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Index > Protein center > UNC5C(Gene name) > Human
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  • UNC5C (Gene name),
  • Netrin receptor UNC5C (Protein name ),  UNC5C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UNC5C(UNC5H3);
    Protein name:
    Netrin receptor UNC5C;
    Alternative:
    Protein unc-5 homolog C;Protein unc-5 homolog 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the cytoplasmic part of DCC.
    Function:
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    931
    Sequence:
    50:
    MRKGLRATAA | RCGLGLGYLL | QMLVLPALAL | LSASGTGSAA | QDDDFFHELP | 
    100:
    ETFPSDPPEP | LPHFLIEPEE | AYIVKNKPVN | LYCKASPATQ | IYFKCNSEWV | 
    150:
    HQKDHIVDER | VDETSGLIVR | EVSIEISRQQ | VEELFGPEDY | WCQCVAWSSA | 
    200:
    GTTKSRKAYV | RIAYLRKTFE | QEPLGKEVSL | EQEVLLQCRP | PEGIPVAEVE | 
    250:
    WLKNEDIIDP | VEDRNFYITI | DHNLIIKQAR | LSDTANYTCV | AKNIVAKRKS | 
    300:
    TTATVIVYVN | GGWSTWTEWS | VCNSRCGRGY | QKRTRTCTNP | APLNGGAFCE | 
    350:
    GQSVQKIACT | TLCPVDGRWT | PWSKWSTCGT | ECTHWRRREC | TAPAPKNGGK | 
    400:
    DCDGLVLQSK | NCTDGLCMQT | APDSDDVALY | VGIVIAVIVC | LAISVVVALF | 
    450:
    VYRKNHRDFE | SDIIDSSALN | GGFQPVNIKA | ARQDLLAVPP | DLTSAAAMYR | 
    500:
    GPVYALHDVS | DKIPMTNSPI | LDPLPNLKIK | VYNTSGAVTP | QDDLSEFTSK | 
    550:
    LSPQMTQSLL | ENEALSLKNQ | SLARQTDPSC | TAFGSFNSLG | GHLIVPNSGV | 
    600:
    SLLIPAGAIP | QGRVYEMYVT | VHRKETMRPP | MDDSQTLLTP | VVSCGPPGAL | 
    650:
    LTRPVVLTMH | HCADPNTEDW | KILLKNQAAQ | GQWEDVVVVG | EENFTTPCYI | 
    700:
    QLDAEACHIL | TENLSTYALV | GHSTTKAAAK | RLKLAIFGPL | CCSSLEYSIR | 
    750:
    VYCLDDTQDA | LKEILHLERQ | MGGQLLEEPK | ALHFKGSTHN | LRLSIHDIAH | 
    800:
    SLWKSKLLAK | YQEIPFYHVW | SGSQRNLHCT | FTLERFSLNT | VELVCKLCVR | 
    850:
    QVEGEGQIFQ | LNCTVSEEPT | GIDLPLLDPA | NTITTVTGPS | AFSIPLPIRQ | 
    900:
    KLCSSLDAPQ | TRGHDWRMLA | HKLNLDRYLN | YFATKSSPTG | VILDLWEAQN | 
    931:
    FPDGNLSMLA | AVLEEMGRHE | TVVSLAAEGQ | Y
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Netrin receptor UNC5C
    Cat.:
    E7813h
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    Packing:
    96T
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    ELISA Kit for Human Netrin receptor UNC5C
    MSDS:
    Please sign in first.
    ELISA Kit for Human Netrin receptor UNC5C
    Cat.:
    E7813m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Netrin receptor UNC5C
    Cat.:
    E7813r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin receptor UNC5C
    Cat.:
    U7813r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin receptor UNC5C
    MSDS:
    Please sign in first.
    CLIA Kit for Human Netrin receptor UNC5C
    Cat.:
    U7813h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Netrin receptor UNC5C
    Cat.:
    U7813m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Netrin receptor UNC5C
    Polyclonal Antibody for Human Netrin receptor UNC5C
    Cat.:
    P7813Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Netrin receptor UNC5C
    Cat.:
    P7813Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Netrin receptor UNC5C
    Monoclonal Antibody for Human Netrin receptor UNC5C
    Monoclonal Antibody for Human Netrin receptor UNC5C
    Monoclonal Antibody for Human Netrin receptor UNC5C
    Monoclonal Antibody for Human Netrin receptor UNC5C
    Protein for Human Netrin receptor UNC5C
    Protein for Human Netrin receptor UNC5C
    Protein for Human Netrin receptor UNC5C
    Protein for Human Netrin receptor UNC5C

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    References
    1. 1.
      "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23."
      Ackerman S.L. , Knowles B.B.
      Genomics52:205-208(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT THR-721
      tissue: Brain.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lung.
    4. 4.
      "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment."
      Thiebault K. , Mazelin L. , Pays L. , Llambi F. , Joly M.-O. , Scoazec J.-Y. , Saurin J.-C. , Romeo G. , Mehlen P.
      Proc. Natl. Acad. Sci. U.S.A.100:4173-4178(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION IN CANCER
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