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Index > Protein center > UCP2(Gene name) > Human
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  • UCP2 (Gene name),
  • Mitochondrial uncoupling protein 2 (Protein name ),  UCP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    UCP2(SLC25A8);
    Protein name:
    Mitochondrial uncoupling protein 2(UCP 2);
    Alternative:
    UCPH;Solute carrier family 25 member 8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Acts as a dimer forming a proton channel.
    Function:
    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
    Subcellular Location:
    Mitochondrion inner membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    309
    Sequence:
    50:
    MVGFKATDVP | PTATVKFLGA | GTAACIADLI | TFPLDTAKVR | LQIQGESQGP | 
    100:
    VRATASAQYR | GVMGTILTMV | RTEGPRSLYN | GLVAGLQRQM | SFASVRIGLY | 
    150:
    DSVKQFYTKG | SEHASIGSRL | LAGSTTGALA | VAVAQPTDVV | KVRFQAQARA | 
    200:
    GGGRRYQSTV | NAYKTIAREE | GFRGLWKGTS | PNVARNAIVN | CAELVTYDLI | 
    250:
    KDALLKANLM | TDDLPCHFTS | AFGAGFCTTV | IASPVDVVKT | RYMNSALGQY | 
    300:
    SSAGHCALTM | LQKEGPRAFY | KGFMPSFLRL | GSWNVVMFVT | YEQLKRALMA | 
    309:
    ACTSREAPF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human UCP 2
    Cat.:
    E2066h
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    96T
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    ELISA Kit for Human UCP 2
    Cat.:
    E2066b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human UCP 2
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    E2066r
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    Packing:
    96T
    ELISA Kit for Human UCP 2
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    E2066p
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    96T
    ELISA Kit for Human UCP 2
    Cat.:
    E2066d
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    96T
    ELISA Kit for Human UCP 2
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    E2066m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 2
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    U2066p
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    96T
    CLIA Kit for Human UCP 2
    Cat.:
    U2066d
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    96T
    CLIA Kit for Human UCP 2
    Cat.:
    U2066m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UCP 2
    Cat.:
    U2066r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UCP 2
    Cat.:
    U2066h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human UCP 2
    Cat.:
    U2066b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human UCP 2
    Polyclonal Antibody for Human UCP 2
    Polyclonal Antibody for Human UCP 2
    Cat.:
    P2066Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 2
    Polyclonal Antibody for Human UCP 2
    Cat.:
    P2066Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 2
    Cat.:
    P2066Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human UCP 2
    Monoclonal Antibody for Human UCP 2
    Monoclonal Antibody for Human UCP 2
    Monoclonal Antibody for Human UCP 2
    Monoclonal Antibody for Human UCP 2
    Monoclonal Antibody for Human UCP 2
    Protein for Human UCP 2
    Protein for Human UCP 2
    Protein for Human UCP 2
    Protein for Human UCP 2
    Protein for Human UCP 2
    Protein for Human UCP 2

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    Linearity
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    References
    1. 1.
      "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression."
      Boss O. , Samec S. , Paoloni-Giacobino A. , Dulloo A. , Seydoux J. , Rossier C. , Muzzin P. , Giacobino J.-P.
      FEBS Lett.408:39-42(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
      tissue: Skeletal muscle.
    3. 3.
      "Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis."
      Gimeno R.E. , Dembski M. , Weng X. , Deng N. , Shyjan A.W. , Gimeno C.J. , Iris F. , Ellis S.J. , Woolf E.A. , Tartaglia L.A.
      Diabetes46:900-906(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-55
      tissue: Spleen.
    4. 4.
      Klannemark M. , Orho M. , Groop L.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-55
    5. 5.
      "Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects."
      Argyropoulos G. , Brown A.M. , Peterson R. , Likes C.E. , Watson D.K. , Garvey W.T.
      Diabetes47:685-687(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene."
      Pecqueur C. , Cassard-Doulcier A.M. , Raimbault S. , Miroux B. , Fleury C. , Gelly C. , Bouillaud F. , Ricquier D.
      Biochem. Biophys. Res. Commun.255:40-46(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    7. 7.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-55
      tissue: Adipose tissue.
    8. 8.
      NIEHS SNPs program
      Submitted (2005-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-55; GLN-76; GLN-154; GLY-268 AND CYS-282
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: B-cell.
    10. 10.
      "A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans."
      Esterbauer H. , Schneitler C. , Oberkofler H. , Ebenbichler C. , Paulweber B. , Sandhofer F. , Ladurner G. , Hell E. , Strosberg A.D. , Patsch J.R. , Krempler F. , Patsch W.
      Nat. Genet.28:178-183(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BMIQ4 AND SUSCEPTIBILITY TO OBESITY
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