Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > PRSS1(Gene name) > Human
  • Add your favorite
  • PRSS1 (Gene name),
  • Trypsin-1 (Protein name ),  TRY1_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    PRSS1(TRP1;TRY1;TRYP1);
    Protein name:
    Trypsin-1;
    Alternative:
    Trypsin I;Serine protease 1;Beta-trypsin;Cationic trypsinogen;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    247
    Sequence:
    50:
    MNPLLILTFV | AAALAAPFDD | DDKIVGGYNC | EENSVPYQVS | LNSGYHFCGG | 
    100:
    SLINEQWVVS | AGHCYKSRIQ | VRLGEHNIEV | LEGNEQFINA | AKIIRHPQYD | 
    150:
    RKTLNNDIML | IKLSSRAVIN | ARVSTISLPT | APPATGTKCL | ISGWGNTASS | 
    200:
    GADYPDELQC | LDAPVLSQAK | CEASYPGKIT | SNMFCVGFLE | GGKDSCQGDS | 
    247:
    GGPVVCNGQL | QGVVSWGDGC | AQKNKPGVYT | KVYNYVKWIK | NTIAANS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Trypsin-1
    Cat.:
    E1830r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Trypsin-1
    Cat.:
    E1830h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Trypsin-1
    Cat.:
    U1830h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Trypsin-1
    Cat.:
    U1830r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Trypsin-1
    Cat.:
    P1830Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Trypsin-1
    Cat.:
    P1830Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Trypsin-1
    Monoclonal Antibody for Human Trypsin-1
    Protein for Human Trypsin-1
    Protein for Human Trypsin-1

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens."
      Emi M. , Nakamura Y. , Ogawa M. , Yamamoto T. , Nishide T. , Mori T. , Matsubara K.
      Gene41:305-310(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
      Rowen L. , Koop B.F. , Hood L.
      Science272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    4. 4.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 8.
      "Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation."
      Teich N. , Ockenga J. , Hoffmeister A. , Manns M. , Mossner J. , Keim V.
      Gastroenterology119:461-465(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-67;VARIANT PCTT GLY-22
    8. 9.
      "Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line."
      Koshikawa N. , Yasumitsu H. , Nagashima Y. , Umeda M. , Miyazaki K.
      Biochem. J.303:187-190(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-43 AND 123-142;FUNCTION;POST-TRANSLATIONAL PROCESSING
      tissue: Gastric adenocarcinoma.
    9. 10.
      "Immunoreactive anionic and cationic trypsin in human serum."
      Kimland M. , Russick C. , Marks W.H. , Borgstroem A.
      Clin. Chim. Acta184:31-46(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-43
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-151;VARIANT PCTT HIS-122
    11. 12.
      "Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants."
      Teich N. , Bauer N. , Mossner J. , Keim V.
      Am. J. Gastroenterol.97:341-346(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-151;VARIANTS PCTT ILE-29; PRO-104; CYS-116; HIS-122 AND PHE-139
    12. 13.
      Lubec G. , Afjehi-Sadat L.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 73-92;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
    13. 14.
      "Human cationic trypsinogen is sulfated on Tyr154."
      Sahin-Toth M. , Kukor Z. , Nemoda Z.
      FEBS J.273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-154;MUTAGENESIS OF TYR-154
    14. 15.
      "Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids."
      Szabo A. , Salameh M.A. , Ludwig M. , Radisky E.S. , Sahin-Toth M.
      PLoS ONE9:E102063-E102063(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-154
    15. 16.
      "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151."
      Gaboriaud C. , Serre L. , Guy-Crotte O. , Forest E. , Fontecilla-Camps J.-C.
      J. Mol. Biol.259:995-1010(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS);MASS SPECTROMETRY
    16. 17.
      "Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis."
      Gorry M.C. , Gabbaizedeh D. , Furey W. , Gates L.K. Jr. , Preston R.A. , Aston C.E. , Zhang Y. , Ulrich C. , Ehrlich G.D. , Whitcomb D.C.
      Gastroenterology113:1063-1068(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCTT ILE-29 AND HIS-122
    17. 18.
      "Mutations of the cationic trypsinogen in hereditary pancreatitis."
      Teich N. , Mossner J. , Keim V.
      Hum. Mutat.12:39-43(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCTT ILE-29
    18. 19.
      "A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis."
      Witt H. , Luck W. , Becker M.
      Gastroenterology117:7-10(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCTT VAL-16 AND HIS-122
    19. 20.
      "Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis."
      Ferec C. , Raguenes O. , Salomon R. , Roche C. , Bernard J.P. , Guillot M. , Quere I. , Faure C. , Mercier B. , Audrezet M.-P. , Guillausseau P.J. , Dupont C. , Munnich A. , Bignon J.D. , Le Bodic L.
      J. Med. Genet.36:228-232(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCTT ARG-23
    20. 21.
      "A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis."
      Chen J.-M. , Raguenes O. , Ferec C. , Deprez P.H. , Verellen-Dumoulin C.
      J. Med. Genet.37:E36-E36(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCTT HIS-122
    21. 22.
      "Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis."
      Pfutzer R. , Myers E. , Applebaum-Shapiro S. , Finch R. , Ellis I. , Neoptolemos J. , Kant J.A. , Whitcomb D.C.
      Gut50:271-272(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCTT THR-29 AND CYS-122
    22. 23.
      "Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)."
      Teich N. , Le Marechal C. , Kukor Z. , Caca K. , Witzigmann H. , Chen J.-M. , Toth M. , Moessner J. , Keim V. , Ferec C. , Sahin-Toth M.
      Hum. Mutat.23:22-31(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCTT LYS-79;CHARACTERIZATION OF VARIANT PCTT LYS-79
    23. 24.
      "Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl."
      Teich N. , Nemoda Z. , Koehler H. , Heinritz W. , Moessner J. , Keim V. , Sahin-Toth M.
      Hum. Mutat.25:343-347(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCTT ILE-29 AND SER-54;CHARACTERIZATION OF VARIANTS PCTT ILE-29 AND SER-54
    24. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-137
    Product Feedback Wall
    Hot Genes
    ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
    Top Searches
    Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin TRAP1A Tumor necrosis vitamin d
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter