VTCN1 ELISA Kit for Human(Homo sapiens) | EIAab.comVTCN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > VTCN1(Gene name) > Human

VTCN1 (Gene name),

V-set domain-containing T-cell activation inhibitor 1 (Protein name ), VTCN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

VTCN1(UNQ659/PRO1291;B7H4);

Protein name:

V-set domain-containing T-cell activation inhibitor 1;

Alternative:

Immune costimulatory protein B7-H4;B7h.5;T-cell costimulatory molecule B7x;Protein B7S1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Expressed at the cell surface. A soluble form has also been detected.

Protein Attributes:

Sequence length:

282

Sequence:

50:

100:

150:

200:

250:

282:

LQLLNSKASL | CVSSFFAISW | ALLPLSPYLM | LK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

MIM:

608162

SMR:

Q7Z7D3

STRING:

9606.ENSP00000358470

UniGene:

Hs.546434

String:

Q7Z7D3

KEGG:

hsa:79679

Uniprot:

Q7Z7D3

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ELISA Kit for Human V-set domain-containing T-cell activation inhibitor 1

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E1079h

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96T

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ELISA Kit for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

E1079m

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96T

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ELISA Kit for Human V-set domain-containing T-cell activation inhibitor 1

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E1079r

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96T

CLIA Kit for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

U1079m

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96T

CLIA Kit for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

U1079r

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Packing:

96T

CLIA Kit for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

U1079h

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96T

Polyclonal Antibody for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

P1079Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

P1079Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human V-set domain-containing T-cell activation inhibitor 1

Cat.:

P1079Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human V-set domain-containing T-cell activation inhibitor 1

Protein for Human V-set domain-containing T-cell activation inhibitor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Tumor expression of B7-H4 predicts poor survival of patients suVering from gastric cancer"

Jingting Jiang · Yibei Zhu · Changping Wu ·Yueping Shen · Wenxiang Wei · Lujun Chen · Xiao Zheng · Jing Sun · Binfeng Lu · Xueguang Zhang

From:Cancer Immunol Immunother

References

1.

"B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
Sica G.L. , Choi I.-H. , Zhu G. , Tamada K. , Wang S.-D. , Tamura H. , Chapoval A.I. , Flies D.B. , Bajorath J. , Chen L.
Immunity18:849-861(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Placenta.
2.

"B7x: a widely expressed B7 family member that inhibits T cell activation."
Zang X. , Loke P. , Kim J. , Murphy K. , Waitz R. , Allison J.P.
Proc. Natl. Acad. Sci. U.S.A.100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"B7-H3 and B7-H4 expression in non-small-cell lung cancer."
Sun Y. , Wang Y. , Zhao J. , Gu M. , Giscombe R. , Lefvert A.K. , Wang X.
Lung Cancer53:143-151(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.

"A new splice variant of B7-H4."
Mao Y. , Zhang X.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
5.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue: Kidney epithelium.
tissue: Thymus.
7.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue: Brain.
tissue: Prostate.
10.

Huang G. , Bai Y. , Zhang L. , Zhang L. , Song M.
Submitted (2006-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1)
tissue: Peripheral blood.
11.

"Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family."
Choi I.-H. , Zhu G. , Sica G.L. , Strome S.E. , Cheville J.C. , Lau J.S. , Zhu Y. , Flies D.B. , Tamada K. , Chen L.
J. Immunol.171:4650-4654(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
12.

"The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation."
Salceda S. , Tang T. , Kmet M. , Munteanu A. , Ghosh M. , Macina R. , Liu W. , Pilkington G. , Papkoff J.
Exp. Cell Res.306:128-141(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
13.

"B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma."
Kryczek I. , Zou L. , Rodriguez P. , Zhu G. , Wei S. , Mottram P. , Brumlik M. , Cheng P. , Curiel T. , Myers L. , Lackner A. , Alvarez X. , Ochoa A. , Chen L. , Zou W.
J. Exp. Med.203:871-881(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
14.

"Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells."
Kryczek I. , Wei S. , Zou L. , Zhu G. , Mottram P. , Xu H. , Chen L. , Zou W.
J. Immunol.177:40-44(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
15.

"B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival."
Krambeck A.E. , Thompson R.H. , Dong H. , Lohse C.M. , Park E.S. , Kuntz S.M. , Leibovich B.C. , Blute M.L. , Cheville J.C. , Kwon E.D.
Proc. Natl. Acad. Sci. U.S.A.103:10391-10396(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;USE AS A MARKER FOR RENAL CELL CANCER
16.

"Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma."
Kryczek I. , Wei S. , Zhu G. , Myers L. , Mottram P. , Cheng P. , Chen L. , Coukos G. , Zou W.
Cancer Res.67:8900-8905(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
17.

"B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration."
Miyatake T. , Tringler B. , Liu W. , Liu S.-H. , Papkoff J. , Enomoto T. , Torkko K.C. , Dehn D.L. , Swisher A. , Shroyer K.R.
Gynecol. Oncol.106:119-127(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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