Gene name:
Ubr4(Rbaf600;Zubr1);
Protein name:
E3 ubiquitin-protein ligase UBR4;
Alternative:
Zinc finger UBR1-type protein 1;N-recognin-4;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with RB1 and calmodulin.
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cytoplasm
Cytoplasm
cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
Protein Attributes:
50:
MATSGGEEAA | AAAPAPGAPA | TGQDTTPGWE | VAVRPLLSAS | YSAFEMKELP |
100:
QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV |
150:
AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT |
200:
FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV |
250:
FNPRTVPSPP | ISPQALVEGE | NDEQSSTEQA | SAVKTKNVFI | AQNVASLQEL |
300:
GGSEKLLRVC | LNLPYFLRYI | NRFQDAVVAN | SFFIMPATVA | DATAVRNGFH |
350:
SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL |
400:
HVGSAQQVRT | GSTSSKEEDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG |
450:
EHFQNFQLLG | AWCLLNSLFL | ILHLSPTALA | DKGKEKDPLA | ALRVRDILSR |
500:
TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLTSLFQD | LQVEALHKGW |
550:
ETDGPPAVLS | IMAQSTSTQR | VQRLIDSVPL | TNLLLTLLST | SYRKACVLQR |
600:
QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS |
650:
PSKEKAAPPP | PPPPPPLESS | PRVKSPSKQA | SGEKGNILAS | RKDPELFLGL |
700:
ASNILNFITS | SMLNSRNNFI | RNYLSVSLSE | QHMATLASII | KEVDKDGLKG |
750:
SSDEDFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPL | SSGPWPLYIH |
800:
PQGLSVLSRL | LLIWQHKAGA | QGDPDVPECL | KVWDRFLTTM | KQSALQGVVP |
850:
SETEDLNIEH | LQLLLLIFHS | FSEKGRRAIL | TTLVQSIQEL | SVNMEVQMRS |
900:
APLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSSS |
950:
SSRRANIPLY | HGFKEVEENW | SKHFSSDAAP | QPRFYCVLST | EASEEDLNRL |
1000:
DSEACEVLFS | KLVKYDELYS | SLTALLAAGS | QLDTVKRKEN | KNMTALEACA |
1050:
LQYYFLILWR | ILGILPPSKT | YMNQLAMNSP | EMSECDILHT | LRWSSRLRIS |
1100:
SYVSWIKDHL | IRQGMRPEHA | GSLVELAASK | CSSVKYDVEI | VEEYFARQIS |
1150:
SFCSIDCTTV | LQLHEIPSLQ | SIYTLDAAVS | KVQVSLDEHF | SKMAAETDPH |
1200:
KSSEITKNLL | PATLQLIDTY | ASFTRAYLLQ | NLNEEGSTEK | PSQEKLHGFA |
1250:
AVLAIGSSRC | KANTLGPTLV | QNLPSSVQSV | CESWNNINTN | EFPNIGSWRN |
1300:
AFANDTIPSE | SYISAVQAAH | LGTLCGQSLP | LAASLKHALL | SLVRLTGDLI |
1350:
VWSDEMNPAQ | VIRALLPLLL | ESSTESAAEI | SSNSLERILG | PAESDEFLAR |
1400:
VYEKLITGCY | NILANHADPS | SGLDESVLEE | CLQYLEKQLE | SSQARKAMEE |
1450:
FFSDGGELVQ | IMMATANEDL | SAKFCNRVLK | FFTKLFQLTE | KSPNPSLLHL |
1500:
CGSLAQLACV | EPVRLQAWLT | RMTTSPPKDS | DQLEVIQENR | QLLQLLTTYI |
1550:
VRENSQVGEG | VCAVLLGTLT | PMATDMLANG | DGTGFPELMV | VMATLASAGQ |
1600:
GAGHLQLHNA | AVDWLGRCKK | YLSQKNVVEK | LNANVMHGKH | VMVLECTCHI |
