLKEL | VNASYTDSYY |
250:
KGQTALHIAI | ERRNMALVTL | LVENGADVQA | AAHGDFFKKT | KGRPGFYFGE |
300:
LPLSLAACTN | QLGIVKFLLQ | NSWQTADISA | RDSVGNTVLH | ALVEVADNTA |
350:
DNTKFVTSMY | NEILMLGAKL | HPTLKLEELT | NKKGMTPLAL | AAGTGKIGVL |
400:
AYILQREIQE | PECRHLSRKF | TEWAYGPVHS | SLYDLSCIDT | CEKNSVLEVI |
450:
AYSSSETPNR | HDMLLVEPLN | RLLQDKWDRF | VKRIFYFNFL | VYCLYMIIFT |
500:
MAAYYRPVDG | LPPFKMEKTG | DYFRVTGEIL | SVLGGVYFFF | RGIQYFLQRR |
550:
PSMKTLFVDS | YSEMLFFLQS | LFMLATVVLY | FSHLKEYVAS | MVFSLALGWT |
600:
NMLYYTRGFQ | QMGIYAVMIE | KMILRDLCRF | MFVYIVFLFG | FSTAVVTLIE |
650:
DGKNDSLPSE | STSHRWRGPA | CRPPDSSYNS | LYSTCLELFK | FTIGMGDLEF |
700:
TENYDFKAVF | IILLLAYVIL | TYILLLNMLI | ALMGETVNKI | AQESKNIWKL |
750:
QRAITILDTE | KSFLKCMRKA | FRSGKLLQVG | YTPDGKDDYR | WCFRVDEVNW |
800:
TTWNTNVGII | NEDPGNCEGV | KRTLSFSLRS | SRVSGRHWKN | FALVPLLREA |
839:
SARDRQSAQP | EEVYLRQFSG | SLKPEDAEVF | KSPAASGEK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Rabbit
Dog
Human
Mouse
ELISA Kit for Human TrpV1
ELISA Kit for Human TrpV1
ELISA Kit for Human TrpV1
ELISA Kit for Human TrpV1
ELISA Kit for Human TrpV1
Polyclonal Antibody for Human TrpV1
Polyclonal Antibody for Human TrpV1
Polyclonal Antibody for Human TrpV1
Polyclonal Antibody for Human TrpV1
Polyclonal Antibody for Human TrpV1
Monoclonal Antibody for Human TrpV1
Monoclonal Antibody for Human TrpV1
Monoclonal Antibody for Human TrpV1
Monoclonal Antibody for Human TrpV1
Monoclonal Antibody for Human TrpV1
R&D Technical Data
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Precision
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Recovery
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Linearity
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