UBD ELISA Kit for Human(Homo sapiens) | EIAab.comUBD ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UBD(Gene name) > Human

UBD (Gene name),

Ubiquitin D (Protein name ), UBD_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBD(FAT10);

Protein name:

Ubiquitin D;

Alternative:

Ubiquitin-like protein FAT10;Diubiquitin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).

Function:

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

Subcellular Location:

Nucleus Cytoplasm Accumulates in aggresomes under proteasome inhibition conditions.

Protein Attributes:

Sequence length:

165

Sequence:

50:

100:

150:

165:

RKGNLLFLAC | YCIGG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O15205

UniGene:

Hs.44532

String:

O15205

MIM:

606050

KEGG:

hsa:10537

UniGene:

Hs.728313

STRING:

9606.ENSP00000366249

Pfam:

PF00240

Uniprot:

O15205

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ELISA Kit for Human Ubiquitin D

Cat.:

E1744h

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96T

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ELISA Kit for Human Ubiquitin D

Cat.:

E1744m

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96T

ELISA Kit for Human Ubiquitin D

Cat.:

E1744r

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Packing:

96T

CLIA Kit for Human Ubiquitin D

Cat.:

U1744m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin D

Cat.:

U1744r

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin D

Cat.:

U1744h

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96T

Polyclonal Antibody for Human Ubiquitin D

Cat.:

P1744Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin D

Cat.:

P1744Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin D

Cat.:

P1744Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Ubiquitin D

Protein for Human Ubiquitin D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells."
Bates E.E.M. , Ravel O. , Dieu M.-C. , Ho S. , Guret C. , Bridon J.-M. , Ait-Yahia S. , Briere F. , Caux C. , Banchereau J. , Lebecque S.
Eur. J. Immunol.27:2471-2477(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-160;TISSUE SPECIFICITY
2.

"A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2."
Liu Y.-C. , Pan J. , Zhang C. , Fan W. , Collinge M. , Bender J.R. , Weissman S.M.
Proc. Natl. Acad. Sci. U.S.A.96:4313-4318(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MAD2L1;VARIANT SER-160
tissue: Spleen.
3.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-160
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-160
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Urinary bladder.
6.

"Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers."
Lee C.G.L. , Ren J. , Cheong I.S.Y. , Ban K.H.K. , Ooi L.L.P.J. , Yong Tan S. , Kan A. , Nuchprayoon I. , Jin R. , Lee K.-H. , Choti M. , Lee L.A.
Oncogene22:2592-2603(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION IN HEPATOCELLULAR CARCINOMA
7.

"NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation."
Hipp M.S. , Raasi S. , Groettrup M. , Schmidtke G.
J. Biol. Chem.279:16503-16510(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUB1L;INDUCTION BY NUB1L
8.

"FAT10, a ubiquitin-independent signal for proteasomal degradation."
Hipp M.S. , Kalveram B. , Raasi S. , Groettrup M. , Schmidtke G.
Mol. Cell. Biol.25:3483-3491(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"FAT10, a gene up-regulated in various cancers, is cell-cycle regulated."
Lim C.-B. , Zhang D. , Lee C.G.
Cell Div.1:20-20(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY CELL CYCLE
10.

"Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease."
Ross M.J. , Wosnitzer M.S. , Ross M.D. , Granelli B. , Gusella G.L. , Husain M. , Kaufman L. , Vasievich M. , D'Agati V.D. , Wilson P.D. , Klotman M.E. , Klotman P.E.
J. Am. Soc. Nephrol.17:996-1004(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION IN HIVAN
11.

"FAT10 plays a role in the regulation of chromosomal stability."
Ren J. , Kan A. , Leong S.H. , Ooi L.L.P.J. , Jeang K.-T. , Chong S.S. , Kon O.L. , Lee C.G.L.
J. Biol. Chem.281:11413-11421(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAD2L1
12.

"The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10."
Schmidtke G. , Kalveram B. , Weber E. , Bochtler P. , Lukasiak S. , Hipp M.S. , Groettrup M.
J. Biol. Chem.281:20045-20054(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUB1L AND PROTEASOME
13.

"p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers."
Zhang D.W. , Jeang K.-T. , Lee C.G.
Oncogene25:2318-2327(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY TP53
14.

"E1-L2 activates both ubiquitin and FAT10."
Chiu Y.-H. , Sun Q. , Chen Z.J.
Mol. Cell27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBA6;THIOESTER FORMATION;INDUCTION BY TNF AND IFNG;MUTAGENESIS OF 164-GLY-GLY-165
15.

"The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."
Kalveram B. , Schmidtke G. , Groettrup M.
J. Cell Sci.121:4079-4088(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HDAC6;SUBCELLULAR LOCATION;ACETYLATION
16.

"Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon."
Lukasiak S. , Schiller C. , Oehlschlaeger P. , Schmidtke G. , Krause P. , Legler D.F. , Autschbach F. , Schirmacher P. , Breuhahn K. , Groettrup M.
Oncogene27:6068-6074(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY CYTOKINES
17.

"Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L."
Schmidtke G. , Kalveram B. , Groettrup M.
FEBS Lett.583:591-594(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system."
Ebstein F. , Lange N. , Urban S. , Seifert U. , Krueger E. , Kloetzel P.-M.
Int. J. Biochem. Cell Biol.41:1205-1215(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
19.

"FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy."
Snyder A. , Alsauskas Z. , Gong P. , Rosenstiel P.E. , Klotman M.E. , Klotman P.E. , Ross M.J.
J. Virol.83:11983-11988(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
20.

"FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging."
Ji F. , Jin X. , Jiao C.-H. , Xu Q.-W. , Wang Z.-W. , Chen Y.-L.
World J. Gastroenterol.15:2228-2233(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
21.

"The ubiquitin-like protein FAT10 mediates NF-kappa-B activation."
Gong P. , Canaan A. , Wang B. , Leventhal J. , Snyder A. , Nair V. , Cohen C.D. , Kretzler M. , D'Agati V. , Weissman S. , Ross M.J.
J. Am. Soc. Nephrol.21:316-326(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION

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