Gene name:
UNC5C (UNC5H3) ;
Protein name:
Netrin receptor UNC5C ;
Alternative:
Protein unc-5 homolog C ;Protein unc-5 homolog 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with the cytoplasmic part of DCC.
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MRKGLRATAA | RCGLGLGYLL | QMLVLPALAL | LSASGTGSAA | QDDDFFHELP |
100:
ETFPSDPPEP | LPHFLIEPEE | AYIVKNKPVN | LYCKASPATQ | IYFKCNSEWV |
150:
HQKDHIVDER | VDETSGLIVR | EVSIEISRQQ | VEELFGPEDY | WCQCVAWSSA |
200:
GTTKSRKAYV | RIAYLRKTFE | QEPLGKEVSL | EQEVLLQCRP | PEGIPVAEVE |
250:
WLKNEDIIDP | VEDRNFYITI | DHNLIIKQAR | LSDTANYTCV | AKNIVAKRKS |
300:
TTATVIVYVN | GGWSTWTEWS | VCNSRCGRGY | QKRTRTCTNP | APLNGGAFCE |
350:
GQSVQKIACT | TLCPVDGRWT | PWSKWSTCGT | ECTHWRRREC | TAPAPKNGGK |
400:
DCDGLVLQSK | NCTDGLCMQT | APDSDDVALY | VGIVIAVIVC | LAISVVVALF |
450:
VYRKNHRDFE | SDIIDSSALN | GGFQPVNIKA | ARQDLLAVPP | DLTSAAAMYR |
500:
GPVYALHDVS | DKIPMTNSPI | LDPLPNLKIK | VYNTSGAVTP | QDDLSEFTSK |
550:
LSPQMTQSLL | ENEALSLKNQ | SLARQTDPSC | TAFGSFNSLG | GHLIVPNSGV |
600:
SLLIPAGAIP | QGRVYEMYVT | VHRKETMRPP | MDDSQTLLTP | VVSCGPPGAL |
650:
LTRPVVLTMH | HCADPNTEDW | KILLKNQAAQ | GQWEDVVVVG | EENFTTPCYI |
700:
QLDAEACHIL | TENLSTYALV | GHSTTKAAAK | RLKLAIFGPL | CCSSLEYSIR |
750:
VYCLDDTQDA | LKEILHLERQ | MGGQLLEEPK | ALHFKGSTHN | LRLSIHDIAH |
800:
SLWKSKLLAK | YQEIPFYHVW | SGSQRNLHCT | FTLERFSLNT | VELVCKLCVR |
850:
QVEGEGQIFQ | LNCTVSEEPT | GIDLPLLDPA | NTITTVTGPS | AFSIPLPIRQ |
900:
KLCSSLDAPQ | TRGHDWRMLA | HKLNLDRYLN | YFATKSSPTG | VILDLWEAQN |
931:
FPDGNLSMLA | AVLEEMGRHE | TVVSLAAEGQ | Y
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
ELISA Kit for Human Netrin receptor UNC5C
ELISA Kit for Human Netrin receptor UNC5C
ELISA Kit for Human Netrin receptor UNC5C
ELISA Kit for Human Netrin receptor UNC5C
CLIA Kit for Human Netrin receptor UNC5C
CLIA Kit for Human Netrin receptor UNC5C
CLIA Kit for Human Netrin receptor UNC5C
CLIA Kit for Human Netrin receptor UNC5C
Polyclonal Antibody for Human Netrin receptor UNC5C
Polyclonal Antibody for Human Netrin receptor UNC5C
Polyclonal Antibody for Human Netrin receptor UNC5C
Polyclonal Antibody for Human Netrin receptor UNC5C
Monoclonal Antibody for Human Netrin receptor UNC5C
Monoclonal Antibody for Human Netrin receptor UNC5C
Monoclonal Antibody for Human Netrin receptor UNC5C
Monoclonal Antibody for Human Netrin receptor UNC5C
Protein for Human Netrin receptor UNC5C
Protein for Human Netrin receptor UNC5C
Protein for Human Netrin receptor UNC5C
Protein for Human Netrin receptor UNC5C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT THR-721
tissue :
Brain .
2.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Lung .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOWN-REGULATION IN CANCER