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Index > Protein center > UBE3A(Gene name) > Human
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  • UBE3A (Gene name),
  • Ubiquitin-protein ligase E3A (Protein name ),  UBE3A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBE3A(E6AP;EPVE6AP;HPVE6A);
    Protein name:
    Ubiquitin-protein ligase E3A;
    Alternative:
    Human papillomavirus E6-associated protein;E6AP ubiquitin-protein ligase;Renal carcinoma antigen NY-REN-54;Oncogenic protein-associated protein E6-AP;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with HCV core protein and targets it to degradation. Interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis. Interacts with BPY2.
    Function:
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    875
    Sequence:
    50:
    MEKLHQCYWK | SGEPQSDDIE | ASRMKRAAAK | HLIERYYHQL | TEGCGNEACT | 
    100:
    NEFCASCPTF | LRMDNNAAAI | KALELYKINA | KLCDPHPSKK | GASSAYLENS | 
    150:
    KGAPNNSCSE | IKMNKKGARI | DFKDVTYLTE | EKVYEILELC | REREDYSPLI | 
    200:
    RVIGRVFSSA | EALVQSFRKV | KQHTKEELKS | LQAKDEDKDE | DEKEKAACSA | 
    250:
    AAMEEDSEAS | SSRIGDSSQG | DNNLQKLGPD | DVSVDIDAIR | RVYTRLLSNE | 
    300:
    KIETAFLNAL | VYLSPNVECD | LTYHNVYSRD | PNYLNLFIIV | MENRNLHSPE | 
    350:
    YLEMALPLFC | KAMSKLPLAA | QGKLIRLWSK | YNADQIRRMM | ETFQQLITYK | 
    400:
    VISNEFNSRN | LVNDDDAIVA | ASKCLKMVYY | ANVVGGEVDT | NHNEEDDEEP | 
    450:
    IPESSELTLQ | ELLGEERRNK | KGPRVDPLET | ELGVKTLDCR | KPLIPFEEFI | 
    500:
    NEPLNEVLEM | DKDYTFFKVE | TENKFSFMTC | PFILNAVTKN | LGLYYDNRIR | 
    550:
    MYSERRITVL | YSLVQGQQLN | PYLRLKVRRD | HIIDDALVRL | EMIAMENPAD | 
    600:
    LKKQLYVEFE | GEQGVDEGGV | SKEFFQLVVE | EIFNPDIGMF | TYDESTKLFW | 
    650:
    FNPSSFETEG | QFTLIGIVLG | LAIYNNCILD | VHFPMVVYRK | LMGKKGTFRD | 
    700:
    LGDSHPVLYQ | SLKDLLEYEG | NVEDDMMITF | QISQTDLFGN | PMMYDLKENG | 
    750:
    DKIPITNENR | KEFVNLYSDY | ILNKSVEKQF | KAFRRGFHMV | TNESPLKYLF | 
    800:
    RPEEIELLIC | GSRNLDFQAL | EETTEYDGGY | TRDSVLIREF | WEIVHSFTDE | 
    850:
    QKRLFLQFTT | GTDRAPVGGL | GKLKMIIAKN | GPDTERLPTS | HTCFNVLLLP | 
    875:
    EYSSKEKLKE | RLLKAITYAK | GFGML
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
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    ELISA Kit for Human Ubiquitin-protein ligase E3A
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    CLIA Kit for Human Ubiquitin-protein ligase E3A
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    CLIA Kit for Human Ubiquitin-protein ligase E3A
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    Polyclonal Antibody for Human Ubiquitin-protein ligase E3A
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    Polyclonal Antibody for Human Ubiquitin-protein ligase E3A
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    P9055Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ubiquitin-protein ligase E3A
    Monoclonal Antibody for Human Ubiquitin-protein ligase E3A
    Protein for Human Ubiquitin-protein ligase E3A
    Protein for Human Ubiquitin-protein ligase E3A

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    Linearity
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    References
    1. 1.
      "The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing."
      Yamamoto Y. , Huibregtse J.M. , Howley P.M.
      Genomics41:263-266(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS I; II AND III);VARIANT GLY-290
      tissue: Keratinocyte.
    2. 2.
      "UBE3A/E6-AP mutations cause Angelman syndrome."
      Kishino T. , Lalande M. , Wagstaff J.
