UGT1A6 ELISA Kit for Human(Homo sapiens) | EIAab.comUGT1A6 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UGT1A6(Gene name) > Human

UGT1A6 (Gene name),

UDP-glucuronosyltransferase 1-6 (Protein name ), UD16_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UGT1A6(GNT1;UGT1);

Protein name:

UDP-glucuronosyltransferase 1-6(UDPGT 1-6;UGT1*6;UGT1-06;UGT1.6);

Alternative:

UDP-glucuronosyltransferase 1-F(UGT-1F;UGT1F);Phenol-metabolizing UDP-glucuronosyltransferase;UDP-glucuronosyltransferase 1A6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Subcellular Location:

Microsome Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

532

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

532:

VAFITFKCCA | YGYRKCLGKK | GRVKKAHKSK | TH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.554822

SMR:

P19224

MIM:

191740

String:

P19224

Pfam:

PF00201

KEGG:

hsa:54578

STRING:

9606.ENSP00000303174

Uniprot:

P19224

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ELISA Kit for Human UDPGT 1-6

Cat.:

E12958h

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human UDPGT 1-6

Cat.:

E12958m

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MSDS:

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Packing:

96T

CLIA Kit for Human UDPGT 1-6

Cat.:

U12958h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human UDPGT 1-6

Cat.:

U12958m

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Packing:

96T

Polyclonal Antibody for Human UDPGT 1-6

Cat.:

P12958Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human UDPGT 1-6

Monoclonal Antibody for Human UDPGT 1-6

Protein for Human UDPGT 1-6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
Ritter J.K. , Chen F. , Sheen Y.Y. , Tran H.M. , Kimura S. , Yeatman M.T. , Owens I.S.
J. Biol. Chem.267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;VARIANTS TYR-70 AND PRO-510
2.

"Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells."
Harding D. , Fournel-Gigleux S. , Jackson M.R. , Burchell B.
Proc. Natl. Acad. Sci. U.S.A.85:8381-8385(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
3.

"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
Gong Q.H. , Cho J.W. , Huang T. , Potter C. , Gholami N. , Basu N.K. , Kubota S. , Carvalho S. , Pennington M.W. , Owens I.S. , Popescu N.C.
Pharmacogenetics11:357-368(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Guillemette C. , Levesque E. , Girard H. , Bernard O.
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANTS ALA-181 AND SER-184
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-488 (ISOFORM 2)
7.

"Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6."
Muenzel P.A. , Lehmkoester T. , Brueck M. , Ritter J.K. , Bock K.W.
Arch. Biochem. Biophys.350:72-78(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
8.

"Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
Girard H. , Levesque E. , Bellemare J. , Journault K. , Caillier B. , Guillemette C.
Pharmacogenet. Genomics17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
9.

"Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."
Bellemare J. , Rouleau M. , Girard H. , Harvey M. , Guillemette C.
Drug Metab. Dispos.38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
10.

"Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications."
Ciotti M. , Marrone A. , Potter C. , Owens I.S.
Pharmacogenetics7:485-495(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-181 AND SER-184
11.

"Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells."
Nagar S. , Zalatoris J.J. , Blanchard R.L.
Pharmacogenetics14:487-499(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-7; ALA-181 AND SER-184
12.

"Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."
Menard V. , Girard H. , Harvey M. , Perusse L. , Guillemette C.
Hum. Mutat.30:677-687(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-181 AND SER-184

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