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Index > Protein center > UACA(Gene name) > Human
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  • UACA (Gene name),
  • Uveal autoantigen with coiled-coil domains and ankyrin repeats (Protein name ),  UACA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    UACA(KIAA1561);
    Protein name:
    Uveal autoantigen with coiled-coil domains and ankyrin repeats;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB.
    Function:
    Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury.
    Subcellular Location:
    Nucleus Cytoplasm Cytoplasm cytoskeleton Expressed diffusely in cytoplasm.
    Protein Attributes:
    Sequence length:
    1416
    Sequence:
    50:
    MKSLKSRLRR | QDVPGPASSG | AAAASAHAAD | WNKYDDRLMK | AAERGDVEKV | 
    100:
    TSILAKKGVN | PGKLDVEGRS | VFHVVTSKGN | LECLNAILIH | GVDITTSDTA | 
    150:
    GRNALHLAAK | YGHALCLQKL | LQYNCPTEHA | DLQGRTALHD | AAMADCPSSI | 
    200:
    QLLCDHGASV | NAKDVDGRTP | LVLATQMSRP | TICQLLIDRG | ADVNSRDKQN | 
    250:
    RTALMLGCEY | GCRDAVEVLI | KNGADISLLD | ALGHDSSYYA | RIGDNLDILT | 
    300:
    LLKTASENTN | KGRELWKKGP | SLQQRNLTHM | QDEVNVKSHQ | REHQNIQDLE | 
    350:
    IENEDLKERL | RKIQQEQRIL | LDKVNGLQLQ | LNEEVMVADD | LESEREKLKS | 
    400:
    LLAAKEKQHE | ESLRTIEALK | NRFKYFESDH | LGSGSHFSNR | KEDMLLKQGQ | 
    450:
    MYMADSQCTS | PGIPAHMQSR | SMLRPLELSL | PSQTSYSENE | ILKKELEAMR | 
    500:
    TFCESAKQDR | LKLQNELAHK | VAECKALALE | CERVKEDSDE | QIKQLEDALK | 
    550:
    DVQKRMYESE | GKVKQMQTHF | LALKEHLTSE | AASGNHRLTE | ELKDQLKDLK | 
    600:
    VKYEGASAEV | GKLRNQIKQN | EMIVEEFKRD | EGKLIEENKR | LQKELSMCEM | 
    650:
    EREKKGRKVT | EMEGQAKELS | AKLALSIPAE | KFENMKSSLS | NEVNEKAKKL | 
    700:
    VEMEREHEKS | LSEIRQLKRE | LENVKAKLAQ | HVKPEEHEQV | KSRLEQKSGE | 
    750:
    LGKKITELTL | KNQTLQKEIE | KVYLDNKLLK | EQAHNLTIEM | KNHYVPLKVS | 
    800:
    EDMKKSHDAI | IDDLNRKLLD | VTQKYTEKKL | EMEKLLLEND | SLSKDVSRLE | 
    850:
    TVFVPPEKHE | KEIIALKSNI | VELKKQLSEL | KKKCGEDQEK | IHALTSENTN | 
    900:
    LKKMMSNQYV | PVKTHEEVKM | TLNDTLAKTN | RELLDVKKKF | EDINQEFVKI | 
    950:
    KDKNEILKRN | LENTQNQIKA | EYISLAEHEA | KMSSLSQSMR | KVQDSNAEIL | 
    1000:
    ANYRKGQEEI | VTLHAEIKAQ | KKELDTIQEC | IKVKYAPIVS | FEECERKFKA | 
    1050:
    TEKELKDQLS | EQTQKYSVSE | EEVKKNKQEN | DKLKKEIFTL | QKDLRDKTVL | 
    1100:
    IEKSHEMERA | LSRKTDELNK | QLKDLSQKYT | EVKNVKEKLV | EENAKQTSEI | 
    1150:
    LAVQNLLQKQ | HVPLEQVEAL | KKSLNGTIEN | LKEELKSMQR | CYEKEQQTVT | 
    1200:
    KLHQLLENQK | NSSVPLAEHL | QIKEAFEKEV | GIIKASLREK | EEESQNKMEE | 
    1250:
    VSKLQSEVQN | TKQALKKLET | REVVDLSKYK | ATKSDLETQI | SSLNEKLANL | 
    1300:
    NRKYEEVCEE | VLHAKKKEIS | AKDEKELLHF | SIEQEIKDQK | ERCDKSLTTI | 
    1350:
    TELQRRIQES | AKQIEAKDNK | ITELLNDVER | LKQALNGLSQ | LTYTSGNPTK | 
    1400:
    RQSQLIDTLQ | HQVKSLEQQL | ADADRQHQEV | IAIYRTHLLS | AAQGHMDEDV | 
    1416:
    QEALLQIIQM | RQGLVC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    E3054h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    E3054m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    MSDS:
    Please sign in first.
    ELISA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    E3054b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    MSDS:
    Please sign in first.
    CLIA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    U3054m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    U3054h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    U3054b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    P3054Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Polyclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Cat.:
    P3054Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Monoclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Monoclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Monoclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Monoclonal Antibody for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Protein for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Protein for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Protein for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Protein for Human Uveal autoantigen with coiled-coil domains and ankyrin repeats

    R&D Technical Data

    s

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    s
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤5.8%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.9%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of UACA into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    98

    91-104

    Plasma

    99

    92-105

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of UACA and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    91-107%

    93-103%

    94-101%

    92-105%

    EDTA plasma(n=5)

    90-110%

    92-105%

    95-103%

    94-104%

    heparin plasma(n=5)

    93-104%

     

    94-106%

    92-108%

    91-109%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification of a novel autoantigen UACA in patients with panuveitis."
      Yamada K. , Senju S. , Nakatsura T. , Murata Y. , Ishihara M. , Nakamura S. , Ohno S. , Negi A. , Nishimura Y.
      Biochem. Biophys. Res. Commun.280:1169-1176(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1187 (ISOFORM 1/2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 2)
      tissue: Brain.
      tissue: Embryo.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1181-1416 (ISOFORM 1/2)
      tissue: Brain.
    8. 9.
      "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease."
      Ohkura T. , Taniguchi S. , Yamada K. , Nishio N. , Okamura T. , Yoshida A. , Kamijou K. , Fukata S. , Kuma K. , Inoue Y. , Hisatome I. , Senju S. , Nishimura Y. , Shigemasa C.
      Biochem. Biophys. Res. Commun.321:432-440(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INDUCTION
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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