Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > VHL(Gene name) > Human
  • Add your favorite
  • VHL (Gene name),
  • Von Hippel-Lindau disease tumor suppressor (Protein name ),  VHL_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    VHL;
    Protein name:
    Von Hippel-Lindau disease tumor suppressor;
    Alternative:
    pVHL;Protein G7;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiqitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with RNF139 and USP33. Interacts with PHF17.
    Function:
    Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
    Subcellular Location:
    Isoform 3 Cytoplasm Nucleus Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
    Protein Attributes:
    Sequence length:
    213
    Sequence:
    50:
    MPRRAENWDE | AEVGAEEAGV | EEYGPEEDGG | EESGAEESGP | EESGPEELGA | 
    100:
    EEEMEAGRPR | PVLRSVNSRE | PSQVIFCNRS | PRVVLPVWLN | FDGEPQPYPT | 
    150:
    LPPGTGRRIH | SYRGHLWLFR | DAGTHDGLLV | NQTELFVPSL | NVDGQPIFAN | 
    200:
    ITLPVYTLKE | RCLQVVRSLV | KPENYRRLDI | VRSLYEDLED | HPNVQKDLER | 
    213:
    LTQERIAHQR | MGD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    E1894h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    E1894r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    E1894m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    E1894d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    U1894d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    U1894h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    U1894m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    U1894r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    P1894Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Polyclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    P1894Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Cat.:
    P1894Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Monoclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Monoclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Monoclonal Antibody for Human Von Hippel-Lindau disease tumor suppressor
    Protein for Human Von Hippel-Lindau disease tumor suppressor
    Protein for Human Von Hippel-Lindau disease tumor suppressor
    Protein for Human Von Hippel-Lindau disease tumor suppressor
    Protein for Human Von Hippel-Lindau disease tumor suppressor

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANTS VHLD ILE-75 DEL AND ARG-82--84-VAL DEL;ALTERNATIVE SPLICING (ISOFORM 2)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT TYR-110
    6. 6.
      Wenzel M.
      Submitted (1996-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-67 AND 156-213;VARIANT PRO-163
      tissue: Renal cell carcinoma.
    7. 7.
      "Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis."
      Richards F.M. , Schofield P.N. , Fleming S. , Maher E.R.
      Hum. Mol. Genet.5:639-644(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
    8. 8.
      "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins."
      Pause A. , Lee S. , Worrel R. , Chen D.Y.T. , Burgess W.H. , Linehan W.M. , Klausner R.D.
      Proc. Natl. Acad. Sci. U.S.A.94:2156-2161(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CUL2
    9. 9.
      "A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor."
      Schoenfeld A. , Davidowitz E.J. , Burk R.D.
      Proc. Natl. Acad. Sci. U.S.A.95:8817-8822(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 3)
    10. 10.
      "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C."
      Kibel A. , Iliopoulos O. , DeCaprio J.A. , Kaelin W.G. Jr.
      Science269:1444-1446(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELONGIN BC COMPLEX
    11. 11.
      "pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation."
      Iliopoulos O. , Ohh M. , Kaelin W.G. Jr.
      Proc. Natl. Acad. Sci. U.S.A.95:11661-11666(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 3);SUBCELLULAR LOCATION
    12. 12.
      "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC."
      Feldman D.E. , Thulasiraman V. , Ferreyra R.G. , Frydman J.
      Mol. Cell4:1051-1061(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHAPERONES;VARIANT VHLD PRO-158
    13. 13.
      "Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein."
      Tanimoto K. , Makino Y. , Pereira T. , Poellinger L.
      EMBO J.19:4298-4309(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIF1A;FUNCTION;CHARACTERIZATION OF VARIANT PHE-162;MUTAGENESIS OF TYR-98
    14. 14.
      "Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase."
      Kamura T. , Burian D. , Yan Q. , Schmidt S.L. , Lane W.S. , Querido E. , Branton P.E. , Shilatifard A. , Conaway R.C. , Conaway J.W.
