TPSB2 ELISA Kit for Human(Homo sapiens) | EIAab.comTPSB2 ELISA Kit for Human(Homo sapiens)

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TPSB2 (Gene name),

Tryptase beta-2 (Protein name ), TRYB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TPSB2(TPS2);

Protein name:

Tryptase beta-2(Tryptase-2);

Alternative:

Tryptase II;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

Function:

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection.

Subcellular Location:

Secreted Released from the secretory granules upon mast cell activation.

Protein Attributes:

Sequence length:

275

Sequence:

50:

100:

150:

200:

250:

275:

PNRPGIYTRV | TYYLDWIHHY | VPKKP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.405479

MIM:

191081

SMR:

P20231

KEGG:

hsa:64499

Pfam:

PF00089

String:

P20231

STRING:

9606.ENSP00000420825

Uniprot:

P20231

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ELISA Kit for Human Tryptase-2

Cat.:

E0258h

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96T

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ELISA Kit for Human Tryptase-2

Cat.:

E0258m

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96T

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ELISA Kit for Human Tryptase-2

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E0258r

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96T

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CLIA Kit for Human Tryptase-2

Cat.:

U0258m

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96T

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CLIA Kit for Human Tryptase-2

Cat.:

U0258h

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96T

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CLIA Kit for Human Tryptase-2

Cat.:

U0258r

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Packing:

96T

Polyclonal Antibody for Human Tryptase-2

Cat.:

P0258Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tryptase-2

Cat.:

P0258Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Tryptase-2

Cat.:

P0258Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Tryptase-2

Protein for Human Tryptase-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and characterization of a second complementary DNA for human tryptase."
Miller J.S. , Moxley G. , Schwartz L.B.
J. Clin. Invest.86:864-870(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (VARIANT BETA-2)
tissue: Lung.
2.

"Characterization of a tryptase mRNA expressed in the human basophil cell line KU812."
Blom T. , Hellman L.
Scand. J. Immunol.37:203-208(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (VARIANT BETA-2)
3.

"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."
Pallaoro M. , Fejzo M.S. , Shayesteh L. , Blount J.L. , Caughey G.H.
J. Biol. Chem.274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANTS BETA-2 AND BETA-3)
4.

Pallaoro M. , Fejzo M.S. , Shayesteh L. , Blount J.L. , Caughey G.H.
Submitted (2001-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
5.

"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."
Trivedi N.N. , Tamraz B. , Chu C. , Kwok P.Y. , Caughey G.H.
J. Allergy Clin. Immunol.124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANT BETA-2);NUCLEOTIDE SEQUENCE [MRNA] OF 50-275 (VARIANT BETA-3)
6.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (VARIANT BETA-2)
tissue: Lung.
8.

"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."
Vanderslice P. , Ballinger S.M. , Tam E.K. , Goldstein S.M. , Craik C.S. , Caughey G.H.
Proc. Natl. Acad. Sci. U.S.A.87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-275 (VARIANT BETA-2);NUCLEOTIDE SEQUENCE [MRNA] OF 9-275 (VARIANT BETA-3)
9.

"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
Strik M.C. , Wolbink A. , Wouters D. , Bladergroen B.A. , Verlaan A.R. , van Houdt I.S. , Hijlkema S. , Hack C.E. , Kummer J.A.
Blood103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A COMPLEX WITH SERPINB6
10.

"Active monomers of human beta-tryptase have expanded substrate specificities."
Fukuoka Y. , Schwartz L.B.
Int. Immunopharmacol.7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
11.

"Human beta-tryptase is a ring-like tetramer with active sites facing a central pore."
Pereira P.J.B. , Bergner A. , Macedo-Ribeiro S. , Huber R. , Matschiner G. , Fritz H. , Sommerhoff C.P. , Bode W.
Nature392:306-311(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
12.

"The structure of the human betaII-tryptase tetramer: fo(u)r better or worse."
Sommerhoff C.P. , Bode W. , Pereira P.J.B. , Stubbs M.T. , Stuerzebecher J. , Piechottka G.P. , Matschiner G. , Bergner A.
Proc. Natl. Acad. Sci. U.S.A.96:10984-10991(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS)

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