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Index > Protein center > TXNRD1(Gene name) > Human
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  • TXNRD1 (Gene name),
  • Thioredoxin reductase 1, cytoplasmic (Protein name ),  TRXR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TXNRD1(GRIM12;KDRF);
    Protein name:
    Thioredoxin reductase 1, cytoplasmic(TR);
    Alternative:
    KM-102-derived reductase-like factor;Gene associated with retinoic and interferon-induced mortality 12 protein(GRIM-12;Gene associated with retinoic and IFN-induced mortality 12 protein);Thioredoxin reductase TR1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
    Function:
    Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
    Subcellular Location:
    Isoform 5 Cytoplasm
    Protein Attributes:
    Sequence length:
    649
    Sequence:
    50:
    MGCAEGKAVA | AAAPTELQTK | GKNGDGRRRS | AKDHHPGKTL | PENPAGFTST | 
    100:
    ATADSRALLQ | AYIDGHSVVI | FSRSTCTRCT | EVKKLFKSLC | VPYFVLELDQ | 
    150:
    TEDGRALEGT | LSELAAETDL | PVVFVKQRKI | GGHGPTLKAY | QEGRLQKLLK | 
    200:
    MNGPEDLPKS | YDYDLIIIGG | GSGGLAAAKE | AAQYGKKVMV | LDFVTPTPLG | 
    250:
    TRWGLGGTCV | NVGCIPKKLM | HQAALLGQAL | QDSRNYGWKV | EETVKHDWDR | 
    300:
    MIEAVQNHIG | SLNWGYRVAL | REKKVVYENA | YGQFIGPHRI | KATNNKGKEK | 
    350:
    IYSAERFLIA | TGERPRYLGI | PGDKEYCISS | DDLFSLPYCP | GKTLVVGASY | 
    400:
    VALECAGFLA | GIGLDVTVMV | RSILLRGFDQ | DMANKIGEHM | EEHGIKFIRQ | 
    450:
    FVPIKVEQIE | AGTPGRLRVV | AQSTNSEEII | EGEYNTVMLA | IGRDACTRKI | 
    500:
    GLETVGVKIN | EKTGKIPVTD | EEQTNVPYIY | AIGDILEDKV | ELTPVAIQAG | 
    550:
    RLLAQRLYAG | STVKCDYENV | PTTVFTPLEY | GACGLSEEKA | VEKFGEENIE | 
    600:
    VYHSYFWPLE | WTIPSRDNNK | CYAKIICNTK | DNERVVGFHV | LGPNAGEVTQ | 
    649:
    GFAAALKCGL | TKKQLDSTIG | IHPVCAEVFT | TLSVTKRSGA | SILQAGCUG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human TR
    Cat.:
    E1507h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TR
    Cat.:
    E1507m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TR
    Cat.:
    E1507r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TR
    Cat.:
    E1507p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TR
    Cat.:
    E1507b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TR
    Cat.:
    U1507b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TR
    Cat.:
    U1507h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TR
    Cat.:
    U1507r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TR
    Cat.:
    U1507p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TR
    Cat.:
    U1507m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TR
    Polyclonal Antibody for Human TR
    Polyclonal Antibody for Human TR
    Cat.:
    P1507Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TR
    Cat.:
    P1507Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TR
    Cat.:
    P1507Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TR
    Monoclonal Antibody for Human TR
    Monoclonal Antibody for Human TR
    Monoclonal Antibody for Human TR
    Monoclonal Antibody for Human TR
    Protein for Human TR
    Protein for Human TR
    Protein for Human TR
    Protein for Human TR
    Protein for Human TR

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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of a human thioredoxin reductase."
      Gasdaska P.Y. , Gasdaska J.R. , Cochran S. , Powis G.
      FEBS Lett.373:5-9(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);PROTEIN SEQUENCE OF 153-161; 307-315 AND 585-607;VARIANT GLY-365
      tissue: Placenta.
    2. 2.
      "Cloning and characterization of a novel oxidoreductase KDRF from a human bone marrow-derived stromal cell line KM-102."
      Koishi R. , Kawashima I. , Yoshimura C. , Sugawara M. , Serizawa N.
      J. Biol. Chem.272:2570-2577(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);PROTEIN SEQUENCE OF 122-127 AND 147-151;TISSUE SPECIFICITY
      tissue: Bone marrow stroma.
    3. 3.
      "Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid."
      Hofman E.R. , Boyanapalli M. , Lindner D.J. , Weihua X. , Hassel B.A. , Jagus R. , Gutierrez P.L. , Kalvakolanu D.V.
      Mol. Cell. Biol.18:6493-6504(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);FUNCTION;INDUCTION
      tissue: Mammary carcinoma.
    4. 4.
      "Evidence for intriguingly complex transcription of human thioredoxin reductase 1."
      Rundloef A.-K. , Janard M. , Miranda-Vizuete A. , Arner E.S.
      Free Radic. Biol. Med.36:641-656(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5);VARIANT GLY-365
      tissue: Mammary gland.
      tissue: Ovary.
      tissue: Testis.
      tissue: Thymus.
    5. 5.
      "Identification by ddPCR of thioredoxin reductase as a vitamin D regulated gene in human osteoblasts."
      Schuetze N. , Bachthaler M. , Lechner A. , Koehrle J. , Jakob F.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    6. 6.
      "Cloning and sequencing of thioredoxin reductase gene from human brain."
      Xu L. , Dai R. , Xu J.Y.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
      tissue: Brain.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Astrocyte.
      tissue: Thalamus.
      tissue: Trachea.
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    10. 10.
      NIEHS SNPs program
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    11. 11.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];IDENTIFICATION
      tissue: Trachea.
    13. 13.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Lung.
    14. 14.
      "Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene."
      Gladyshev V.N. , Jeang K.-T. , Stadtman T.C.
      Proc. Natl. Acad. Sci. U.S.A.93:6146-6151(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 307-316; 449-456; 466-476 AND 638-649;BLOCKAGE OF N-TERMINUS;SELENOCYSTEINE AT SEC-648;IDENTIFICATION BY MASS SPECTROMETRY
    15. 15.
      "A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity."
      Tamura T. , Stadtman T.C.
      Proc. Natl. Acad. Sci. U.S.A.93:1006-1011(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HOMODIMERIZATION;CHARACTERIZATION;PRESENCE OF SELENOCYSTEINE
    16. 16.
      "Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1."
      Su D. , Gladyshev V.N.
      Biochemistry43:12177-12188(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6);DOMAIN
    17. 17.
      "An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."
      Damdimopoulos A.E. , Miranda-Vizuete A. , Treuter E. , Gustafsson J.-A. , Spyrou G.
      J. Biol. Chem.279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ESR1 AND ESR2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY (ISOFORM 4)
    18. 18.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-281;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets."
      Wong J.J. , Pung Y.F. , Sze N.S. , Chin K.C.
      Proc. Natl. Acad. Sci. U.S.A.103:10735-10740(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERC5;ISGYLATION
    20. 20.
      "Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1."
      Dammeyer P. , Damdimopoulos A.E. , Nordman T. , Jimenez A. , Miranda-Vizuete A. , Arner E.S.J.
      J. Biol. Chem.283:2814-2821(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION (ISOFORM 1)
    21. 21.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis."
      Fritz-Wolf K. , Urig S. , Becker K.
      J. Mol. Biol.370:116-127(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) (ISOFORM 5)
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