      J. Biol. Chem.276:29748-29753(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES
    15. 15.
      "FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity."
      Mahon P.C. , Hirota K. , Semenza G.L.
      Genes Dev.15:2675-2686(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIF1AN; HIF1A AND HISTONE DEACETYLASES
      tissue: Brain.
    16. 16.
      "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein."
      Li Z. , Na X. , Wang D. , Schoen S.R. , Messing E.M. , Wu G.
      J. Biol. Chem.277:4656-4662(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP33
    17. 17.
      "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
      Zhou M.I. , Wang H. , Ross J.J. , Kuzmin I. , Xu C. , Cohen H.T.
      J. Biol. Chem.277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JADE1
    18. 18.
      "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway."
      Gemmill R.M. , Bemis L.T. , Lee J.P. , Sozen M.A. , Baron A. , Zeng C. , Erickson P.F. , Hooper J.E. , Drabkin H.A.
      Oncogene21:3507-3516(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF139
    19. 19.
      "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia."
      Cheng J. , Kang X. , Zhang S. , Yeh E.T.H.
      Cell131:584-595(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIF1A
    20. 20.
      "Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline."
      Furlow P.W. , Percy M.J. , Sutherland S. , Bierl C. , McMullin M.F. , Master S.R. , Lappin T.R. , Lee F.S.
      J. Biol. Chem.284:9050-9058(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPAS1
    21. 21.
      "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL."
      Xie L. , Xiao K. , Whalen E.J. , Forrester M.T. , Freeman R.S. , Fong G. , Gygi S.P. , Lefkowitz R.J. , Stamler J.S.
      Sci. Signal.2:RA33-RA33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADRB2;SUBCELLULAR LOCATION;FUNCTION
    22. 22.
      "The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."
      Foxler D.E. , Bridge K.S. , James V. , Webb T.M. , Mee M. , Wong S.C. , Feng Y. , Constantin-Teodosiu D. , Petursdottir T.E. , Bjornsson J. , Ingvarsson S. , Ratcliffe P.J. , Longmore G.D. , Sharp T.V.
      Nat. Cell Biol.14:201-208(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIMD1; AJUBA AND WTIP;IDENTIFICATION IN A COMPLEX WITH LIMD1; EGLN1/PHD2; TCEB2 AND CUL2
    23. 23.
      "Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."
      Min J.-H. , Yang H. , Ivan M. , Gertler F. , Kaelin W.G. Jr. , Pavletich N.P.
      Science296:1886-1889(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 54-213 IN COMPLEX WITH 556-575 OF HIF1A; TCEB1 AND TCEB2
    24. 24.
      "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL."
      Hon W.-C. , Wilson M.I. , Harlos K. , Claridge T.D.W. , Schofield C.J. , Pugh C.W. , Maxwell P.H. , Ratcliffe P.J. , Stuart D.I. , Jones E.Y.
      Nature417:975-978(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 52-213 IN COMPLEX WITH 549-582 OF HIF1A; 17-112 OF TCEB1 AND TCEB2
    25. 25.
      "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function."
      Stebbins C.E. , Kaelin W.G. Jr. , Pavletich N.P.
      Science284:455-461(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 54-213 IN COMPLEX WITH 17-112 OF TCEB1 AND TCEB2
    26. 26.
      "Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas."
      Kanno H. , Kondo K. , Ito S. , Yamamoto I. , Fujii S. , Torigoe S. , Sakai N. , Hosaka M. , Shuin T. , Yao M.
      Cancer Res.54:4845-4847(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HEMANGIOBLASTOMA PHE-135
    27. 27.
      "Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines."
      Sekido Y. , Bader S. , Latif F. , Gnarra J.R. , Gazdar A.F. , Linehan W.M. , Zbar B. , Lerman M.I. , Minna J.D.
      Oncogene9:1599-1604(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IN LUNG CANCER
    28. 28.
      "Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype."
