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Index > Protein center > HDLBP(Gene name) > Human
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  • HDLBP (Gene name),
  • Vigilin (Protein name ),  VIGLN_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
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  • Predicted Eptitope
  • |
  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    HDLBP(HBP;VGL);
    Protein name:
    Vigilin;
    Alternative:
    High density lipoprotein-binding protein(HDL-binding protein);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    1268
    Sequence:
    50:
    MSSVAVLTQE | SFAEHRSGLV | PQQIKVATLN | SEEESDPPTY | KDAFPPLPEK | 
    100:
    AACLESAQEP | SGAWGNKIRP | IKASVITQVF | HVPLEERKYK | DMNQFGEGEQ | 
    150:
    AKICLEIMQR | TGAHLELSLA | KDQGLSIMVS | GKLDAVMKAR | KDIVARLQTQ | 
    200:
    ASATVAIPKE | HHRFVIGKNG | EKLQDLELKT | ATKIQIPRPD | DPSNQIKITG | 
    250:
    TKEGIEKARH | EVLLISAEQD | KRAVERLEVE | KAFHPFIAGP | YNRLVGEIMQ | 
    300:
    ETGTRINIPP | PSVNRTEIVF | TGEKEQLAQA | VARIKKIYEE | KKKKTTTIAV | 
    350:
    EVKKSQHKYV | IGPKGNSLQE | ILERTGVSVE | IPPSDSISET | VILRGEPEKL | 
    400:
    GQALTEVYAK | ANSFTVSSVA | APSWLHRFII | GKKGQNLAKI | TQQMPKVHIE | 
    450:
    FTEGEDKITL | EGPTEDVNVA | QEQIEGMVKD | LINRMDYVEI | NIDHKFHRHL | 
    500:
    IGKSGANINR | IKDQYKVSVR | IPPDSEKSNL | IRIEGDPQGV | QQAKRELLEL | 
    550:
    ASRMENERTK | DLIIEQRFHR | TIIGQKGERI | REIRDKFPEV | IINFPDPAQK | 
    600:
    SDIVQLRGPK | NEVEKCTKYM | QKMVADLVEN | SYSISVPIFK | QFHKNIIGKG | 
    650:
    GANIKKIREE | SNTKIDLPAE | NSNSETIIIT | GKRANCEAAR | SRILSIQKDL | 
    700:
    ANIAEVEVSI | PAKLHNSLIG | TKGRLIRSIM | EECGGVHIHF | PVEGSGSDTV | 
    750:
    VIRGPSSDVE | KAKKQLLHLA | EEKQTKSFTV | DIRAKPEYHK | FLIGKGGGKI | 
    800:
    RKVRDSTGAR | VIFPAAEDKD | QDLITIIGKE | DAVREAQKEL | EALIQNLDNV | 
    850:
    VEDSMLVDPK | HHRHFVIRRG | QVLREIAEEY | GGVMVSFPRS | GTQSDKVTLK | 
    900:
    GAKDCVEAAK | KRIQEIIEDL | EAQVTLECAI | PQKFHRSVMG | PKGSRIQQIT | 
    950:
    RDFSVQIKFP | DREENAVHST | EPVVQENGDE | AGEGREAKDC | DPGSPRRCDI | 
    1000:
    IIISGRKEKC | EAAKEALEAL | VPVTIEVEVP | FDLHRYVIGQ | KGSGIRKMMD | 
    1050:
    EFEVNIHVPA | PELQSDIIAI | TGLAANLDRA | KAGLLERVKE | LQAEQEDRAL | 
    1100:
    RSFKLSVTVD | PKYHPKIIGR | KGAVITQIRL | EHDVNIQFPD | KDDGNQPQDQ | 
    1150:
    ITITGYEKNT | EAARDAILRI | VGELEQMVSE | DVPLDHRVHA | RIIGARGKAI | 
    1200:
    RKIMDEFKVD | IRFPQSGAPD | PNCVTVTGLP | ENVEEAIDHI | LNLEEEYLAD | 
    1250:
    VVDSEALQVY | MKPPAHEEAK | APSRGFVVRD | APWTASSSEK | APDMSSSEEF | 
    1268:
    PSFGAQVAPK | TLPWGPKR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vigilin
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    E9714m
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    ELISA Kit for Human Vigilin
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    ELISA Kit for Human Vigilin
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    ELISA Kit for Human Vigilin
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    CLIA Kit for Human Vigilin
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    CLIA Kit for Human Vigilin
    Cat.:
    U9714h
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    MSDS:
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    Packing:
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    CLIA Kit for Human Vigilin
    Cat.:
    U9714r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Vigilin
    Cat.:
    U9714m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Vigilin
    Polyclonal Antibody for Human Vigilin
    Cat.:
    P9714Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vigilin
    Cat.:
    P9714Rb-h
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vigilin
    Monoclonal Antibody for Human Vigilin
    Monoclonal Antibody for Human Vigilin
    Monoclonal Antibody for Human Vigilin
    Monoclonal Antibody for Human Vigilin
    Protein for Human Vigilin
    Protein for Human Vigilin
    Protein for Human Vigilin
    Protein for Human Vigilin

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    References
    1. 1.
      "Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells."
      McKnight G.L. , Reasoner J. , Gilbert T. , Sundquist K.O. , Hokland B. , McKernan P.A. , Champagne J. , Johnson C.J. , Bailey M.C. , Holly R. , O'Hara P.J. , Oram J.F.
      J. Biol. Chem.267:12131-12141(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-61
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-61
      tissue: Placenta.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-61
      tissue: Muscle.
    5. 5.
      Bienvenut W.V. , Matallanas D. , Cooper W.N. , Kolch W. , Glen H. , Frame M.C.
      Submitted (2008-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-16; 73-87; 147-159; 208-222; 232-283; 315-324; 350-377; 483-494; 496-503; 535-557; 649-663; 902-908 AND 1120-1137;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Mammary carcinoma.
      tissue: Osteosarcoma.
    6. 6.
      "Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus."
      Kugler S. , Grunweller A. , Probst C. , Klinger M. , Mueller P.K. , Kruse C.
      FEBS Lett.382:330-334(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-437;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Solution structure of the 1st, 4th, 8th, 12th, 13th and 14th KH type-I domains from human vigilin."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 142-222; 345-434; 645-727 AND 964-1200
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-568 AND VAL-939
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-61;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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