      Nat. Genet.15:70-73(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I)
      tissue: Fetal brain.
    3. 3.
      "De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome."
      Matsuura T. , Sutcliffe J.S. , Fang P. , Galjaard R.-J. , Jiang Y.-H. , Benton C.S. , Rommens J.M. , Beaudet A.L.
      Nat. Genet.15:74-77(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM I);VARIANTS TYR-44 AND THR-201
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM III)
      tissue: Testis.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53."
      Huibregtse J.M. , Scheffner M. , Howley P.M.
      Mol. Cell. Biol.13:775-784(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-875;PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION;VARIANT GLY-290
      tissue: Keratinocyte.
    7. 8.
      "The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate."
      Nuber U. , Schwarz S.E. , Scheffner M.
      Eur. J. Biochem.254:643-649(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 9.
      "Mutations in the E6-AP gene (UBE3A) in patients with Angelman syndrome."
      Hennies H.C. , Buerger J. , Sperling K. , Reis A.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-787;VARIANT GLY-290
    9. 10.
      "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
      Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
      Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN
      tissue: Renal cell carcinoma.
    10. 11.
      "Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination."
      Kumar S. , Talis A.L. , Howley P.M.
      J. Biol. Chem.274:18785-18792(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 12.
      "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome."
      Kleijnen M.F. , Shih A.H. , Zhou P. , Kumar S. , Soccio R.E. , Kedersha N.L. , Gill G. , Howley P.M.
      Mol. Cell6:409-419(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBQLN1 AND UBQLN2
    12. 13.
      "VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A."
      Wong E.Y. , Tse J.Y. , Yao K.M. , Tam P.C. , Yeung W.S.
      Biochem. Biophys. Res. Commun.296:1104-1111(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BPY2
    13. 14.
      "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
      Wang X. , Chen C.-F. , Baker P.R. , Chen P.-L. , Kaiser P. , Huang L.
      Biochemistry46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    14. 15.
      "E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein."
      Shirakura M. , Murakami K. , Ichimura T. , Suzuki R. , Shimoji T. , Fukuda K. , Abe K. , Sato S. , Fukasawa M. , Yamakawa Y. , Nishijima M. , Moriishi K. , Matsuura Y. , Wakita T. , Suzuki T. , Howley P.M. , Miyamura T. , Shoji I.
      J. Virol.81:1174-1185(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV CORE PROTEIN
    15. 16.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 18.
      "The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins."
      Mishra A. , Godavarthi S.K. , Maheshwari M. , Goswami A. , Jana N.R.
      J. Biol. Chem.284:10537-10545(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 19.
      "Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation."
      Shimoji T. , Murakami K. , Sugiyama Y. , Matsuda M. , Inubushi S. , Nasu J. , Shirakura M. , Suzuki T. , Wakita T. , Kishino T. , Hotta H. , Miyamura T. , Shoji I.
      J. Cell. Biochem.106:1123-1135(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    19. 20.
      "UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degrADation of p27."
      Mishra A. , Godavarthi S.K. , Jana N.R.
      Neurobiol. Dis.36:26-34(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 21.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes."
      Martinez-Noel G. , Galligan J.T. , Sowa M.E. , Arndt V. , Overton T.M. , Harper J.W. , Howley P.M.
      Mol. Cell. Biol.32:3095-3106(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIF1AN; MAPK6; NEURL4 AND PSMD4
    23. 24.
      "The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor."
      Gossan N.C. , Zhang F. , Guo B. , Jin D. , Yoshitane H. , Yao A. , Glossop N. , Zhang Y.Q. , Fukada Y. , Meng Q.J.
      Nucleic Acids Res.42:5765-5775(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARNTL
    24. 25.
      "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade."
      Huang L. , Kinnucan E. , Wang G. , Beaudenon S. , Howley P.M. , Huibregtse J.M. , Pavletich N.P.
      Science286:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 495-852 IN COMPLEX WITH UBE2L3
    25. 26.
      "Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP."
      Be X. , Hong Y. , Wei J. , Androphy E.J. , Chen J.J. , Baleja J.D.
      Biochemistry40:1293-1299(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 401-418
    26. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AS ILE-826 INS;VARIANTS HIS-62; THR-201 AND PRO-372
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