TPSAB1 ELISA Kit for Human(Homo sapiens) | EIAab.comTPSAB1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TPSAB1(Gene name) > Human

TPSAB1 (Gene name),

Tryptase alpha/beta-1 (Protein name ), TRYB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

TPSAB1(TPS1;TPS2;TPSB1);

Protein name:

Tryptase alpha/beta-1(Tryptase-1);

Alternative:

Tryptase alpha-1;Tryptase I;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

Function:

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

Subcellular Location:

Secreted Released from the secretory granules upon mast cell activation.

Protein Attributes:

Sequence length:

275

Sequence:

50:

100:

150:

200:

250:

275:

PNRPGIYTRV | TYYLDWIHHY | VPKKP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:7177

KEGG:

hsa:100507804

STRING:

9606.ENSP00000343577

UniGene:

Hs.405479

MIM:

191080

Pfam:

PF00089

SMR:

Q15661

String:

Q15661

Uniprot:

Q15661

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ELISA Kit for Human Tryptase-1

Cat.:

E1070h

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96T

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ELISA Kit for Human Tryptase-1

Cat.:

E1070r

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96T

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ELISA Kit for Human Tryptase-1

Cat.:

E1070m

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96T

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CLIA Kit for Human Tryptase-1

Cat.:

U1070r

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96T

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CLIA Kit for Human Tryptase-1

Cat.:

U1070h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Tryptase-1

Cat.:

U1070m

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Packing:

96T

Polyclonal Antibody for Human Tryptase-1

Cat.:

P1070Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tryptase-1

Cat.:

P1070Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Tryptase-1

Cat.:

P1070Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tryptase-1

Protein for Human Tryptase-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Circulating Tryptase as a Marker for Subclinical Atherosclerosis in Obese Subjects"

M Moreno, J Puig, M Serrano, et al.

From:PloS one

[2].

"Proposed EUTOS-T Prognostic Score Evaluation in Chronic Myeloid Leukemia and its Predictive Value"

A Youssef, M Elsorady, M Ayad, et al.

From:Clinical Lymphoma Myeloma and Leukemia

References

1.

"Cloning and characterization of complementary DNA for human tryptase."
Miller J.S. , Westin E.H. , Schwartz L.B.
J. Clin. Invest.84:1188-1195(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS THR-85; SER-215; GLN-216 AND LYS-221
tissue: Lung.
2.

Schwartz L.B.
Submitted (1990-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 89-93 AND 108
3.

"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."
Vanderslice P. , Ballinger S.M. , Tam E.K. , Goldstein S.M. , Craik C.S. , Caughey G.H.
Proc. Natl. Acad. Sci. U.S.A.87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE BETA-I) (ISOFORM 1)
4.

"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."
Pallaoro M. , Fejzo M.S. , Shayesteh L. , Blount J.L. , Caughey G.H.
J. Biol. Chem.274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES ALPHA AND BETA-I) (ISOFORM 1)
5.

"Molecular cloning and characterization of novel human tryptase cDNAs and splicing variants."
Wang H.W. , McNeil H.P. , Thomas P.S. , Murphy B.N. , Webster M.J. , Hettiaratchi A. , King G. , Heywood G.J. , Huang C. , Stevens R.L. , Hunt J.E.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 16-275 (ALLELE ALPHA; ISOFORM 2);NUCLEOTIDE SEQUENCE [MRNA] OF 54-275 (ALLELE BETA-I; ISOFORM 2);VARIANTS PRO-15 AND THR-85
6.

"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."
Trivedi N.N. , Tamraz B. , Chu C. , Kwok P.Y. , Caughey G.H.
J. Allergy Clin. Immunol.124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS PRO-15; SER-170; SER-215; GLN-216 AND LYS-221
7.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LYS-132
9.

"Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates."
Cromlish J.A. , Seidah N.G. , Marcinkiewcz M. , Hamelin J. , Johnson D.A. , Chretein M.
J. Biol. Chem.262:1363-1373(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-50;PROTEIN SEQUENCE OF 31-38
tissue: Lung.
10.

"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
Strik M.C. , Wolbink A. , Wouters D. , Bladergroen B.A. , Verlaan A.R. , van Houdt I.S. , Hijlkema S. , Hack C.E. , Kummer J.A.
Blood103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A COMPLEX WITH SERPINB6
11.

"Active monomers of human beta-tryptase have expanded substrate specificities."
Fukuoka Y. , Schwartz L.B.
Int. Immunopharmacol.7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-233
tissue: Liver.
13.

"The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region."
Marquardt U. , Zettl F. , Huber R. , Bode W. , Sommerhoff C.
J. Mol. Biol.321:491-502(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 31-275
14.

"Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog."
Guida M. , Riedy M. , Lee D. , Hall J.
Pharmacogenetics10:389-396(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-15; VAL-18; VAL-23; THR-85; LYS-132; ALA-141; ASN-162; SER-170; SER-215; GLN-216; LYS-221 AND ASN-263

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