1650:
MSYLADVTNA | LSQSNGQGPS | HLSVDGEERA | IEVDSDWVEE | LAVEEEDSQA |
1700:
EDSDEDSLCN | KLCTFTITQK | EFMNQHWYHC | HTCKMVDGVG | VCTVCAKVCH |
1750:
KDHEISYAKY | GSFFCDCGAK | EDGSCLALVK | RTPSSGMSST | MKESAFQSEP |
1800:
RVSESLVRHA | STSPADKAKV | TISDGKVADE | EKPKKSSLCR | TVEGCREELQ |
1850:
NQANFSFAPL | VLDMLNFLMD | AIQTNFQQAS | AVGSSSRAQQ | ALSELHTVDK |
1900:
VVEMTDQLMV | PTLGSQEGAF | ENVRMNYSGD | QGQTIRQLIS | AHVLRRVAMC |
1950:
VLSSPHGRRQ | HLAVSHEKGK | ITVLQLSALL | KQADSSKRKL | TLTRLASAPV |
2000:
PFTVLSLTGN | PCKEDYLAVC | GLKDCHVLTF | SSSGSVSDHL | VLHPQLATGN |
2050:
FIIKAVWLPG | SQTELAIVTA | DFVKIYDLSV | DALSPTFYFL | LPSSKIRDVT |
2100:
FLFNEEGKNI | IVIMSSAGYM | YTQLMEEASS | AQQGPFYVTN | VLEINHEDLK |
2150:
DSNSQVAGGG | VSVYYSHVLQ | MLFFSYSQGK | SFAATVSRST | LEVLQLFPIN |
2200:
IKSSNGGSKT | SPALCQWSEV | MNHPGLVCCV | QQTTGVPLVV | MVKPDTFLIQ |
2250:
EIKTLPAKAK | IQDMVAIRHT | ACNEQQRTTM | ILLCEDGSLR | IYMANVENTS |
2300:
YWLQPSLQPS | SVISIMKPVR | KRKTATITAR | TSSQVTFPID | FFEHNQQLTD |
2350:
VEFGGNDLLQ | VYNAQQIKHR | LNSTGMYVAN | TKPGGFTMEI | SNNSSTMVMT |
2400:
GMRIQIGTQA | IERAPSYIEI | FGRTMQLNLS | RSRWFDFPFT | REEALQADRK |
2450:
LNLFIGASVD | PAGVTMIDAV | KIYGKTKEQF | GWPDEPPEDF | PSASVSSVCP |
2500:
PNLNQSNSTG | DSDSAAPATT | SGTVLERLVV | SSLEALESCF | AVGPIIEKER |
2550:
NKHAAQELAT | LLLSLPAPAS | VQQQSKSLLA | SLHSSRSAYH | SHKDQALLSK |
2600:
AVQCLNTSSK | EGKDLDPEVF | QRLVITARSI | AVTRPNNLVH | FTESKLPQME |
2650:
TEGAEEGKEP | QKQVEGDGCS | FITQLVNHFW | KLHASKPKNA | FLAPACLPGL |
2700:
THIEATVNAL | VDIIHGYCTC | ELDCINTASK | IYMQMLLCPD | PAVSFSCKQA |
2750:
LIRVLRPRNK | RRHVTLPSSP | RSNTPMGDKD | DDDDDDADEK | MQSSGIPDGG |
2800:
HIRQESQEQS | EVDHGDFEMV | SESMVLETAE | NVNNGNPSPL | EALLAGAEGF |
2850:
PPMLDIPPDA | DDETMVELAI | ALSLQQDQQG | SSSSALGLQS | LGLSGQAPSS |
2900:
SSLDAGTLSD | TTASGVCACN | SSVTLSAPAS | DDEGSTAATD | GSTLRTSPAD |
2950:
HGGSVGSESG | GSAVDSVAGE | HSVSGRSSAY | GDATAEGHPA | GPGSVSSSTG |
3000:
AISTTTGHQE | GDGSEGEGEG | EAEGDVHTSN | RLHMVRLMLL | ERLLQTLPQL |
3050:
RNVGGVRAIP | YMQVILMLTT | DLDGEDEKDK | GALDNLLAQL | IAELGMDKKD |
3100:
VSKKNERSAL | NEVHLVVMRL | LSVFMSRTKS | GSKSSICESS | SLISSATAAA |
3150:
LLSSGAVDYC | LHVLKSLLEY | WKGQQSEEEP | VTTSQLLKPH | TTSSPPDMSP |
3200:
FFLRQYVKGH | AADVFEAYTQ | LLTEMVLRLP | YQIKKIADTS | SRIPPPVFDH |
3250:
SWFYFLSEYL | MIQQTPFVRR | QVRKLLLFIC | GSKEKYRQLR | DLHTLDSHVR |
3300:
GIKKLLEEQG | IFLRASVVTA | SSGSALQYDT | LISLMEHLKA | CAEIAAQRTI |
3350:
NWQKFCIKDD | SVLYFLLQVS | FLVDEGVSPV | LLQLLSCALC | GSKVLAALAA |
3400:
STGSSSVASS | APPAASSGQT | TTQSKSSTKK | SKKEKKEKEK | EGESSGSQED |
3450:
QLCTALVNQL | NRFADKETLI | QFLRCFLLES | NSSSVRWQAH | CLTLHIYRNS |
3500:
NKAQQELLLD | LMWSIWPELP | AYGRKAAQFV | DLLGYFSLKT | AQTEKKLKEY |
3550:
SQKAVEILRT | QNHILTNHPN | SNIYNTLSGL | VEFDGYYLES | DPCLVCNNPE |
3600:
VPFCYIKLSS | IKVDTRYTTT | QQVVKLIGSH | TISKVTVKIG | DLKRTKMVRT |
3650:
INLYYNNRTV | QAIVELKNKP | ARWHKAKKVQ | LTPGQTEVKI | DLPLPIVASN |
3700:
LMIEFADFYE | NYQASTETLQ | CPRCSASVPA | NPGVCGNCGE | NVYQCHKCRS |
3750:
INYDEKDPFL | CNACGFCKYA | RFDFMLYAKP | CCAVDPIENE | EDRKKAVSNI |
3800:
NTLLDKADRV | YHQLMGHRPQ | LENLLCKVNE | AAPEKPQEDS | GTAGGISSTS |
3850:
ASVNRYILQL | AQEYCGDCKN | SFDELSKIIQ | KVFASRKELL | EYDLQQREAA |
3900:
TKSSRTSVQP | TFTASQYRAL | SVLGCGHTSS | TKCYGCASAV | TEHCITLLRA |
3950:
LATNPALRHI | LVSQGLIREL | FDYNLRRGAA | AIREEVRQLM | CLLTRDNPEA |
4000:
TQQMNDLIIG | KVSTALKGHW | ANPDLASSLQ | YEMLLLTDSI | SKEDSCWELR |
4050:
LRCALSLFLM | AVNIKTPVVV | ENITLMCLRI | LQKLIKPPAP | TSKKNKDVPV |
4100:
EALTTVKPYC | NEIHAQAQLW | LKRDPKASYE | AWKKCLPIRG | VDGNGKSPSK |
4150:
SELHRLYLTE | KYVWRWKQFL | SRRGKRTTPL | DLKLGHNNWL | RQVLFTPATQ |
4200:
AARQAACTIV | EALASVPSRK | QQVLDLLTSY | LDELSVAGEC | AAEYLALYQK |
4250:
LIASCHWKVY | LAARGVLPYV | GNLITKEIAR | LLALEEATLS | TDLQQGYALK |
4300:
SLTGLLSSFV | EVESIKRHFK | SRLVGTVLNG | YLCLRKLVLQ | RTKLIDETQD |
4350:
MLLEMLEDMT | TGTESETKAF | MAVCIETAKR | YNLDDYRTPV | FIFERLCSII |
4400:
YPEENEVTEF | FVTLEKDPQQ | EDFLQGRMPG | NPYSSNEPGI | GPLMRDIKNK |
4450:
ICQDCDLVAL | LEDDSGMELL | VNNKIISLDL | PVAEVYKKVW | CTTNEGEPMR |
4500:
IVYRMRGLLG | DATEEFIESL | DSTTDEEEDE | EEVYRMAGVM | AQCGGLQCML |
4550:
NRLAGVKDFK | QGRHLLTVLL | KLFSYCVKVK | VNRQQLVKLE | MNTLNVMLGT |
4600:
LNLALVAEQE | SKDSGGAAVA | EQVLSIMEII | LDESNAEPLS | EDKGNLLLTG |
4650:
DKDQLVMLLD | QINSTFVRSN | PSVLQGLLRI | IPYLSFGEVE | KMQILVERFK |
4700:
PYCSFDKYDE | DHSGDDKVFL | DCFCKIAAGI | KNNSNGHQLK | DLILQKGITQ |
4750:
SALDYMKKHI | PSAKNLDADI | WKKFLSRPAL | PFILRLLRGL | AMQHPATQVL |
4800:
IGTDSITSLH | KLEQVSSDEG | IGTLAENLLE | ALREHPDVNK | KIDAARRETR |
4850:
AEKKRMAMAM | RQKALGTLGM | TTNEKGQVVT | KTALLKQMEE | LIEEPGLTCC |
4900:
ICREGYKFQP | TKVLGIYTFT | KRVALEEMEN | KPRKQQGYST | VSHFNIVHYD |
4950:
CHLAAVRLAR | GREEWESAAL | QNANTKCNGL | LPVWGPHVPE | SAFATCLARH |
5000:
NTYLQECTGQ | REPTYQLNIH | DIKLLFLRFA | MEQSFSADTG | GGGRESNIHL |
5050:
IPYIIHTVLY | VLNTTRATSR | EEKNLQGFLE | QPREKWTESA | FDVDGPHYFT |
5100:
ILALHVLPPE | QWKATRVEIL | RRLLVASHAR | AVAPGGATRL | TDKAVKDYSA |
5150:
YRSSLLFWAL | VDLIYNMFKK | VPTSNTEGGW | SCSLAEYIRH | NDMPIYEAAD |
5194:
KALKTFQEEF | MPVETFSEFL | DAAGLLSEIT | DPESFLKDLL | NSVP
Vaild Sequence:
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Uniprot: