Protein name:
Vitamin D3 receptor (VDR) ;
Alternative:
Nuclear receptor subfamily 1 group I member 1 ;1,25-dihydroxyvitamin D3 receptor ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.
Function:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MEATAASTSL | PDPGDFDRNV | PRICGVCGDR | ATGFHFNAMT | CEGCKGFFRR |
100:
SMKRKALFTC | PFNGDCRITK | DNRRHCQACR | LKRCVDIGMM | KEFILTDEEV |
150:
QRKREMIMKR | KEEEALKDSL | RPKLSEEQQH | IIAILLDAHH | KTYDPTYADF |
200:
RDFRPPVRMD | GSTGSYSPRP | TLSFSGNSSS | SSSDLYTTSL | DMMEPSGFSN |
250:
LDLNGEDSDD | PSVTLDLSPL | SMLPHLADLV | SYSIQKVIGF | AKMIPGFRDL |
300:
TSDDQIVLLK | SSAIEVIMLR | SNQSFTMDDM | SWDCGSQDYK | YDVTDVSKAG |
350:
HTLELIEPLI | KFQVGLKKLN | LHEEEHVLLM | AICIVSPDRP | GVQDAKLVEA |
400:
IQDRLSNTLQ | TYIRCRHPPP | GSHQLYAKMI | QKLADLRSLN | EEHSKQYRSL |
423:
SFQPENSMKL | TPLVLEVFGN | EIS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Pig
Chicken
Polyclonal Antibody for Rat VDR
Polyclonal Antibody for Rat VDR
Polyclonal Antibody for Rat VDR
Polyclonal Antibody for Rat VDR
Polyclonal Antibody for Rat VDR
Polyclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
Monoclonal Antibody for Rat VDR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 58-423
tissue :
Kidney .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NCOA6
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 116-423 IN COMPLEXES WITH VITAMIN D3 ANALOGS AND MED1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 116-423 IN COMPLEXES WITH VITAMIN D3 ANALOGS AND MED1;FUNCTION