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Index > Protein center > PLAUR(Gene name) > Human
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  • PLAUR (Gene name),
  • Urokinase plasminogen activator surface receptor (Protein name ),  UPAR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PLAUR(MO3;UPAR);
    Protein name:
    Urokinase plasminogen activator surface receptor(U-PAR;uPAR);
    Alternative:
    Monocyte activation antigen Mo3;
    CD:
    CD87;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2.
    Function:
    Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    335
    Sequence:
    50:
    MGHPPLLPLL | LLLHTCVPAS | WGLRCMQCKT | NGDCRVEECA | LGQDLCRTTI | 
    100:
    VRLWEEGEEL | ELVEKSCTHS | EKTNRTLSYR | TGLKITSLTE | VVCGLDLCNQ | 
    150:
    GNSGRAVTYS | RSRYLECISC | GSSDMSCERG | RHQSLQCRSP | EEQCLDVVTH | 
    200:
    WIQEGEEGRP | KDDRHLRGCG | YLPGCPGSNG | FHNNDTFHFL | KCCNTTKCNE | 
    250:
    GPILELENLP | QNGRQCYSCK | GNSTHGCSSE | ETFLIDCRGP | MNQCLVATGT | 
    300:
    HEPKNQSYMV | RGCATASMCQ | HAHLGDAFSM | NHIDVSCCTK | SGCNHPDLDV | 
    335:
    QYRSGAAPQP | GPAHLSLTIT | LLMTARLWGG | TLLWT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human U-PAR
    Cat.:
    E0141h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human U-PAR
    Cat.:
    E0141m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human U-PAR
    Cat.:
    E0141r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human U-PAR
    Cat.:
    E0141b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human U-PAR
    Cat.:
    U0141m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-PAR
    Cat.:
    U0141h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-PAR
    Cat.:
    U0141b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-PAR
    Cat.:
    U0141r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human U-PAR
    Cat.:
    P0141Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human U-PAR
    Polyclonal Antibody for Human U-PAR
    Cat.:
    P0141Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human U-PAR
    Cat.:
    P0141Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human U-PAR
    Monoclonal Antibody for Human U-PAR
    Monoclonal Antibody for Human U-PAR
    Monoclonal Antibody for Human U-PAR
    Protein for Human U-PAR
    Protein for Human U-PAR
    Protein for Human U-PAR
    Protein for Human U-PAR

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis."
      Roldan A.L. , Cubellis M.V. , Masucci M.T. , Behrendt N. , Lund L.R. , Danoe K. , Appella E. , Blasi F.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 23-33
    2. 2.
      "cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator."
      Min H.Y. , Semnani R. , Mizukami I.F. , Watt K. , Todd R.F. III , Liu D.Y.
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    3. 3.
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    4. 4.
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      FEBS Lett.326:69-74(1993) [PubMed] [Europe PMC] [Abstract]
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    5. 5.
      "The structure of the urokinase-type plasminogen activator receptor gene."
      Casey J.R. , Petranka J.G. , Kottra J. , Fleenor D.E. , Rosse W.F.
      Blood84:1151-1156(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3)
      tissue: Placenta.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-55; ALA-86; GLN-105; ARG-220; LYS-281 AND PRO-317
    9. 9.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
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    10. 10.
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    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    12. 12.
      "cDNA cloning and sequencing of human urokinase receptor."
      Zhu F. , Jia S. , He F.
      Sheng Wu Gong Cheng Xue Bao16:461-463(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-322 (ISOFORM 1)
      tissue: Lung cancer.
    13. 13.
      "Experimental study of anti-metastatic effect of soluble receptor for urokinase plasminogen activator on human breast cancer cells."
      Fu J. , Bai X. , Wang W. , Xi X. , Ruan C.
      Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-301 (ISOFORM 1)
    14. 14.
      "A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene."
      Soravia E. , Grebe A. , De Luca P. , Helin K. , Suh T.T. , Degen J.L. , Blasi F.
      Blood86:624-635(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18
    15. 15.
      "The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants."
      Behrendt N. , Roenne E. , Ploug M. , Petri T. , Loeber D. , Nielsen L.S. , Schleuning W.-D. , Blasi F. , Appella E. , Danoe K.
      J. Biol. Chem.265:6453-6460(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
    16. 16.
      "Cell-surface acceleration of urokinase-catalyzed receptor cleavage."
      Hoeyer-Hansen G. , Ploug M. , Behrendt N. , Roenne E. , Danoe K.
      Eur. J. Biochem.243:21-26(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 106-116;CLEAVAGE BY U-PA
    17. 17.
      "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."
      Duke-Cohan J.S. , Morimoto C. , Rocker J.A. , Schlossman S.F.
      J. Biol. Chem.270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 210-230 (ISOFORMS 1/2/3)
      tissue: Serum.
    18. 18.
      "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins."
      Ploug M. , Kjalke M. , Roenne E. , Weidle U. , Hoeyer-Hansen G. , Danoe K.
      J. Biol. Chem.268:17539-17546(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;PARTIAL PROTEIN SEQUENCE
    19. 19.
      "A urokinase receptor-associated protein with specific collagen binding properties."
      Behrendt N. , Jensen O.N. , Engelholm L.H. , Moertz E. , Mann M. , Danoe K.
      J. Biol. Chem.275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRC2
    20. 20.
      "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton."
      Artym V.V. , Kindzelskii A.L. , Chen W.T. , Petty H.R.
      Carcinogenesis23:1593-1601(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAP;SUBCELLULAR LOCATION
    21. 21.
      "Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
      Elortza F. , Nuehse T.S. , Foster L.J. , Stensballe A. , Peck S.C. , Jensen O.N.
      Mol. Cell. Proteomics2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."
      Zhu Y. , Bujo H. , Yamazaki H. , Ohwaki K. , Jiang M. , Hirayama S. , Kanaki T. , Shibasaki M. , Takahashi K. , Schneider W.J. , Saito Y.
      Circ. Res.94:752-758(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORL1
    23. 23.
      "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
      Elortza F. , Mohammed S. , Bunkenborg J. , Foster L.J. , Nuehse T.S. , Brodbeck U. , Peck S.C. , Jensen O.N.
      J. Proteome Res.5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    24. 24.
      "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."
      Royer-Zemmour B. , Ponsole-Lenfant M. , Gara H. , Roll P. , Leveque C. , Massacrier A. , Ferracci G. , Cillario J. , Robaglia-Schlupp A. , Vincentelli R. , Cau P. , Szepetowski P.
      Hum. Mol. Genet.17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRPX2
    25. 25.
      "Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide."
      Llinas P. , Le Du M.H. , Gaardsvoll H. , Danoe K. , Ploug M. , Gilquin B. , Stura E.A. , Menez A.
      EMBO J.24:1655-1663(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 23-335 OF MUTANT GLN-222 IN COMPLEX WITH PEPTIDE ANTAGONIST;GLYCOSYLATION AT ASN-74; ASN-184; ASN-194 AND ASN-255;DISULFIDE BONDS
    26. 26.
      "Structure of human urokinase plasminogen activator in complex with its receptor."
      Huai Q. , Mazar A.P. , Kuo A. , Parry G.C. , Shaw D.E. , Callahan J. , Li Y. , Yuan C. , Bian C. , Chen L. , Furie B. , Furie B.C. , Cines D.B. , Huang M.
      Science311:656-659(2006) [PubMed] [Europe PMC] [Abstract]
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