UBR1 ELISA Kit for Human(Homo sapiens) | EIAab.comUBR1 ELISA Kit for Human(Homo sapiens)

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UBR1 (Gene name),

E3 ubiquitin-protein ligase UBR1 (Protein name ), UBR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBR1;

Protein name:

E3 ubiquitin-protein ligase UBR1;

Alternative:

Ubiquitin-protein ligase E3-alpha-1;N-recognin-1;Ubiquitin-protein ligase E3-alpha-I;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RECQL4.

Function:

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Subcellular Location:

Cytoplasm cytosol

Protein Attributes:

Sequence length:

1749

Sequence:

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1749:

GLKRGNPLHL | SRERYRKLHL | VWQQHCIIEE | IARSQETNQM | LFGFNWQLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF02617

STRING:

9606.ENSP00000290650

String:

Q8IWV7

UniGene:

Hs.591121

SMR:

Q8IWV7

KEGG:

hsa:197131

MIM:

243800

Uniprot:

Q8IWV7

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ELISA Kit for Human E3 ubiquitin-protein ligase UBR1

Cat.:

E2362h

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Manual:

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96T

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ELISA Kit for Human E3 ubiquitin-protein ligase UBR1

Cat.:

E2362m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase UBR1

Cat.:

U2362m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase UBR1

Cat.:

U2362h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human E3 ubiquitin-protein ligase UBR1

Cat.:

P2362Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human E3 ubiquitin-protein ligase UBR1

Cat.:

P2362Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human E3 ubiquitin-protein ligase UBR1

Protein for Human E3 ubiquitin-protein ligase UBR1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia."
Kwak K.S. , Zhou X. , Solomon V. , Baracos V.E. , Davis J. , Bannon A.W. , Boyle W.J. , Lacey D.L. , Han H.Q.
Cancer Res.64:8193-8198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1."
Dgany O. , Avidan N. , Delaunay J. , Krasnov T. , Shalmon L. , Shalev H. , Eidelitz-Markus T. , Kapelushnik J. , Cattan D. , Pariente A. , Tulliez M. , Cretien A. , Schischmanoff P.-O. , Iolascon A. , Fibach E. , Koren A. , Roessler J. , Le Merrer M. , more...
Am. J. Hum. Genet.71:1467-1474(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1727 (ISOFORM 1)
tissue: Erythroid cell.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-1014 (ISOFORM 1)
tissue: Placenta.
5.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 656-1749 (ISOFORM 2)
tissue: Heart.
6.

"The mouse and human genes encoding the recognition component of the N-end rule pathway."
Kwon Y.T. , Reiss Y. , Fried V.A. , Hershko A. , Yoon J.K. , Gonda D.K. , Sangan P. , Copeland N.G. , Jenkins N.A. , Varshavsky A.
Proc. Natl. Acad. Sci. U.S.A.95:7898-7903(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 702-1034 (ISOFORM 1);TISSUE SPECIFICITY
7.

"RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway."
Yin J. , Kwon Y.T. , Varshavsky A. , Wang W.
Hum. Mol. Genet.13:2421-2430(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RECQL4;IDENTIFICATION BY MASS SPECTROMETRY
8.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1179;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
9.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
11.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
12.

"Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway."
Kume K. , Iizumi Y. , Shimada M. , Ito Y. , Kishi T. , Yamaguchi Y. , Handa H.
Genes Cells15:339-349(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Structural basis of substrate recognition and specificity in the N-end rule pathway."
Matta-Camacho E. , Kozlov G. , Li F.F. , Gehring K.
Nat. Struct. Mol. Biol.17:1182-1187(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 98-167 ALONE AND IN COMPLEX WITH N-END RULE PEPTIDE;UBR-TYPE ZINC-FINGER;FUNCTION;VARIANT JB5 ARG-136
14.

"Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)."
Zenker M. , Mayerle J. , Lerch M.M. , Tagariello A. , Zerres K. , Durie P.R. , Beier M. , Hulskamp G. , Guzman C. , Rehder H. , Beemer F.A. , Hamel B.C.J. , Vanlieferinghen P. , Gershoni-Baruch R. , Vieira M.W. , Dumic M. , Auslender R. , Gil-da-Silva-Lopes V.L. , more...
Nat. Genet.37:1345-1350(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS JBS ARG-136 AND SER-1279;FUNCTION;DISEASE;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE

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