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Index > Protein center > UGT1A6(Gene name) > Human
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  • UGT1A6 (Gene name),
  • UDP-glucuronosyltransferase 1-6 (Protein name ),  UD16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UGT1A6(GNT1;UGT1);
    Protein name:
    UDP-glucuronosyltransferase 1-6(UDPGT 1-6;UGT1*6;UGT1-06;UGT1.6);
    Alternative:
    UDP-glucuronosyltransferase 1A6;Phenol-metabolizing UDP-glucuronosyltransferase;UDP-glucuronosyltransferase 1-F(UGT-1F;UGT1F);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
    Subcellular Location:
    Microsome Endoplasmic reticulum membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    532
    Sequence:
    50:
    MACLLRSFQR | ISAGVFFLAL | WGMVVGDKLL | VVPQDGSHWL | SMKDIVEVLS | 
    100:
    DRGHEIVVVV | PEVNLLLKES | KYYTRKIYPV | PYDQEELKNR | YQSFGNNHFA | 
    150:
    ERSFLTAPQT | EYRNNMIVIG | LYFINCQSLL | QDRDTLNFFK | ESKFDALFTD | 
    200:
    PALPCGVILA | EYLGLPSVYL | FRGFPCSLEH | TFSRSPDPVS | YIPRCYTKFS | 
    250:
    DHMTFSQRVA | NFLVNLLEPY | LFYCLFSKYE | ELASAVLKRD | VDIITLYQKV | 
    300:
    SVWLLRYDFV | LEYPRPVMPN | MVFIGGINCK | KRKDLSQEFE | AYINASGEHG | 
    350:
    IVVFSLGSMV | SEIPEKKAMA | IADALGKIPQ | TVLWRYTGTR | PSNLANNTIL | 
    400:
    VKWLPQNDLL | GHPMTRAFIT | HAGSHGVYES | ICNGVPMVMM | PLFGDQMDNA | 
    450:
    KRMETKGAGV | TLNVLEMTSE | DLENALKAVI | NDKSYKENIM | RLSSLHKDRP | 
    500:
    VEPLDLAVFW | VEFVMRHKGA | PHLRPAAHDL | TWYQYHSLDV | IGFLLAVVLT | 
    532:
    VAFITFKCCA | YGYRKCLGKK | GRVKKAHKSK | TH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human UDPGT 1-6
    Cat.:
    E12958h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human UDPGT 1-6
    Cat.:
    E12958m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UDPGT 1-6
    Cat.:
    U12958h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human UDPGT 1-6
    Cat.:
    U12958m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human UDPGT 1-6
    Polyclonal Antibody for Human UDPGT 1-6
    Cat.:
    P12958Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human UDPGT 1-6
    Monoclonal Antibody for Human UDPGT 1-6
    Protein for Human UDPGT 1-6
    Protein for Human UDPGT 1-6

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
      Ritter J.K. , Chen F. , Sheen Y.Y. , Tran H.M. , Kimura S. , Yeatman M.T. , Owens I.S.
      J. Biol. Chem.267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;VARIANTS TYR-70 AND PRO-510
    2. 2.
      "Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells."
      Harding D. , Fournel-Gigleux S. , Jackson M.R. , Burchell B.
      Proc. Natl. Acad. Sci. U.S.A.85:8381-8385(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    3. 3.
      "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
      Gong Q.H. , Cho J.W. , Huang T. , Potter C. , Gholami N. , Basu N.K. , Kubota S. , Carvalho S. , Pennington M.W. , Owens I.S. , Popescu N.C.
      Pharmacogenetics11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      Guillemette C. , Levesque E. , Girard H. , Bernard O.
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANTS ALA-181 AND SER-184
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-488 (ISOFORM 2)
    7. 7.
      "Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6."
      Muenzel P.A. , Lehmkoester T. , Brueck M. , Ritter J.K. , Bock K.W.
      Arch. Biochem. Biophys.350:72-78(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
    8. 8.
      "Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
      Girard H. , Levesque E. , Bellemare J. , Journault K. , Caillier B. , Guillemette C.
      Pharmacogenet. Genomics17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    9. 9.
      "Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."
      Bellemare J. , Rouleau M. , Girard H. , Harvey M. , Guillemette C.
      Drug Metab. Dispos.38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    10. 10.
      "Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications."
      Ciotti M. , Marrone A. , Potter C. , Owens I.S.
      Pharmacogenetics7:485-495(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-181 AND SER-184
    11. 11.
      "Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells."
      Nagar S. , Zalatoris J.J. , Blanchard R.L.
      Pharmacogenetics14:487-499(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-7; ALA-181 AND SER-184
    12. 12.
      "Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."
      Menard V. , Girard H. , Harvey M. , Perusse L. , Guillemette C.
      Hum. Mutat.30:677-687(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-181 AND SER-184
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