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Index > Protein center > VLDLR(Gene name) > Human
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  • VLDLR (Gene name),
  • Very low-density lipoprotein receptor (Protein name ),  VLDLR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VLDLR;
    Protein name:
    Very low-density lipoprotein receptor(VLDL receptor;VLDL-R);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains.
    Function:
    Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    873
    Sequence:
    50:
    MGTSALWALW | LLLALCWAPR | ESGATGTGRK | AKCEPSQFQC | TNGRCITLLW | 
    100:
    KCDGDEDCVD | GSDEKNCVKK | TCAESDFVCN | NGQCVPSRWK | CDGDPDCEDG | 
    150:
    SDESPEQCHM | RTCRIHEISC | GAHSTQCIPV | SWRCDGENDC | DSGEDEENCG | 
    200:
    NITCSPDEFT | CSSGRCISRN | FVCNGQDDCS | DGSDELDCAP | PTCGAHEFQC | 
    250:
    STSSCIPISW | VCDDDADCSD | QSDESLEQCG | RQPVIHTKCP | ASEIQCGSGE | 
    300:
    CIHKKWRCDG | DPDCKDGSDE | VNCPSRTCRP | DQFECEDGSC | IHGSRQCNGI | 
    350:
    RDCVDGSDEV | NCKNVNQCLG | PGKFKCRSGE | CIDISKVCNQ | EQDCRDWSDE | 
    400:
    PLKECHINEC | LVNNGGCSHI | CKDLVIGYEC | DCAAGFELID | RKTCGDIDEC | 
    450:
    QNPGICSQIC | INLKGGYKCE | CSRGYQMDLA | TGVCKAVGKE | PSLIFTNRRD | 
    500:
    IRKIGLERKE | YIQLVEQLRN | TVALDADIAA | QKLFWADLSQ | KAIFSASIDD | 
    550:
    KVGRHVKMID | NVYNPAAIAV | DWVYKTIYWT | DAASKTISVA | TLDGTKRKFL | 
    600:
    FNSDLREPAS | IAVDPLSGFV | YWSDWGEPAK | IEKAGMNGFD | RRPLVTADIQ | 
    650:
    WPNGITLDLI | KSRLYWLDSK | LHMLSSVDLN | GQDRRIVLKS | LEFLAHPLAL | 
    700:
    TIFEDRVYWI | DGENEAVYGA | NKFTGSELAT | LVNNLNDAQD | IIVYHELVQP | 
    750:
    SGKNWCEEDM | ENGGCEYLCL | PAPQINDHSP | KYTCSCPSGY | NVEENGRDCQ | 
    800:
    STATTVTYSE | TKDTNTTEIS | ATSGLVPGGI | NVTTAVSEVS | VPPKGTSAAW | 
    850:
    AILPLLLLVM | AAVGGYLMWR | NWQHKNMKSM | NFDNPVYLKT | TEEDLSIDIG | 
    873:
    RHSASVGHTY | PAISVVSTDD | DLA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human VLDL receptor
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    ELISA Kit for Human VLDL receptor
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    ELISA Kit for Human VLDL receptor
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    ELISA Kit for Human VLDL receptor
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    ELISA Kit for Human VLDL receptor
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    CLIA Kit for Human VLDL receptor
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    CLIA Kit for Human VLDL receptor
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    CLIA Kit for Human VLDL receptor
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    U1009m
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    Polyclonal Antibody for Human VLDL receptor
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    P1009Rb-m
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    Polyclonal Antibody for Human VLDL receptor
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    Packing:
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    Polyclonal Antibody for Human VLDL receptor
    Polyclonal Antibody for Human VLDL receptor
    Polyclonal Antibody for Human VLDL receptor
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    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VLDL receptor
    Monoclonal Antibody for Human VLDL receptor
    Monoclonal Antibody for Human VLDL receptor
    Monoclonal Antibody for Human VLDL receptor
    Monoclonal Antibody for Human VLDL receptor
    Protein for Human VLDL receptor
    Protein for Human VLDL receptor
    Protein for Human VLDL receptor
    Protein for Human VLDL receptor
    Protein for Human VLDL receptor

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    Linearity
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    References
    1. 1.
      "Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23."
      Gafvels M.E. , Caird M. , Britt D. , Jackson C.L. , Patterson D. , Strauss J.F.
      Somat. Cell Mol. Genet.19:557-569(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
    2. 2.
      "Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA."
      Webb J.C. , Patel D.D. , Jones M.D. , Knight B.L. , Soutar A.K.
      Hum. Mol. Genet.3:531-537(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart.
    3. 3.
      "Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene."
      Sakai J. , Hoshino A. , Takahashi S. , Miura Y. , Ishii H. , Suzuki H. , Kawarabayasi Y. , Yamamoto T.
      J. Biol. Chem.269:2173-2182(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    4. 4.
      "Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization."
      Oka K. , Tzung K.W. , Sullivan M. , Lindsay E. , Baldini A. , Chan L.
      Genomics20:298-300(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-59; HIS-262; ILE-464; VAL-561; HIS-613 AND ILE-791
    6. 6.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
    9. 9.
      "A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid."
      Neumann E. , Moser R. , Snyers L. , Blaas D. , Hewat E.A.
      J. Virol.77:8504-8511(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRV VP1
    10. 10.
      "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."
      Poirier S. , Mayer G. , Benjannet S. , Bergeron E. , Marcinkiewicz J. , Nassoury N. , Mayer H. , Nimpf J. , Prat A. , Seidah N.G.
      J. Biol. Chem.283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PCSK9
    11. 11.
      "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
      Hong C. , Duit S. , Jalonen P. , Out R. , Scheer L. , Sorrentino V. , Boyadjian R. , Rodenburg K.W. , Foley E. , Korhonen L. , Lindholm D. , Nimpf J. , van Berkel T.J. , Tontonoz P. , Zelcer N.
      J. Biol. Chem.285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-839 BY MYLIP;GLYCOSYLATION;MUTAGENESIS OF LYS-825; LYS-828 AND LYS-839
    12. 12.
      "X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein."
      Verdaguer N. , Fita I. , Reithmayer M. , Moser R. , Blaas D.
      Nat. Struct. Mol. Biol.11:429-434(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 111-151 IN COMPLEX WITH HRV2
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-59 AND LYS-379
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    15. 15.
      "Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification."
      Boycott K.M. , Flavelle S. , Bureau A. , Glass H.C. , Fujiwara T.M. , Wirrell E. , Davey K. , Chudley A.E. , Scott J.N. , McLeod D.R. , Parboosingh J.S.
      Am. J. Hum. Genet.77:477-483(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CAMRQ1
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