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Index > Protein center > TRPV1(Gene name) > Human
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  • TRPV1 (Gene name),
  • Transient receptor potential cation channel subfamily V member 1 (Protein name ),  TRPV1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TRPV1(VR1);
    Protein name:
    Transient receptor potential cation channel subfamily V member 1(TrpV1);
    Alternative:
    Osm-9-like TRP channel 1(OTRPC1);Capsaicin receptor;Vanilloid receptor 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.
    Function:
    Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell projection dendritic spine membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    839
    Sequence:
    50:
    MKKWSSTDLG | AAADPLQKDT | CPDPLDGDPN | SRPPPAKPQL | STAKSRTRLF | 
    100:
    GKGDSEEAFP | VDCPHEEGEL | DSCPTITVSP | VITIQRPGDG | PTGARLLSQD | 
    150:
    SVAASTEKTL | RLYDRRSIFE | AVAQNNCQDL | ESLLLFLQKS | KKHLTDNEFK | 
    200:
    DPETGKTCLL | KAMLNLHDGQ | NTTIPLLLEI | ARQTDSLKEL | VNASYTDSYY | 
    250:
    KGQTALHIAI | ERRNMALVTL | LVENGADVQA | AAHGDFFKKT | KGRPGFYFGE | 
    300:
    LPLSLAACTN | QLGIVKFLLQ | NSWQTADISA | RDSVGNTVLH | ALVEVADNTA | 
    350:
    DNTKFVTSMY | NEILMLGAKL | HPTLKLEELT | NKKGMTPLAL | AAGTGKIGVL | 
    400:
    AYILQREIQE | PECRHLSRKF | TEWAYGPVHS | SLYDLSCIDT | CEKNSVLEVI | 
    450:
    AYSSSETPNR | HDMLLVEPLN | RLLQDKWDRF | VKRIFYFNFL | VYCLYMIIFT | 
    500:
    MAAYYRPVDG | LPPFKMEKTG | DYFRVTGEIL | SVLGGVYFFF | RGIQYFLQRR | 
    550:
    PSMKTLFVDS | YSEMLFFLQS | LFMLATVVLY | FSHLKEYVAS | MVFSLALGWT | 
    600:
    NMLYYTRGFQ | QMGIYAVMIE | KMILRDLCRF | MFVYIVFLFG | FSTAVVTLIE | 
    650:
    DGKNDSLPSE | STSHRWRGPA | CRPPDSSYNS | LYSTCLELFK | FTIGMGDLEF | 
    700:
    TENYDFKAVF | IILLLAYVIL | TYILLLNMLI | ALMGETVNKI | AQESKNIWKL | 
    750:
    QRAITILDTE | KSFLKCMRKA | FRSGKLLQVG | YTPDGKDDYR | WCFRVDEVNW | 
    800:
    TTWNTNVGII | NEDPGNCEGV | KRTLSFSLRS | SRVSGRHWKN | FALVPLLREA | 
    839:
    SARDRQSAQP | EEVYLRQFSG | SLKPEDAEVF | KSPAASGEK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human TrpV1
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    E12152r
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    ELISA Kit for Human TrpV1
    MSDS:
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    ELISA Kit for Human TrpV1
    MSDS:
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    ELISA Kit for Human TrpV1
    Cat.:
    E12152h
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    96T
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    ELISA Kit for Human TrpV1
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    E12152m
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    96T
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    CLIA Kit for Human TrpV1
    Cat.:
    U12152h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human TrpV1
    MSDS:
    Please sign in first.
    CLIA Kit for Human TrpV1
    MSDS:
    Please sign in first.
    CLIA Kit for Human TrpV1
    Cat.:
    U12152r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TrpV1
    Cat.:
    U12152m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TrpV1
    Cat.:
    P12152Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TrpV1
    Polyclonal Antibody for Human TrpV1
    Polyclonal Antibody for Human TrpV1
    Polyclonal Antibody for Human TrpV1
    Monoclonal Antibody for Human TrpV1
    Monoclonal Antibody for Human TrpV1
    Monoclonal Antibody for Human TrpV1
    Monoclonal Antibody for Human TrpV1
    Monoclonal Antibody for Human TrpV1
    Protein for Human TrpV1
    Protein for Human TrpV1
    Protein for Human TrpV1
    Protein for Human TrpV1
    Protein for Human TrpV1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANTS ILE-315 AND VAL-585
    2. 2.
      "The tissue distribution and functional characterization of human VR1."
      Cortright D.N. , Crandall M. , Sanchez J.F. , Zou T. , Krause J.E. , White G.
      Biochem. Biophys. Res. Commun.281:1183-1189(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANTS SER-91; ILE-315 AND ILE-469
      tissue: Spinal ganglion.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;VARIANT ILE-315
      tissue: Spinal ganglion.
    4. 4.
      Lee D. , Ha I.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-315
      tissue: Brain.
    5. 5.
      "Isolation and characterization of a human TRPV1 splice variant."
      Lu L. , Mansson E.
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS ILE-315 AND VAL-585;ALTERNATIVE SPLICING
      tissue: Pancreas.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-315 AND ILE-469
      tissue: Testis.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ILE-315
    8. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-315
      tissue: Brain.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TRPV3
    10. 11.
      "Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures."
      Staender S. , Moormann C. , Schumacher M. , Buddenkotte J. , Artuc M. , Shpacovitch V. , Brzoska T. , Lippert U. , Henz B.M. , Luger T.A. , Metze D. , Steinhoff M.
      Exp. Dermatol.13:129-139(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-511 AND THR-550
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