Protein name:
Ubiquitin-conjugating enzyme E2 B ;
Alternative:
Ubiquitin carrier protein B ;RAD6 homolog B (HR6B) ;Ubiquitin-protein ligase B ;Ubiquitin-conjugating enzyme E2(14k) ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Interacts with RAD18, UBR2 and WAC.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Subcellular Location:
Cell membrane
Nucleus
In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Protein Attributes:
50:
MSTPARRRLM | RDFKRLQEDP | PVGVSGAPSE | NNIMQWNAVI | FGPEGTPFED |
100:
GTFKLVIEFS | EEYPNKPPTV | RFLSKMFHPN | VYADGSICLD | ILQNRWSPTY |
150:
DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
Rabbit
ELISA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rabbit Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rabbit Ubiquitin-conjugating enzyme E2 B
Protein for Rabbit Ubiquitin-conjugating enzyme E2 B
Protein for Rabbit Ubiquitin-conjugating enzyme E2 B
Protein for Rabbit Ubiquitin-conjugating enzyme E2 B
Protein for Rabbit Ubiquitin-conjugating enzyme E2 B
Protein for Rabbit Ubiquitin-conjugating enzyme E2 B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]