UCHL1 ELISA Kit for Human(Homo sapiens) | EIAab.comUCHL1 ELISA Kit for Human(Homo sapiens)

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UCHL1 (Gene name),

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Protein name ), UCHL1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UCHL1;

Protein name:

Ubiquitin carboxyl-terminal hydrolase isozyme L1(UCH-L1);

Alternative:

PGP 9.5(PGP9.5);Neuron cytoplasmic protein 9.5;Ubiquitin thioesterase L1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.

Function:

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

223

Sequence:

50:

100:

150:

200:

223:

CREFTEREQG | EVRFSAVALC | KAA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P09936

KEGG:

hsa:7345

UniGene:

Hs.518731

STRING:

9606.ENSP00000284440

SMR:

P09936

MIM:

191342

Pfam:

PF01088

Uniprot:

P09936

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ELISA Kit for Human UCH-L1

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E1741h

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96T

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ELISA Kit for Human UCH-L1

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E1741p

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96T

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ELISA Kit for Human UCH-L1

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E1741r

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96T

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ELISA Kit for Human UCH-L1

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E1741m

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96T

ELISA Kit for Human UCH-L1

Cat.:

E1741b

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96T

CLIA Kit for Human UCH-L1

Cat.:

U1741r

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96T

CLIA Kit for Human UCH-L1

Cat.:

U1741p

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96T

CLIA Kit for Human UCH-L1

Cat.:

U1741b

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96T

CLIA Kit for Human UCH-L1

Cat.:

U1741m

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Packing:

96T

CLIA Kit for Human UCH-L1

Cat.:

U1741h

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96T

Polyclonal Antibody for Human UCH-L1

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P1741Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human UCH-L1

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P1741Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human UCH-L1

Cat.:

P1741Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human UCH-L1

Protein for Human UCH-L1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
tissue: Muscle.
4.

"The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase."
Day I.N.M. , Hinks L.J. , Thompson R.J.
Biochem. J.268:521-524(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-15
5.

"Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases."
Choi J. , Levey A.I. , Weintraub S.T. , Rees H.D. , Gearing M. , Chin L.-S. , Li L.
J. Biol. Chem.279:13256-13264(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-15 AND 214-221;SUSCEPTIBILITY TO OXIDATION;IDENTIFICATION BY MASS SPECTROMETRY;TISSUE SPECIFICITY
6.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-15; 20-27; 66-78; 84-129; 136-195 AND 214-221;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
7.

"Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells."
Day I.N.M. , Thompson R.J.
FEBS Lett.210:157-160(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-223;PARTIAL PROTEIN SEQUENCE
8.

"The ubiquitin pathway in Parkinson's disease."
Leroy E. , Boyer R. , Auburger G. , Leube B. , Ulm G. , Mezey E. , Harta G. , Brownstein M.J. , Jonnalagada S. , Chernova T. , Dehejia A. , Lavedan C. , Gasser T. , Steinbach P.J. , Wilkinson K.D. , Polymeropoulos M.H.
Nature395:451-452(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-223;VARIANT PARK5 MET-93;CHARACTERIZATION OF VARIANT PARK5 MET-93;BIOPHYSICOCHEMICAL PROPERTIES
9.

"Neuronal protein gene product 9.5 (IEF SSP 6104) is expressed in cultured human MRC-5 fibroblasts of normal origin and is strongly down-regulated in their SV40 transformed counterparts."
Honore B. , Rasmussen H.H. , Vandekerckhove J. , Celis J.E.
FEBS Lett.280:235-240(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-25; 79-81; 106-121 AND 134-151
10.

"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-25; 79-91; 106-123 AND 136-151
11.

"Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues."
Larsen C.N. , Price J.S. , Wilkinson K.D.
Biochemistry35:6735-6744(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;MUTAGENESIS OF GLN-73; CYS-90; HIS-97; HIS-161 AND ASP-176;BIOPHYSICOCHEMICAL PROPERTIES
12.

"Cleavage of the C-terminus of NEDD8 by UCH-L3."
Wada H. , Kito K. , Caskey L.S. , Yeh E.T.H. , Kamitani T.
Biochem. Biophys. Res. Commun.251:688-692(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
13.

"The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility."
Liu Y. , Fallon L. , Lashuel H.A. , Liu Z. , Lansbury P.T. Jr.
Cell111:209-218(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANT PARK5 MET-93;CHARACTERIZATION OF VARIANT TYR-18
14.

"Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)."
Caballero O.L. , Resto V. , Patturajan M. , Meerzaman D. , Guo M.Z. , Engles J. , Yochem R. , Ratovitski E. , Sidransky D. , Jen J.
Oncogene21:3003-3010(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
15.

"Mechanistic studies of ubiquitin C-terminal hydrolase L1."
Case A. , Stein R.L.
Biochemistry45:2443-2452(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE
16.

"Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease."
Liu Z. , Meray R.K. , Grammatopoulos T.N. , Fredenburg R.A. , Cookson M.R. , Liu Y. , Logan T. , Lansbury P.T. Jr.
Proc. Natl. Acad. Sci. U.S.A.106:4635-4640(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ISOPRENYLATION AT CYS-220
17.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1."
Das C. , Hoang Q.Q. , Kreinbring C.A. , Luchansky S.J. , Meray R.K. , Ray S.S. , Lansbury P.T. , Ringe D. , Petsko G.A.
Proc. Natl. Acad. Sci. U.S.A.103:4675-4680(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS);SUBUNIT
20.

"Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation."
Boudreaux D.A. , Maiti T.K. , Davies C.W. , Das C.
Proc. Natl. Acad. Sci. U.S.A.107:9117-9122(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF VARIANTS TYR-18 AND MET-93 IN COMPLEX WITH UBIQUITIN;CATALYTIC ACTIVITY;ACTIVE SITE;MUTAGENESIS OF CYS-90 AND PHE-204
21.

"Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants."
Nishikawa K. , Li H. , Kawamura R. , Osaka H. , Wang Y.-L. , Hara Y. , Hirokawa T. , Manago Y. , Amano T. , Noda M. , Aoki S. , Wada K.
Biochem. Biophys. Res. Commun.304:176-183(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT PARK5 MET-93;CHARACTERIZATION OF VARIANT TYR-18;MUTAGENESIS OF CYS-90;BIOPHYSICOCHEMICAL PROPERTIES
22.

"The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease."
Harhangi B.S. , Farrer M.J. , Lincoln S. , Bonifati V. , Meco G. , De Michele G. , Brice A. , Durr A. , Martinez M. , Gasser T. , Bereznai B. , Vaughan J.R. , Wood N.W. , Hardy J. , Oostra B.A. , Breteler M.M.
Neurosci. Lett.270:1-4(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-93
23.

"Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease."
Lincoln S. , Vaughan J. , Wood N. , Baker M. , Adamson J. , Gwinn-Hardy K. , Lynch T. , Hardy J. , Farrer M.
NeuroReport10:427-429(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-18
24.

"The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease."
Mellick G.D. , Silburn P.A.
Neurosci. Lett.293:127-130(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-18
25.

"UCHL1 is a Parkinson's disease susceptibility gene."
UCHL1 global genetics consortium , Maraganore D.M. , Lesnick T.G. , Elbaz A. , Chartier-Harlin M.-C. , Gasser T. , Krueger R. , Hattori N. , Mellick G.D. , Quattrone A. , Satoh J. , Toda T. , Wang J. , Ioannidis J.P.A. , de Andrade M. , Rocca W.A.
Ann. Neurol.55:512-521(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-18
26.

UCHL1 global genetics consortium , Maraganore D.M. , Lesnick T.G. , Elbaz A. , Chartier-Harlin M.-C. , Gasser T. , Krueger R. , Hattori N. , Mellick G.D. , Quattrone A. , Satoh J. , Toda T. , Wang J. , Ioannidis J.P.A. , de Andrade M. , Rocca W.A.
Ann. Neurol.55:899-899(2004)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
27.

"UCHL-1 is not a Parkinson's disease susceptibility gene."
Healy D.G. , Abou-Sleiman P.M. , Casas J.P. , Ahmadi K.R. , Lynch T. , Gandhi S. , Muqit M.M. , Foltynie T. , Barker R. , Bhatia K.P. , Quinn N.P. , Lees A.J. , Gibson J.M. , Holton J.L. , Revesz T. , Goldstein D.B. , Wood N.W.
Ann. Neurol.59:627-633(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-18;LACK OF ASSOCIATION OF VARIANT TYR-18 WITH PARKINSON DISEASE
28.

"The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells."
Kyratzi E. , Pavlaki M. , Stefanis L.
Hum. Mol. Genet.17:2160-2171(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT TYR-18;ANTIOXIDANT FUNCTION IN NEURONAL CELLS
29.

"Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts."
Rudolph T. , Sjolander A. , Palmer M.S. , Minthon L. , Wallin A. , Andreasen N. , Tasa G. , Juronen E. , Blennow K. , Zetterberg H. , Zetterberg M.
Ophthalmic Genet.32:75-79(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-18
30.

"Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration."
Bilguvar K. , Tyagi N.K. , Ozkara C. , Tuysuz B. , Bakircioglu M. , Choi M. , Delil S. , Caglayan A.O. , Baranoski J.F. , Erturk O. , Yalcinkaya C. , Karacorlu M. , Dincer A. , Johnson M.H. , Mane S. , Chandra S.S. , Louvi A. , Boggon T.J. , more...
Proc. Natl. Acad. Sci. U.S.A.110:3489-3494(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NDGOA ALA-7;CHARACTERIZATION OF VARIANT NDGOA ALA-7

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