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Index > Protein center > DCT(Gene name) > Human
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  • DCT (Gene name),
  • L-dopachrome tautomerase (Protein name ),  TYRP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DCT(TYRP2);
    Protein name:
    L-dopachrome tautomerase(DCT;DT);
    Alternative:
    Tyrosinase-related protein 2(TRP-2;TRP2);L-dopachrome Delta-isomerase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.
    Function:
    Involved in regulating eumelanin and phaeomelanin levels.
    Subcellular Location:
    Melanosome membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    519
    Sequence:
    50:
    MSPLWWGFLL | SCLGCKILPG | AQGQFPRVCM | TVDSLVNKEC | CPRLGAESAN | 
    100:
    VCGSQQGRGQ | CTEVRADTRP | WSGPYILRNQ | DDRELWPRKF | FHRTCKCTGN | 
    150:
    FAGYNCGDCK | FGWTGPNCER | KKPPVIRQNI | HSLSPQEREQ | FLGALDLAKK | 
    200:
    RVHPDYVITT | QHWLGLLGPN | GTQPQFANCS | VYDFFVWLHY | YSVRDTLLGP | 
    250:
    GRPYRAIDFS | HQGPAFVTWH | RYHLLCLERD | LQRLIGNESF | ALPYWNFATG | 
    300:
    RNECDVCTDQ | LFGAARPDDP | TLISRNSRFS | SWETVCDSLD | DYNHLVTLCN | 
    350:
    GTYEGLLRRN | QMGRNSMKLP | TLKDIRDCLS | LQKFDNPPFF | QNSTFSFRNA | 
    400:
    LEGFDKADGT | LDSQVMSLHN | LVHSFLNGTN | ALPHSAANDP | IFVVLHSFTD | 
    450:
    AIFDEWMKRF | NPPADAWPQE | LAPIGHNRMY | NMVPFFPPVT | NEELFLTSDQ | 
    500:
    LGYSYAIDLP | VSVEETPGWP | TTLLVVMGTL | VALVGLFVLL | AFLQYRRLRK | 
    519:
    GYTPLMETHL | SSKRYTEEA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    MIM:
    String:
    Uniprot:
     
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    ELISA Kit for Human DCT
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    ELISA Kit for Human DCT
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    ELISA Kit for Human DCT
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    CLIA Kit for Human DCT
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    CLIA Kit for Human DCT
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    U1154h
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    CLIA Kit for Human DCT
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    U1154c
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    Polyclonal Antibody for Human DCT
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    P1154Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DCT
    Polyclonal Antibody for Human DCT
    Polyclonal Antibody for Human DCT
    Polyclonal Antibody for Human DCT
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    P1154Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DCT
    Monoclonal Antibody for Human DCT
    Monoclonal Antibody for Human DCT
    Monoclonal Antibody for Human DCT
    Monoclonal Antibody for Human DCT
    Protein for Human DCT
    Protein for Human DCT
    Protein for Human DCT
    Protein for Human DCT
    Protein for Human DCT

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    References
    1. 1.
      "Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2."
      Yokoyama K. , Suzuki H. , Yasumoto K.I. , Tomita Y. , Shibahara S.
      Biochim. Biophys. Acta1217:317-321(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA."
      Cassady J.L. , Sturm R.A.
      Gene143:295-298(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells."
      Bouchard B. , del Marmol V. , Jackson I.J. , Cherif D. , Dubertret L.
      Eur. J. Biochem.219:127-134(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy."
      Khong H.T. , Rosenberg S.A.
      J. Immunol.168:951-956(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
      tissue: Melanoma.
    5. 5.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary gland.
    7. 7.
      "Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family."
      Sturm R.A. , O'Sullivan B.J. , Box N.F. , Smith A.G. , Smit S.E. , Puttick E.R.J. , Parsons P.G. , Dunn I.S.
      Genomics29:24-34(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98
      tissue: Liver.
    8. 8.
      "Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression."
      Yokoyama K. , Yasumoto K.I. , Suzuki H. , Shibahara S.
      J. Biol. Chem.269:27080-27087(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98
      tissue: Liver.
    9. 9.
      "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
      Basrur V. , Yang F. , Kushimoto T. , Higashimoto Y. , Yasumoto K. , Valencia J. , Muller J. , Vieira W.D. , Watabe H. , Shabanowitz J. , Hearing V.J. , Hunt D.F. , Appella E.
      J. Proteome Res.2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    10. 10.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
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