TYK2 ELISA Kit for Human(Homo sapiens) | EIAab.comTYK2 ELISA Kit for Human(Homo sapiens)

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TYK2 (Gene name),

Non-receptor tyrosine-protein kinase TYK2 (Protein name ), TYK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TYK2;

Protein name:

Non-receptor tyrosine-protein kinase TYK2;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with JAKMIP1.

Function:

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Subcellular Location:

Protein Attributes:

Sequence length:

1187

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1187:

CWETEASFRP | TFENLIPILK | TVHEKYQGQA | PSVFSVC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.75516

String:

P29597

MIM:

176941

Pfam:

PF07714

SMR:

P29597

KEGG:

hsa:7297

STRING:

9606.ENSP00000264818

Uniprot:

P29597

FOR

ELISA Kit for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

E1595h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

E1595m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

U1595h

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MSDS:

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Packing:

96T

CLIA Kit for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

U1595m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

P1595Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Non-receptor tyrosine-protein kinase TYK2

Cat.:

P1595Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Non-receptor tyrosine-protein kinase TYK2

Protein for Human Non-receptor tyrosine-protein kinase TYK2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"TYK2, prototype of a novel class of non-receptor tyrosine kinase genes."
Firmbach-Kraft I. , Byers M. , Shows T. , Dalla-Favera R. , Krolewski J.J.
Oncogene5:1329-1336(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PHE-362 AND SER-684
2.

SeattleSNPs variation discovery resource
Submitted (2004-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-4; HIS-197; PHE-362; SER-363 AND SER-684
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
4.

"A protein tyrosine kinase in the interferon alpha/beta signaling pathway."
Velazquez L. , Fellous M. , Stark G.R. , Pellegrini S.
Cell70:313-322(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-1187
5.

"Identification and chromosomal mapping of new human tyrosine kinase genes."
Krolewski J.J. , Lee R. , Eddy R. , Shows T.B. , Dalla-Favera R.
Oncogene5:277-282(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1007-1162;TISSUE SPECIFICITY
6.

"Putative tyrosine kinases expressed in K-562 human leukemia cells."
Partanen J. , Maekelae T.P. , Alitalo R. , Lehvaeslaiho H. , Alitalo K.
Proc. Natl. Acad. Sci. U.S.A.87:8913-8917(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1025-1082
7.

"Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
Colamonici O. , Yan H. , Domanski P. , Handa R. , Smalley D. , Mullersman J. , Witte M. , Krishnan K. , Krolewski J.
Mol. Cell. Biol.14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF IFNAR1
8.

"Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules."
Steindler C. , Li Z. , Algarte M. , Alcover A. , Libri V. , Ragimbeau J. , Pellegrini S.
J. Biol. Chem.279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1
9.

"Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity."
Minegishi Y. , Saito M. , Morio T. , Watanabe K. , Agematsu K. , Tsuchiya S. , Takada H. , Hara T. , Kawamura N. , Ariga T. , Kaneko H. , Kondo N. , Tsuge I. , Yachie A. , Sakiyama Y. , Iwata T. , Bessho F. , Ohishi T. , more...
Immunity25:745-755(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD35
10.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6."
Chrencik J.E. , Patny A. , Leung I.K. , Korniski B. , Emmons T.L. , Hall T. , Weinberg R.A. , Gormley J.A. , Williams J.M. , Day J.E. , Hirsch J.L. , Kiefer J.R. , Leone J.W. , Fischer H.D. , Sommers C.D. , Huang H.C. , Jacobsen E.J. , Tenbrink R.E. , more...
J. Mol. Biol.400:413-433(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 888-1182 IN COMPLEX WITH INHIBITOR;PHOSPHORYLATION AT TYR-1054
13.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-362; SER-363; MET-386; SER-684; TRP-703; ARG-732; VAL-928; ALA-1104 AND GLY-1163

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