      Crossey P.A. , Richards F.M. , Foster K. , Green J.S. , Prowse A. , Latif F. , Lerman M.I. , Zbar B. , Affara N.A. , Ferguson-Smith M.A. , Maher E.R.
      Hum. Mol. Genet.3:1303-1308(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD
    29. 29.
      "Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype."
      Chen F. , Kishida T. , Yao M. , Hustad T. , Glavac D. , Dean M. , Gnarra J.R. , Orcutt M.L. , Duh F.-M. , Glenn G. , Green J.S. , Hsia Y.E. , Lamiell J. , Li H. , Wei M.H. , Schmidt L. , Tory K. , Kuzmin I. , more...
      Hum. Mutat.5:66-75(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD
    31. 31.
      "Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma."
      Crossey P.A. , Eng C. , Ginalska-Malinowska M. , Lennard T.W.J. , Wheeler D.C. , Ponder B.A.J. , Maher E.R.
      J. Med. Genet.32:885-886(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD LEU-84 AND TRP-167
    32. 32.
      "Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas."
      Eng C. , Crossey P.A. , Mulligan L.M. , Healey C.S. , Houghton C. , Prowse A. , Chew S.L. , Dahia P.L.M. , O'Riordan J.L.H. , Toledo S.P.A. , Smith D.P. , Maher E.R. , Ponder B.A.J.
      J. Med. Genet.32:934-937(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD SER-114; SER-119; GLU-143 AND ARG-164
    33. 33.
      "Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations."
      Maher E.R. , Webster A.R. , Richards F.M. , Green J.S. , Crossey P.A. , Payne S.J. , Moore A.T.
      J. Med. Genet.33:328-332(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD PRO-96; VAL-116; ARG-118; PHE-166; ASP-170 AND GLU-186 DEL
    34. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD LEU-65; TRP-65; GLY-74; PHE-76 DEL; ILE-76; HIS-78; SER-78; THR-78; ARG-80; ASN-80; ILE-80; SER-81; ALA-86; LEU-86; ARG-88; SER-88; PRO-89; ARG-101; ARG-111; ASN-111; CYS-114; TYR-115; CYS-117; PRO-118; GLY-121; LEU-130; PRO-158; VAL-158; PRO-161; ARG-162; PHE-162; TYR-162; TRP-162; ARG-164; GLN-167; TRP-167; GLY-170; PRO-178; VAL-180; ARG-184; PRO-184; LYS-186; GLN-188 AND TRP-200
    35. 35.
      "Germline mutations detected in the von Hippel-Lindau disease tumor suppressor gene by Southern blot and direct genomic DNA sequencing."
      Li C. , Weber G. , Ekman P. , Lagercrantz J. , Norlen B.J. , Aakerstroem G. , Nordenskjoeld M. , Bergerheim U.S.R.
      Hum. Mutat. Suppl.1:S31-S33(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD PRO-38; LEU-76 AND PHE-162
    36. 36.
      "Three novel mutations in the von Hippel-Lindau tumour suppressor gene in Italian patients."
      Mandich P. , Montera M. , Bellone E. , Trojani A. , Daniele S. , Ajmar F.
      Hum. Mutat. Suppl.1:S268-S270(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VHLD THR-149
    37. 37.
      "Variable penetrance of familial pheochromocytoma associated with the von Hippel-Lindau gene mutation, S68W."
      Martin R. , Hockey A. , Walpole I. , Goldblatt J.
      Hum. Mutat.12:71-71(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VHLD TRP-68
    38. 38.
      "Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene."
      Stolle C. , Glenn G. , Zbar B. , Humphrey J.S. , Choyke P. , Walther M. , Pack S. , Hurley K. , Andrey C. , Klausner R. , Linehan W.M.
      Hum. Mutat.12:417-423(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD TRP-65; SER-76; SER-81; ARG-86; ARG-88; GLY-101; PRO-107; ASN-111; CYS-117; THR-131; PHE-162; GLY-167; ASP-175; PRO-184 AND LYS-186
    39. 39.
