Gene name:
UCP2 (SLC25A8) ;
Protein name:
Mitochondrial uncoupling protein 2 (UCP 2) ;
Alternative:
UCPH ;Solute carrier family 25 member 8 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Acts as a dimer forming a proton channel.
Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Subcellular Location:
Mitochondrion inner membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVGFKATDVP | PTATVKFLGA | GTAACIADLI | TFPLDTAKVR | LQIQGESQGP |
100:
VRATASAQYR | GVMGTILTMV | RTEGPRSLYN | GLVAGLQRQM | SFASVRIGLY |
150:
DSVKQFYTKG | SEHASIGSRL | LAGSTTGALA | VAVAQPTDVV | KVRFQAQARA |
200:
GGGRRYQSTV | NAYKTIAREE | GFRGLWKGTS | PNVARNAIVN | CAELVTYDLI |
250:
KDALLKANLM | TDDLPCHFTS | AFGAGFCTTV | IASPVDVVKT | RYMNSALGQY |
300:
SSAGHCALTM | LQKEGPRAFY | KGFMPSFLRL | GSWNVVMFVT | YEQLKRALMA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Pig
Dog
Mouse
ELISA Kit for Human UCP 2
ELISA Kit for Human UCP 2
ELISA Kit for Human UCP 2
ELISA Kit for Human UCP 2
ELISA Kit for Human UCP 2
ELISA Kit for Human UCP 2
Polyclonal Antibody for Human UCP 2
Polyclonal Antibody for Human UCP 2
Polyclonal Antibody for Human UCP 2
Polyclonal Antibody for Human UCP 2
Polyclonal Antibody for Human UCP 2
Polyclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
Monoclonal Antibody for Human UCP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Y Aslan, Ş Kader, M Mutlu, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .
2.
"Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia."
Fleury C.
,
Neverova M.
,
Collins S.
,
Raimbault S.
,
Champigny O.
,
Levi-Meyrueis C.
,
Bouillaud F.
,
Seldin M.F.
,
Surwit R.S.
,
Ricquier D.
,
Warden C.H.
Nat. Genet.15:269-272(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Lung .
tissue :
Skeletal muscle .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-55
tissue :
Spleen .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-55
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-55
tissue :
Adipose tissue .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-55; GLN-76; GLN-154; GLY-268 AND CYS-282
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
B-cell .
10.
"A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans."
Esterbauer H.
,
Schneitler C.
,
Oberkofler H.
,
Ebenbichler C.
,
Paulweber B.
,
Sandhofer F.
,
Ladurner G.
,
Hell E.
,
Strosberg A.D.
,
Patsch J.R.
,
Krempler F.
,
Patsch W.
Nat. Genet.28:178-183(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN BMIQ4 AND SUSCEPTIBILITY TO OBESITY