Gene name:
TXNRD1 (GRIM12;KDRF) ;
Protein name:
Thioredoxin reductase 1, cytoplasmic (TR) ;
Alternative:
KM-102-derived reductase-like factor ;Gene associated with retinoic and interferon-induced mortality 12 protein (GRIM-12;Gene associated with retinoic and IFN-induced mortality 12 protein) ;Thioredoxin reductase TR1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
Function:
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Subcellular Location:
Isoform 5
Cytoplasm
Protein Attributes:
50:
MGCAEGKAVA | AAAPTELQTK | GKNGDGRRRS | AKDHHPGKTL | PENPAGFTST |
100:
ATADSRALLQ | AYIDGHSVVI | FSRSTCTRCT | EVKKLFKSLC | VPYFVLELDQ |
150:
TEDGRALEGT | LSELAAETDL | PVVFVKQRKI | GGHGPTLKAY | QEGRLQKLLK |
200:
MNGPEDLPKS | YDYDLIIIGG | GSGGLAAAKE | AAQYGKKVMV | LDFVTPTPLG |
250:
TRWGLGGTCV | NVGCIPKKLM | HQAALLGQAL | QDSRNYGWKV | EETVKHDWDR |
300:
MIEAVQNHIG | SLNWGYRVAL | REKKVVYENA | YGQFIGPHRI | KATNNKGKEK |
350:
IYSAERFLIA | TGERPRYLGI | PGDKEYCISS | DDLFSLPYCP | GKTLVVGASY |
400:
VALECAGFLA | GIGLDVTVMV | RSILLRGFDQ | DMANKIGEHM | EEHGIKFIRQ |
450:
FVPIKVEQIE | AGTPGRLRVV | AQSTNSEEII | EGEYNTVMLA | IGRDACTRKI |
500:
GLETVGVKIN | EKTGKIPVTD | EEQTNVPYIY | AIGDILEDKV | ELTPVAIQAG |
550:
RLLAQRLYAG | STVKCDYENV | PTTVFTPLEY | GACGLSEEKA | VEKFGEENIE |
600:
VYHSYFWPLE | WTIPSRDNNK | CYAKIICNTK | DNERVVGFHV | LGPNAGEVTQ |
649:
GFAAALKCGL | TKKQLDSTIG | IHPVCAEVFT | TLSVTKRSGA | SILQAGCUG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);PROTEIN SEQUENCE OF 153-161; 307-315 AND 585-607;VARIANT GLY-365
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Astrocyte .
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Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Nature440:346-351(2006)
[
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[
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[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];IDENTIFICATION
tissue :
Trachea .
13.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue :
Lung .
14.
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Cited for : PROTEIN SEQUENCE OF 307-316; 449-456; 466-476 AND 638-649;BLOCKAGE OF N-TERMINUS;SELENOCYSTEINE AT SEC-648;IDENTIFICATION BY MASS SPECTROMETRY
15.
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Cited for : FUNCTION;HOMODIMERIZATION;CHARACTERIZATION;PRESENCE OF SELENOCYSTEINE
16.
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Cited for : ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6);DOMAIN
17.
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Cited for : FUNCTION;INTERACTION WITH ESR1 AND ESR2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY (ISOFORM 4)
18.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-281;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
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Cited for : INTERACTION WITH HERC5;ISGYLATION
20.
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Cited for : FUNCTION;TISSUE SPECIFICITY;INDUCTION (ISOFORM 1)
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) (ISOFORM 5)