      "Germline mutation profile of the VHL gene in von Hippel-Lindau disease and in sporadic hemangioblastoma."
      Olschwang S. , Richard S. , Boisson C. , Giraud S. , Laurent-Puig P. , Resche F. , Thomas G.
      Hum. Mutat.12:424-430(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD LYS-52; LEU-65; LYS-70; ASN-80; ARG-80; SER-86; SER-88; LEU-91; ALA-104; PRO-105; GLN-115; CYS-117; PRO-118; LEU-130; LYS-131; SER-136; ASP-156; CYS-156; ILE-157; PRO-158; GLN-161; TRP-162; PHE-166; GLN-167; TRP-167; GLY-170; PRO-188 AND TRP-200
    40. 40.
      "Germline mutations in the vhl gene in patients presenting with phaeochromocytomas."
      van der Harst E. , de Krijger R.R. , Dinjens W.N.M. , Weeks L.E. , Bonjer H.J. , Bruining H.A. , Lamberts S.W.J. , Koper J.W.
      Int. J. Cancer77:337-340(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHEOCHROMOCYTOMA LEU-25; PRO-63; PRO-64 AND THR-147
    41. 41.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD CYS-93; GLY-155 AND ILE-157
    42. 42.
      "Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene."
      Bradley J.F. , Collins D.L. , Schimke R.N. , Parrott H.N. , Rothberg P.G.
      Am. J. Med. Genet.87:163-167(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VHLD ASN-112
    43. 43.
      "Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC."
      Gallou C. , Joly D. , Mejean A. , Staroz F. , Martin N. , Tarlet G. , Orfanelli M.T. , Bouvier R. , Droz D. , Chretien Y. , Marechal J.M. , Richard S. , Junien C. , Beroud C.
      Hum. Mutat.13:464-475(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VHLD
    44. 44.
      "Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma."
      Wiesener M.S. , Seyfarth M. , Warnecke C. , Juergensen J.S. , Rosenberger C. , Morgan N.V. , Maher E.R. , Frei U. , Eckardt K.-U.
      Blood99:3562-3565(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RCC PRO-163;CHARACTERIZATION OF VARIANT RCC PRO-163
    45. 45.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHEOCHROMOCYTOMA ALA-65; TRP-68; ASN-80; SER-93; CYS-93; HIS-98; GLY-107; LEU-119; ILE-122; CYS-136; ASN-156; CYS-156; GLN-161; PRO-161; TRP-167; GLN-167; VAL-188 AND GLN-198
    46. 46.
      "Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia."
      Pastore Y.D. , Jedlickova K. , Guan Y. , Liu E. , Fahner J. , Hasle H. , Prchal J.F. , Prchal J.T.
      Am. J. Hum. Genet.73:412-419(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT2 VAL-188; ASP-191; SER-192 AND TRP-200
    47. 47.
      "Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas."
      Gimenez-Roqueplo A.-P. , Favier J. , Rustin P. , Rieubland C. , Crespin M. , Nau V. , Khau Van Kien P. , Corvol P. , Plouin P.-F. , Jeunemaitre X.
      Cancer Res.63:5615-5621(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHEOCHROMOCYTOMA LEU-25 AND CYS-156
    48. 48.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    49. 49.
      "Mutations in the VHL gene in sporadic apparently congenital polycythemia."
      Pastore Y.D. , Jelinek J. , Ang S. , Guan Y. , Liu E. , Jedlickova K. , Krishnamurti L. , Prchal J.T.
      Blood101:1591-1595(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT2 TYR-126; LEU-130 AND TRP-200
    50. 50.
      "The von Hippel-Lindau (VHL) germline mutation V84L manifests as early-onset bilateral pheochromocytoma."
      Abbott M.-A. , Nathanson K.L. , Nightingale S. , Maher E.R. , Greenstein R.M.
      Am. J. Med. Genet. A140:685-690(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VHLD LEU-84
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter