Protein name:
Thrombospondin-1 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homotrimer; disulfide-linked (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Binds heparin. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36.
Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties.
Subcellular Location:
N/A
Protein Attributes:
50:
MELLRGLGVL | FLLHMCGSNR | IPESGGDNGV | FDIFELIGGA | RRGPGRRLVK |
100:
GQDLSSPAFR | IENANLIPAV | PDDKFQDLLD | AVWADKGFIF | LASLRQMKKT |
150:
RGTLLAVERK | DNTGQIFSVV | SNGKAGTLDL | SLSLPGKQQV | VSVEEALLAT |
200:
GQWKSITLFV | QEDRAQLYID | CDKMESAELD | VPIQSIFTRD | LASVARLRVA |
250:
KGDVNDNFQG | VLQNVRFVFG | TTPEDILRNK | GCSSSTNVLL | TLDNNVVNGS |
300:
SPAIRTNYIG | HKTKDLQAIC | GLSCDELSSM | VLELKGLRTI | VTTLQDSIRK |
350:
VTEENRELVS | ELKRPPLCFH | NGVQYKNNEE | WTVDSCTECH | CQNSVTICKK |
400:
VSCPIMPCSN | ATVPDGECCP | RCWPSDSADD | GWSPWSEWTS | CSATCGNGIQ |
450:
QRGRSCDSLN | NRCEGSSVQT | RTCHIQECDK | RFKQDGGWSH | WSPWSSCSVT |
500:
CGDGVITRIR | LCNSPSPQMN | GKPCEGEARE | TKACKKDACP | INGGWGPWSP |
550:
WDICSVTCGG | GVQRRSRLCN | NPTPQFGGKD | CVGDVTENQV | CNKQDCPIDG |
600:
CLSNPCFAGA | KCTSYPDGSW | KCGACPPGYS | GNGIQCKDVD | ECKEVPDACF |
650:
NHNGEHRCKN | TDPGYNCLPC | PPRFTGSQPF | GRGVEHAMAN | KQVCKPRNPC |
700:
TDGTHDCNKN | AKCNYLGHYS | DPMYRCECKP | GYAGNGIICG | EDTDLDGWPN |
750:
ENLVCVANAT | YHCKKDNCPN | LPNSGQEDYD | KDGIGDACDD | DDDNDKIPDD |
800:
RDNCPFHYNP | AQYDYDRDDV | GDRCDNCPYN | HNPDQADTDK | NGEGDACAVD |
850:
IDGDGILNER | DNCQYVYNVD | QRDTDMDGVG | DQCDNCPLEH | NPDQLDSDSD |
900:
LIGDTCDNNQ | DIDEDGHQNN | LDNCPYVPNA | NQADHDKDGK | GDACDHDDDN |
950:
DGIPDDRDNC | RLVPNPDQKD | SDGDGRGDAC | KDDFDHDNVP | DIDDICPENF |
1000:
DISETDFRRF | QMIPLDPKGT | SQNDPNWVVR | HQGKELVQTV | NCDPGLAVGY |
1050:
DEFNAVDFSG | TFFINTERDD | DYAGFVFGYQ | SSSRFYVVMW | KQVTQSYWDT |
1100:
NPTRAQGYSG | LSVKVVNSTT | GPGEHLRNAL | WHTGNTPGQV | RTLWHDPRHI |
1150:
GWKDFTAYRW | RLSHRPKTGY | IRVVMYEGKK | IMADSGPIYD | KTYAGGRLGL |
1170:
FVFSQEMVFF | SDMKYECRDS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Mouse Thrombospondin-1
ELISA Kit for Mouse Thrombospondin-1
ELISA Kit for Mouse Thrombospondin-1
CLIA Kit for Mouse Thrombospondin-1
CLIA Kit for Mouse Thrombospondin-1
CLIA Kit for Mouse Thrombospondin-1
Polyclonal Antibody for Mouse Thrombospondin-1
Polyclonal Antibody for Mouse Thrombospondin-1
Polyclonal Antibody for Mouse Thrombospondin-1
Monoclonal Antibody for Mouse Thrombospondin-1
Monoclonal Antibody for Mouse Thrombospondin-1
Monoclonal Antibody for Mouse Thrombospondin-1
Protein for Mouse Thrombospondin-1
Protein for Mouse Thrombospondin-1
Protein for Mouse Thrombospondin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-490
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 19-37
5.
"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L.
,
Raginski K.
,
Tarasova Y.
,
Tchernyshyov I.
,
Bausch-Fluck D.
,
Elliott S.T.
,
Boheler K.R.
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Van Eyk J.E.
,
Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1067
tissue :
Myoblast .
6.
"A thrombospondin-dependent pathway for a protective ER stress response."
Lynch J.M.
,
Maillet M.
,
Vanhoutte D.
,
Schloemer A.
,
Sargent M.A.
,
Blair N.S.
,
Lynch K.A.
,
Okada T.
,
Aronow B.J.
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Osinska H.
,
Prywes R.
,
Lorenz J.N.
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Mori K.
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Lawler J.
,
Robbins J.
,
Molkentin J.D.
Cell149:1257-1268(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ATF6